DNA Damage and Repair

1. Front Matter

   Pages i-xi

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2. Twenty Five Years of DNA Repair

   • R. B. Setlow

   Pages 1-9

3. Macromolecular Physiology of the Escherichia coli UVR Proteins

   • Lawrence Grossman, Euk Y. Oh, Sharlyn Mazur, Paul Caron

   Pages 11-15

4. Toward an Understanding of Nucleotide Excision Repair in Yeast: A Summary of Recent Progress

   • Louie Naumovski, Wolfram Siede, William A. Weiss, Errol C. Friedberg

   Pages 17-25

5. Isolation and Characterization of Genes Involved in Mammalian Excision Repair

   • Jan H. J. Hoeijmakers, M. van Duin, M. Koken, A. Yasui, N. G. J. Jaspers, A. Westerveld et al.

   Pages 27-36

6. Selective DNA Repair in the Transcribed Strands of Active Genes in Mammalian Cells

   • Isabel Mellon, Graciela Spivak, Philip C. Hanawalt

   Pages 37-42

7. Chromosomal Mapping of Human DNA Repair Genes

   • Miria Stefanini

   Pages 43-49

8. Inhibiting DNA Repair — Models, Manipulations and Misconceptions

   • Andrew Collins

   Pages 51-60

9. The Association of Xeroderma Pigmentosum with Trichothiodystrophy: A Clue to a Better Understanding of XP-D?

   • Fiorella Nuzzo, Miria Stefanini

   Pages 61-72

10. In Vitro Correction of Cells from Patients with Mutagen Hypersensitivity

    • N. G. J. Jaspers, L. Roza, W. Vermeulen, A. Eker, R. D. F. M. Taalman, J. H. J. Hoeijmakers et al.

    Pages 73-82

11. DNA Alkylation Adducts in Human Cells Attributable to Exposure to Alkylating Agents

    • R. Montesano, P. Degan, M. Serres, C. P. Wild

    Pages 83-86

12. DNA Repair of Alkylation Damage and Its Relevance to Mutation Fixation in Mammalian Cells

    • M. Bignami, G. Aquilina, A. Zijno, G. Frosina, A. Abbondandolo, E. Dogliotti

    Pages 87-95

13. Mechanisms of Alkylating Agent Induced Cytotoxicity in E.coli and Mammalian Cells

    • J. Hall, P. Karran, H. Kataoka, P. Macpherson, C. Stephenson

    Pages 97-106

14. The Response of Human Cells to In Vivo Methylation Damage

    • B. Strauss, D. Sagher, T. Karrison, R. Larson, P. Meier, J. Schwartz et al.

    Pages 107-123

15. Repair of Secondary Lesions Arising in DNA after Treatment with Alkylating Agents

    • Jacques Laval, Timothy R. O’Connor, Serge Boiteux

    Pages 125-133

16. Inducible Repair of Alkylated Bases in Mammalian Cells

    • Patricia Lefebvre, Françoise Laval

    Pages 135-141

17. DNA Strand Bias During O6-Methylguanine Mutagenesis

    • John M. Essigmann

    Pages 143-150

18. Formation and Enzymatic Repair of Specific Reaction Products of Alkylating N-Nitroso Carcinogens in Cellular DNA: Relevance to Malignant Transformation

    • Manfred F. Rajewsky, Juergen Thomale, Nam-ho Huh, Peter Nehls, Gertrud Eberle

    Pages 151-156

19. DNA Damage and Repair in Human Skin In Situ

    • Betsy M. Sutherland, Richard W. Gange, Steven E. Freeman, John C. Sutherland

    Pages 157-168

20. DNA Repair and Mutagenesis Induced by Dimer and Non-Dimer Photoproducts Measured with Plasmid Vectors in Xeroderma Pigmentosum Cells

    • Kenneth H. Kraemer, Saraswathy Seetharam, Miroslava Protic-Sabljic, Anders Bredberg, Douglas E. Brash, Michael M. Seidman

    Pages 169-181

The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com­ mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino­ genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna­ tional meetings and although the meetings often have sessions devoted to DNA repair, they do not bring together a wide diversity of international workers in the field to exchange ideas. The purpose of the Congress was to facilitate such an exchange among scientists representing many fields of endeavor and many countries. The 37 manuscripts in this volume, presented by the invited spea­ kers during the four and half days of the Congress, encompass the field of DNA damage and repair. They cover biological systems ranging from mo­ lecules to humans and deal with damages and repair after treatment of cells with various types of radiations, chemicals, and exogenous and en­ dogenous oxidative damages. The Congress and its Proceedings are dedicated to two international leaders in the field of DNA damage and repair, Alexander Hollaender of the United States and Adriano Buzzati Traverso of Italy. Hollaender, who died in December 1986, was one of the first investigators to recognize the damage to DNA was important in cell killing and mutagenesis. His early work indicated that cells could recover from radiation injury.

• DNA
• DNA repair
• Nucleotide
• biological
• biology
• cell
• cells
• energy
• methylation
• molecular biology
• mutation
• oncogene
• protein
• radiation
• synthesis

• Department of Environment and Health Protection, ENEA, Rome, Italy

  Amleto Castellani

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