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Allergy and Allergic Diseases

The New Mechanisms and Therapeutics

  • Book
  • © 1998

Overview

Editors:
  1. Judah A. Denburg

    1. Department of Medicine, McMaster University, Hamilton, Canada

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Epidemiology/IgE

    1. Front Matter

      Pages 1-1
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    2. Molecular Mechanisms of Isotype Switching to IgE

      • Donata Vercelli
      Pages 3-11

    3. Cytokines and IgE Regulation

      • Juha Punnonen, Jan E. de Vries
      Pages 13-40

    4. Environmental Allergens

      • Thomas A. E. Platts-Mills, Judith A. Woodfolk, Lisa M. Wheatley
      Pages 41-60

    5. Ontogeny of Allergy

      • Bengt Björkstén
      Pages 61-82

  3. Inflammation: Cellular Aspects

    1. Front Matter

      Pages 83-83
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    2. The Role of Mast Cells in Inflammation and Homeostasis

      • Angus J. MacDonald, Fiona L. Wills, Tong-Jun Lin, A. Dean Befus
      Pages 103-125

    3. Human Langerhans Cells

      • Thomas Bieber
      Pages 127-137

    4. Role of Basophils in Allergic Reactions

      • Peter Valent
      Pages 167-174

    5. Inflammation

      • Sergio Romagnani
      Pages 195-210

    6. T-Cells in the Pathogenesis of Asthma and Allergic Diseases

      • Marc Humbert, Stephen R. Durham
      Pages 211-227

  4. Inflammation: Cellular Aspects

    1. The Role of the Bone Marrow in Allergic Disease

      • Mark D. Inman, Roma Sehmi, Paul M. O’Byrne, Judah A. Denburg
      Pages 85-102

    2. Eosinophils

      • Redwan Moqbel, Paige Lacy
      Pages 139-165

    3. Neurogenic Inflammation in Allergic Disease

      • Peter J. Barnes
      Pages 175-194

    4. Role of CD8+ T-Cells in the Regulation of Immunoglobulin E

      • Paul A. MacAry, David M. Kemeny
      Pages 229-241

    5. Airway Wall Structure

      • Peter K. Jeffery, Mariusz J. Gizycki, Andrew V. Rogers
      Pages 243-280

    6. Epithelium

      • Mary H. Perdue, Derek M. McKay
      Pages 281-303

  5. Inflammation: Molecular Aspects

    1. Front Matter

      Pages 305-305
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  6. Inflammation: Molecular Aspects

    1. Proinflammatory Cytokines in Allergic Disease

      • Daniel L. Hamilos
      Pages 307-329
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Keywords

About this book

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn­ thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in­ flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.

Reviews

"The book presents a broad overview of the field at a level that is easy to understand. . .provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming"-Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine

"...an excellent book on allergy and allergic diseases....a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new "jungle hypothesis" of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment." - Allergy

"The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery." - EACCI

Editors and Affiliations

  • Department of Medicine, McMaster University, Hamilton, Canada

    Judah A. Denburg

Bibliographic Information

  • Book Title: Allergy and Allergic Diseases

  • Book Subtitle: The New Mechanisms and Therapeutics

  • Editors: Judah A. Denburg

  • DOI: https://doi.org/10.1007/978-1-4757-2776-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1998

  • Hardcover ISBN: 978-0-89603-404-4Published: 04 August 1998

  • Softcover ISBN: 978-1-61737-026-7Published: 05 November 2010

  • eBook ISBN: 978-1-4757-2776-0Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XVI, 599

  • Topics: Allergology

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