Molecular Biology of B-Cell and T-Cell Development

1. Front Matter

   Pages i-xiv

   PDF

2. Stem Cells and Lineage Commitment Models

   1. Front Matter

      Pages 1-1

      PDF

   2. Developmental Origins of Hematopoietic Stem Cells

      • Elaine Dzierzak, Alexander Medvinsky

      Pages 3-25

   3. Self-Renewal of Stem Cells

      • Peter M. Lansdorp

      Pages 27-40

   4. Transcription Factors Regulating Early Hematopoietic Development and Lineage Commitment

      • Stuart H. Orkin

      Pages 41-54

3. Intrinsic Factors Regulating B and T Lymphopoiesis

   1. Front Matter

      Pages 55-55

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   2. The Ikaros Gene Family in Hemopoietic Differentiation

      • Nicole Avitahl, Aliki Nichogiannopoulou, Katia Georgopoulos, Susan Winandy

      Pages 57-70

   3. Transcriptional Control of B-Cell Differentiation by EBF and E2A

      • Mikael Sigvardsson, Rudolf Grosschedl

      Pages 71-82

   4. Role of the Transcription Factor BSAP (Pax-5) in B-Cell Development

      • Meinrad Busslinger, Stephen L. Nutt

      Pages 83-110

   5. The Role of PU.1 in the Regulation of Lymphoid and Myeloid Hematopoietic Progenitors

      • Edward W. Scott

      Pages 111-126

   6. Chromatin Structure and Lineage Determination

      • Dimitris Kioussis, Richard Festenstein

      Pages 127-146

4. Extrinsic Factors Regulating B and T Lymphopoiesis

   1. Front Matter

      Pages 147-147

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   2. The Role of Cytokines in Hematolymphoid Development

      • Tannishtha Reya, Simon R. Carding

      Pages 149-175

   3. Life/Death Decisions in B Lymphocyte Precursors

      • Paul W. Kincade, Kay Medina, Glennda Smithson, Zhong Zheng, Kenji Oritani, Lisa Borghesi et al.

      Pages 177-196

   4. Regulation of Lymphocyte Development by Microenvironmental and Systemic Factors

      • Encarnacion Montecino-Rodriguez, Kenneth Dorshkind

      Pages 197-211

   5. Cytokines and Chemokines in T-Cell Development

      • Albert Zlotnik, Myriam Capone, Alain P. Vicari

      Pages 213-229

   6. Cytokine and Stromal Influences on Early B-Cell Development

      • Lisa J. Jarvis, Tucker W. LeBien

      Pages 231-251

5. Commitment and Ordered Progression in Development of Lymphoid Lineages

   1. Front Matter

      Pages 253-253

      PDF

   2. Staging B-Cell Development and the Role of Ig Gene Rearrangement in B Lineage Progression

      • Richard R. Hardy, Susan Shinton, Robert Wasserman, Yue-Sheng Li

      Pages 255-266

   3. Lineage Relationships Between B Lymphocytes and Macrophages

      • Barbara L. Kee, Christopher J. Paige

      Pages 267-283

Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.

• Chemokine
• Immune System
• Ligation
• Macrophages
• Termination
• Transplantation
• gene therapy
• genes
• influence
• molecular biology
• molecular mechanisms
• regulation

". . . can be unequivocally recommended to people involved in the study of lymphocytes and lymphoma research."-Annals of Oncology

"...This volume presents an integrated and comprehensive account of cutting edge advances in understanding B and T lymphocyte development, and a deeper understanding of the actual cellular and molecular processes that control cell fates....this important new book will help spark the growth of new research initiatives at the intersection of these two fields, claiming center ground as essential reading in the field."-Anticancer Research

• University of Pennsylvania, Philadelphia, USA

  John G. Monroe

• California Institute of Technology, Pasadena, USA

  Ellen V. Rothenberg

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