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Molecular Diagnostics

For the Clinical Laboratorian

  • Book
  • © 1997

Overview

Editors:
  1. William B. Coleman

    1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Gregory J. Tsongalis

    1. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Pathology and Laboratory Medicine (PLM)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
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  2. Basic Molecular Biology

    1. Front Matter

      Pages 1-1
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    2. A Historical Perspective on the Clinical Diagnostic Laboratory

      • Robert E. Moore
      Pages 3-13

    3. An Overview of Nucleic Acid Chemistry, Structure, and Function

      • William B. Coleman
      Pages 15-33

    4. Basic Nucleic Acid Procedures

      • R. Keith Esch
      Pages 35-60

  3. Molecular Technologies

    1. Front Matter

      Pages 61-61
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    2. Nucleic Acid Blotting Techniques

      • Sharon Collins Presnell
      Pages 63-87

    3. DNA Amplification Techniques

      • David H. Sorscher
      Pages 89-101

    4. RT-PCR

      • Robert B. Sisk
      Pages 103-121

    5. PCR-Based Methods for Mutation Detection

      • Elizabeth M. Rohlfs, W. Edward Highsmith Jr.
      Pages 123-162

    6. Nucleic Acid Hybridization and Amplification In Situ

      • Matthew S. Cowlen
      Pages 163-191

    7. Gene Therapy

      • Jeffrey S. Bartlett
      Pages 193-214

  4. Applications to Molecular Pathology

    1. Front Matter

      Pages 215-215
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    2. An Overview of Molecular Genetics

      • Gregory J. Tsongalis
      Pages 217-228

    3. Genetic Basis of Neurologic and Neuromuscular Diseases

      • Myra J. Wick, Pamela A. Crifasi, Zhenyuan Wang, Stephen N. Thibodeau
      Pages 229-248

    4. Molecular Mechanisms of Endocrine Disorders

      • Bruce F. Bower, Carl D. Malchoff
      Pages 249-269

    5. Molecular Pathogenesis of Cardiovascular Disease

      • John H. Contois, Juch Chin Huang
      Pages 271-291

    6. Molecular Mutations in Human Neoplastic Disease

      • William B. Coleman, Gregory J. Tsongalis
      Pages 293-316

    7. Molecular Genetics and the Diagnosis of Hematological Malignancies

      • William N. Rezuke, Evelyn C. Abernathy
      Pages 317-339

    8. Molecular Techniques in Laboratory Diagnosis of Infectious Diseases

      • Jaber Aslanzadeh
      Pages 341-360
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Keywords

About this book

Notable practitioners describe how laboratory medicine is practiced today and illuminate how it will function tomorrow as the revolutionary advances afforded by molecular diagnostics become increasingly central to effective analysis. Proceeding from a discussion of elementary nucleic acid technology to a review of the more advanced techniques, the distinguished contributors lay the groundwork for a comprehensive understanding of their applications throughout clinical medicine. The result is a detailed description of those molecular technologies currently used in diagnostic laboratories, as well as those that seem particularly promising. Detailed discussions of specific clinical applications include those for cancer, hematological malignancies, cardiovascular disease, and neuromuscular, endocrine, and infectious diseases.

Reviews

". . .highly recommended. . .for those interested in clinical molecular diagnosis."-American Journal of Clinical Pathology
". . .a very good introduction to the basic elements of molecular pathology. . .a clear, enjoyable read. . .an excellent discussion of methods."-Clinical Chemistry

Editors and Affiliations

  • Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA

    William B. Coleman

  • Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA

    Gregory J. Tsongalis

Bibliographic Information

  • Book Title: Molecular Diagnostics

  • Book Subtitle: For the Clinical Laboratorian

  • Editors: William B. Coleman, Gregory J. Tsongalis

  • Series Title: Pathology and Laboratory Medicine

  • DOI: https://doi.org/10.1007/978-1-4757-2588-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1997

  • eBook ISBN: 978-1-4757-2588-9Published: 18 April 2013

  • Edition Number: 1

  • Number of Pages: X, 390

  • Number of Illustrations: 62 b/w illustrations

  • Topics: Pathology

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