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Biology of Growth Factors

Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications

  • Book
  • © 1988

Overview

Editors:
  1. Jeffrey E. Kudlow

    1. Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Canada

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  2. David H. MacLennan

    1. Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

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  3. Alan Bernstein

    1. Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Canada

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  4. Avrum I. Gotlieb

    1. Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Canada

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 234)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
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  2. Perspectives on the Control of Growth and Differentiation

    1. Perspectives on the Biology of Growth Factors

      • Irving B. Fritz
      Pages 1-8

    2. Platelet-Derived Growth Factor — Its Role in Health and Disease

      • Russell Ross, Elaine W. Raines
      Pages 9-21

    3. Molecular and Developmental Biology Aspects of Fibroblast Growth Factor

      • Denis Gospodarowicz
      Pages 23-39

    4. Chemical and Biochemical Properties of Human Angiogenin

      • Bert L. Vallee, James F. Riordan
      Pages 41-53

  3. Growth Factor — Oncogene Relationships

    1. Structure-Function Relationships in Cellular and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases

      • Tony Pawson, Peter Greer, Michael Moran, Kelly Meckling-Hansen, Angela Brooks-Wilson, Ivan Sadowski
      Pages 55-64

    2. Regulation of Cell Growth and Transformation by the Epidermal Growth Factor Receptor

      • Joseph Schlessinger
      Pages 65-73

    3. Colony Stimulating Factor-1 Stimulated Macrophage Membrane Protein Phosphorylation

      • Paul T. Jubinsky, Yee-Guide Yeung, Rosalba Sacca, Wei Li, E. Richard Stanley
      Pages 75-90

  4. Receptor Transducing Mechanisms

    1. Analysis of Functional Domains in the Epidermal Growth Factor Receptor Using Site-Directed Mutagenesis

      • Gordon N. Gill, Michael G. Rosenfeld, William S. Chen, Paul J. Bertics, Cheri S. Lazar
      Pages 91-103

    2. Regulation of EGF Receptor and Transforming Growth Factor-Alpha Expression

      • Jeffrey E. Kudlow, Jeffrey D. Bjorge, Michael S. Kobrin, Andrew J. Paterson
      Pages 105-126

    3. Structural and Functional Studies of Protein Kinase C

      • Gerard M. Housey, Mark D. Johnson, W. L. Wendy Hsiao, Catherine A. O’Brian, I. Bernard Weinstein
      Pages 127-140

    4. The ras Pathway: A Model for the Control of Proliferation in Animal Cells

      • Dennis W. Stacey
      Pages 141-167

    5. The Ca2+/Phospholipid-Binding Proteins of the Submembraneous Skeleton

      • Tony Hunter
      Pages 169-193

    6. Function of the Antigen Receptor in T Cell Activation

      • Mark A. Goldsmith, Arthur Weiss
      Pages 195-211

    7. The Endosomal Apparatus and Transmembrane Signalling

      • J. J. M. Bergeron, W. H. Lai, D. G. Kay, J. J. Doherty II, M. N. Khan, B. I. Posner
      Pages 213-224

    8. Cytosolic Substrates for the Insulin Receptor Kinase

      • Yan C. Kwok, Cecil C. Yip
      Pages 225-233

  5. Back Matter

    Pages 235-238
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Keywords

About this book

Growth factors are elaborated to control the growth of cells in such physiological processes as wound healing, tissue regeneration and the immune response. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled proliferative signals to neoplasia, on the possible involvement of growth factors in the development of blood vessel diseases as seen in diabetes and atherosclerosis, on the altered immune surveillance that leads to autoimmunity and on the fundamental mechanisms by which growth factors signal their target cells. We expect that the contents of this volume will help promote understanding of the role of these fundamental biological processes and their alterations in a wide variety of disease states and stimulate new investi­ gations in this important area of biomedical research. The Editors v CONTENTS PERSPECTIVES ON THE CONTROL OF GROWTH AND DIFFERENTIATION Perspectives on the Biology of Growth Factors . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived Growth Factor- Its Role in Health and Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 R. Ross and E. W. Raines Molecular and Developmental Biology Aspects of Fibroblast Growth Factor. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical Properties of Human Angiogenin. . . . . . . . . . 41 B. L. Vallee and J. F. Riordan GROWTH FACTOR - ONCOGENE RELATIONSHIPS Structure - Function Relationships in Cellular andViral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . 55 T. Pawson. P. Greer, M. Moran, K.

Editors and Affiliations

  • Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes Centre, University of Toronto General Hospital, Toronto, Canada

    Jeffrey E. Kudlow

  • Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

    David H. MacLennan

  • Department of Medical Genetics and Medical Biophysics, University of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research Institute, Toronto, Canada

    Alan Bernstein

  • Department of Pathology and Banting and Best Diabetes Centre, University of Toronto and Toronto General Hospital General Hospital, Toronto, Canada

    Avrum I. Gotlieb

Bibliographic Information

  • Book Title: Biology of Growth Factors

  • Book Subtitle: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications

  • Editors: Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4757-1980-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1988

  • Softcover ISBN: 978-1-4757-1982-6Published: 26 March 2013

  • eBook ISBN: 978-1-4757-1980-2Published: 09 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 238

  • Number of Illustrations: 56 b/w illustrations

  • Topics: Biochemistry, general

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