Endotoxin

1. Front Matter

   Pages i-xvii

   PDF

2. Synthesis, Structure and Function

   1. Front Matter

      Pages 1-1

      PDF

   2. Chemical Synthesis of Endotoxin

      • S. Kusumoto, N. Kusunose, M. Imoto, T. Kamikawa, T. Shiba

      Pages 3-11

   3. Structural Requirements of Lipid a for Endotoxicity and Other Biological Activities—An Overview

      • S. Kotani, H. Takada

      Pages 13-43

   4. Natural Variants of Lipid A

      • H. Mayer, J. H. Krauss, A. Yokota, J. Weckesser

      Pages 45-70

   5. Immunochemistry of Lipid A

      • N. Kasai, S. Arata, J. Mashimo, T. Hirayama, M. Ueno

      Pages 71-79

   6. Bacterial Lipopolysaccharides: Relationship of Structure and Conformation to Endotoxic Activity, Serological Specificity and Biological Function

      • E. Th. Rietschel, L. Brade, U. Schade, U. Seydel, U. Zähringer, K. Brandenburg et al.

      Pages 81-99

   7. Structure-Activity Relationship of Chemically Synthesized Nonreducing Parts of Lipid a Analogs

      • J. Y. Homma, M. Matsuura, Y. Kumazawa

      Pages 101-119

   8. The Chemical Structure of the Lipopolysaccharide of a Rc-Type Mutant of Proteus mirabilis Lacking 4-Amino-4-Deoxy-L Arabinose and Its Susceptibility towards Polymyxin B

      • J. Radziejewska-Lebrecht, U. R. Bhat, H. Brade, W. Kaca, H. Mayer

      Pages 121-126

   9. The Structure of O-Specific Polysaccharide of Proteus vulgaris 019 Lipopolysaccharide

      • E. V. Vinogradov, W. Kaca, Y. A. Knirel, A. Rozalski, K. Kotelko, N. K. Kochetkov

      Pages 127-130

   10. Endotoxins of Pseudomonas fluorescens

       • G. M. Zdorovenko, S. N. Veremeychenko, I. Ya. Zakharova, Yu. A. Knirel

       Pages 131-135

   11. Cloning and Expression of rfe Gene

       • M. Ohta, N. Kido, K. Jann, Y. Arakawa, T. Komatsu, H. Ito et al.

       Pages 137-139

   12. Cloning and Analysis of rfb Gene Synthesizing the Mannan O Side Chain of Escherichia coli 09 Lipopolysaccharide

       • N. Kido, M. Ohta, H. Ito, K-I. Iida, Y. Arakawa, T. Komatsu et al.

       Pages 141-145

3. Active Sites, Contaminants, Qualitative and Quantitative Assays

   1. Front Matter

      Pages 147-147

      PDF

   2. The Activation of C3H/HeJ Cells by Certain Types of Lipopolysaccharides

      • B. M. Sultzer, R. Castagna

      Pages 149-157

   3. Lipoamino Acids which are Similar to Bacterial Endotoxin in Both Structure and Biological Activity Related to Physiological Function

      • Y. Kawai, K. Akagawa, I. Yano

      Pages 159-162

   4. Chemistry and Biology of a Novel Lipid Contaminant of Some Endotoxin Preparations with Selective Cytotoxicity to Transformed Cells

      • T. Keler, C. A. D. Smith, A. Nowotny

      Pages 163-184

   5. Porin as a Component of Yersinia Pseudotuberculosis Endotoxin

      • Yu. S. Ovodov, T. F. Solovjeva, V. A. Khomenko, O. D. Novikova, G. M. Frolova, I. M. Yermak et al.

      Pages 185-187

   6. Lipopolysaccharides of Non-Cholera Vibrios Possessing Common Antigen Factor to 01 Vibrio cholerae

      • K. Hisatsune, Y. Haishima, T. Iguchi, S. Kondo

      Pages 189-197

   7. Immunocytochemical Localization of Bacterial Lipopolysaccharide with Colloidal-Gold Probes in Different Target Cells

      • A. M. Municio, S. Abarca, J. L. Carrascosa, R. Garcia, I. Diaz-Laviada, M. J. Ainaga et al.

      Pages 199-202

This volume is based on the proceedings of the International Symposium on Bacterial Endotoxins held in Japan. May 11-14. 1988 and sponsored by the International Endotoxin Society and the International Society for Immuno­ pharmacology. Speakers and participants of this symposium provided new information concerning fundamental and clinical aspects of endotoxin research conducted over the last half decade or so. Advances have been made in understanding the structure and nature of endotoxin molecules and their effects on a wide variety of both cellular and subcellular aspects, of immunity. metabolism and physiology. both in vivo and in vitro. Endotoxins are constituents of gram negative bacteria. Since their original discovery in the nineteenth century. many laboratories studied their chemical composition. their physico- and immunochemica1 properties. as well as their pharmacological and physiological effects on the host. Much is now known about the chemical structure of the endotoxins. There is also a grow­ ing body of information concerning the multiple effects of endotoxins on the host including immune mechanisms. Some effects have been found to be benefi­ cial to the host and endotoxins are being used more frequently to induce important mediators of immunity as well as increasing resistance against infections by many microorganisms as well as inhibiting growth of tumors in experimental animal models and in man.

• bacteria
• immunity
• infection
• infections
• pharmacology
• physiology
• resistance

• The University of South Florida, Tampa, USA

  Herman Friedman, T. W. Klein

• Jichi Medical School, Tochigi-Ken, Japan

  Masayasu Nakano

• University of Pennsylvania, Philadelphia, USA

  Alois Nowotny

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