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The Postmortem Brain in Psychiatric Research

  • Book
  • © 2002

Overview

Editors:
  1. Galila Agam

    1. Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

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  2. Ian Paul Everall

    1. Departments of Neuropathology and Psychological Medicine, Institute of Psychiatry, London, UK

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  3. R. H. Belmaker

    1. Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

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Part of the book series: Neurobiological Foundation of Aberrant Behaviors (NFAB, volume 4)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    1. Introduction

      • E. Fuller Torrey, Michael B. Knable
      Pages 1-2

  3. Methodology and General Findings

    1. Psychiatric Brain Banks: Situation in Europe and Asia

      • I. Matsumoto, S. I. Niwa, R. Ravid
      Pages 3-19

    2. Methodological and Stereological Considerations in Postmortem Psychiatric Brain Research

      • Ian Paul Everall, Paul J. Harrison
      Pages 21-35

    3. Imaging VS Postmortem Receptor Studies: What You See is What You Get?

      • Lyn Pilowsky
      Pages 37-48

    4. Glial Pathology in Major Psychiatric Disorders

      • David R. Cotter, Carmine M. Pariante, Grazyna Rajkowska
      Pages 49-73

    5. Indications of Abnormal Connectivity in Neuropsychiatric Disorders in Postmortem Studies

      • William G. Honer
      Pages 75-91

    6. Studies in the Human Frontal Cortex: Evidence for Changes in Neurochemical Markers in Schizophrenia and Bipolar Disorder

      • Brian Dean
      Pages 93-103

    7. Summary of Prefrontal Molecular Abnormalities in the Stanley Foundation Neuropathology Consortium

      • Michael B. Knable, Beata M. Barci, Maree J. Webster, E. Fuller Torrey
      Pages 105-137

  4. Schizophrenia

    1. Macroanatomical Findings in Postmortem Brain Tissue from Schizophrenic Patients

      • Peter Falkai
      Pages 139-150

    2. Microanatomical Findings in Postmortem Brain Tissue from Subjects with Schizophrenia: Disturbances in Thalamocortical and Corticocortical Connectivity in Schizophrenia

      • T. Hashimoto, D. A. Lewis
      Pages 151-171

    3. In Situ/Histological Approaches to Neurotransmitter-Specific Postmortem Brain Studies of Schizophrenia

      • Susan E. Bachus, Joel E. Kleinman
      Pages 173-210

    4. Defining the Role of Specific Limbic Circuitry in the Pathophysiology of Schizophrenia and Bipolar Disorder

      • Francine M. Benes, Sabina Berretta
      Pages 211-233

    5. Dorsolateral Prefrontal Cortical Parallel Circuit in Schizophrenia: Postmortem Abnormalities

      • Blynn G. Bunney, William E. Bunney, Richard Stein, Steven G. Potkin
      Pages 235-251

    6. Post Mortem Studies of the Hippocampal Formation in Schizophrenia

      • Andrew J. Dwork
      Pages 253-266

    7. GSK-3 and Wnt Markers of Neurodevelopmental Abnormalities in Schizophrenia

      • Nitsan Kozlovsky, Rh Belmaker, Galila Agam
      Pages 267-276
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Keywords

About this book

Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders.
This is the first book to summarize this research approach and the meaningful data which has recently been acquired.

Editors and Affiliations

  • Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

    Galila Agam, R. H. Belmaker

  • Departments of Neuropathology and Psychological Medicine, Institute of Psychiatry, London, UK

    Ian Paul Everall

Bibliographic Information

  • Book Title: The Postmortem Brain in Psychiatric Research

  • Editors: Galila Agam, Ian Paul Everall, R. H. Belmaker

  • Series Title: Neurobiological Foundation of Aberrant Behaviors

  • DOI: https://doi.org/10.1007/978-1-4757-3631-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-7923-7554-8Published: 30 November 2001

  • Softcover ISBN: 978-1-4419-4921-9Published: 07 December 2010

  • eBook ISBN: 978-1-4757-3631-1Published: 09 March 2013

  • Series ISSN: 1568-2625

  • Edition Number: 1

  • Number of Pages: IX, 404

  • Number of Illustrations: 22 b/w illustrations, 1 illustrations in colour

  • Topics: Psychology, general, Neuropsychology, Health Psychology, Neurosciences

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