Dietary Fat and Cancer

1. Front Matter

   Pages i-xvi

   PDF

2. Fat and Cancer

   • Laurence N. Kolonel

   Pages 1-19

3. Dietary Lipids and the Cancer Cascade

   • Steven K. Clinton

   Pages 21-37

4. Molecular Studies on the Role of Dietary Fat and Cholesterol in Breast Cancer Induction

   • Michael C. Archer, Ahmed El-Sohemy, Laurie L. Stephen, Alaa F. Badawi

   Pages 39-46

5. Fatty Acid Regulation of Breast Cancer Cell Growth and Invasion

   • David P. Rose, Jeanne M. Connolly, Xin-Hua Liu

   Pages 47-55

6. Fatty Acids and Breast Cancer Cell Proliferation

   • Robert W. Hardy, Nalinie S. M. D. Wickramasinghe, S. C. Ke, Alan Wells

   Pages 57-69

7. Lipoxygenase Metabolites and Cancer Metastasis

   • Keqin Tang, Kenneth V. Honn

   Pages 71-84

8. Modulation of Intracellular Second Messengers by Dietary Fat during Colonic Tumor Development

   • Robert S. Chapkin, Yi-Hai Jiang, Laurie A. Davidson, Joanne R. Lupton

   Pages 85-96

9. Diet, Apoptosis, and Carcinogenesis

   • Craig D. Albright, Rong Liu, Mai-Heng Mar, Ok-Ho Shin, Angelica S. Vrablic, Rudolf I. Salganik et al.

   Pages 97-107

10. The Role of Peroxisome Proliferator Activated Receptor α in Peroxisome Proliferation, Physiological Homeostasis, and Chemical Carcinogenesis

    • Feank J. Gonzalez

    Pages 109-125

11. A Hypothetical Mechanism for Fat-Induced Rodent Hepatocarcinogenesis

    • Daniel J. Noonan, Michelle L. O’Brien

    Pages 127-135

12. Short Chain Fatty Acid Regulation of Intestinal Gene Expression

    • John A. Barnard, J. A. Delzell, N. M. Bulus

    Pages 137-144

13. Regulation of Gene Expression in Adipose Cells by Polyunsaturated Fatty Acids

    • David A. Bernlohr, Natalie Ribarik Coe, Melanie A. Simpson, Ann Vogel Hertzel

    Pages 145-156

14. Regulation of Peroxisomal Fatty Acyl-CoA Oxidase in the Yeast

    • Gillian M. Small, Igor V. Karpichev, Yi Luo

    Pages 157-166

15. Dietary Fat, Genes, and Human Health

    • Donald B. Jump, Steven D. Clarke, Annette Thelen, Marya Liimatta, Bing Ren, Maria V. Badin

    Pages 167-176

16. Session V

    • Diane F. Birt

    Pages 177-179

17. Abstracts

    • American Institute for Cancer Research

    Pages 181-243

18. Back Matter

    Pages 245-252

    PDF

The annual research conference for 1996 of the American Institute for Cancer Re­ search was again held at the Loews L'Enfant Plaza Hotel in Washington, DC, August 29 and 30. The topic for this, the seventh in the series, was "Dietary Fat and Cancer: Genetic and Molecular Mechanisms. " Two separate presentations were given as the conference overview. "Fat and Cancer: The Epidemiologic Evidence in Perspective" noted that die­ tary fat can be saturated, largely from animal or dairy sources, or mono- or polyunsatu­ rated, mostly from plant sources. Unlike animal fats, fish contain relatively high levels of protective omega-3 fatty acids. Although the hypothesis that dietary fat is associated with cancer is plausible, the mechanisms involved are reasonable, and many animal studies support the hypothesis, there are many obstacles in any direct extrapolation to humans, in­ cluding imprecise measures of dietary fat intake, variability in individual diets, and spe­ cies variations. Despite these limitations, there is a weak positive correlation between colon cancer and dietary fat intake, but with substantial differences for various ethnic groups. In the case of breast cancer, there is substantial variation among countries and eth­ nic groups, but the overall evidence indicated an association with fat in the diet. Epidemiologic studies of dietary fat and prostate cancer are more consistent and most show a positive relationship. However, it was not clear which types of dietary fat were im­ plicated in the effect.

• Colon
• Metabolite
• apoptosis
• cancer
• gene expression
• genes
• molecular mechanisms

• USA

  American Institute for Cancer Research

Policies and ethics