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Regression of Atherosclerotic Lesions

Experimental Studies and Observations in Humans

  • Book
  • © 1984

Overview

Editors:
  1. M. Rene Malinow

    1. Oregon Regional Primate Research Center, Beaverton, USA

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  2. Victor H. Blaton

    1. Department of Clinical Chemistry, A. Z. St. Jan Hospital, Brugge, Belgium

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introduction: NATO Advanced Study Institute on Regression of Atherosclerotic Lesions

    1. Introduction: NATO Advanced Study Institute on Regression of Atherosclerotic Lesions

      • M. R. Malinow
      Pages 1-4

  3. Regression of Atherosclerosis in Animals

    1. The Pathobiology of the Atherosclerotic Plaque in the Mid-1980s

      • Robert W. Wissler
      Pages 5-20

    2. Interaction of Therapeutic Diets and Cholesterol-Lowering Drugs in Regression Studies in Animals

      • Robert W. Wissler, Dragoslava Vesselinovitch
      Pages 21-41

    3. Progression and Regression of Nonhuman Primate Coronary Artery Atherosclerosis: Considerations of Experimental Design

      • Thomas B. Clarkson
      Pages 43-60

    4. The Comparative Pathology of Nonhuman Primate Atherosclerosis

      • Thomas B. Clarkson, Mary S. Anthony, Robert W. Prichard
      Pages 61-78

    5. Plant Glycosides: Effects on Atherosclerosis Regression in Macaca Fascicularis

      • M. R. Malinow
      Pages 79-103

    6. Plasma Lipoprotein Changes Induced by Diets. Effect on Progression and Regression of Arterial Lesions in Nonhuman Primates

      • Victor H. Blaton, B. Declerq
      Pages 105-120

    7. Regression of Arterial Lesions in Animal Models: Scanning and Transmission Electron Microscopic Aspects

      • Giorgio Weber, Piera Fabbrini, Loretta Resi, Piero Tanganelli
      Pages 121-129

    8. Use of Cholesteryl Ester Analogs to Study Transport of Lipoproteins in Intact Animals

      • Yechezkiel Stein, Yoseph Kleinman, Gideon Halperin, Olga Stein
      Pages 131-144

    9. Interaction between Lipids and the Intercellular Matrix of the Arterial Wall: Its Role in the Evolution of the Atherosclerotic Lesions

      • Ladislas Robert, Jean Chaudiere, Bernard Jacotot
      Pages 145-173

  4. Studies on Human Atherosclerosis

    1. Evolution of Human Atherosclerotic Lesions

      • K. W. Walton
      Pages 175-185

    2. Possible Recognition of Atherosclerosis Regression in Humans

      • K. W. Walton
      Pages 187-200

    3. High-Density Lipoproteins and Their Role in Preventing or Retarding Atherosclerosis

      • Gerd Assmann, Hilko Schriewer
      Pages 201-216

    4. Studies on Arterial Interstitial Fluid

      • Elspeth B. Smith
      Pages 217-233

    5. Comparison of the Morphology of Atherosclerotic Lesions in the Coronary Arteries of Man with Morphology of Lesions Produced and Regressed in Experimental Primates

      • H. C. Stary
      Pages 235-254

    6. Control or Reversal of Atherosclerosis Through Therapy of Lipid Disorders

      • Richard J. Havel, John P. Kane, Mary J. Malloy
      Pages 255-261

    7. Planning and Evaluation of Studies on Atherosclerosis in Controlled Clinical Trials

      • Stanley Azen, David H. Blankenhorn, Sharon Nessim
      Pages 263-275

    8. Status of Controlled Clinical Trials in Peripheral Vessel Atherosclerosis

      • Stanley Azen, David H. Blankenhorn, Sharon Nessim
      Pages 277-288

    9. Regression of Atherosclerosis in Man: Current Data and Their Methodological Limitations

      • B. Greg Brown, Edward L. Bolson, Cynthia D. Pierce, Robert B. Peterson, Harold T. Dodge
      Pages 289-310
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Keywords

About this book

The Advanced Study Institute on Regression of Atherosclerotic Lesions, sponsored by the North Atlantic Treaty Organization, was held in Maratea, Italy, September 11-13, 1983. The institute was designed to foster discussion of experimental data on the regression of atherosclerosis in animals and evidence of a similar phenomenon in humans. The participating scientists showed with anatomical and biochemical data, that atherosclerosis regresses in cholesterol fed animals after withdrawal of atherogenic stimuli. The existence of regression in humans was inferred from sequential angiographic visualization of arteries, but anatomical and biochemical characteristics of the process have not been defined. Two mechanisms are probably involved in such an angiographic regression. The first, which may occur when hyperlipidemia is partly or fully corrected or during undernutrition or other metabolic abnormalities, may be related to atherosclerosis changes noted in animals undergoing regression. The second type seems independent of changes in plasma lipid levels and may involve resolution of thrombi or other underlying arterial wall factors. The relative frequencies of the two mechanisms are unknown; whether they can occur simultaneously also warrants consideration. It is likely that an exciting milestone will be forthcoming when regression of atherosclerosis is unequivocally demonstrated in humans. Publication of these institute proceedings constitutes a valuable background for future developments.

Editors and Affiliations

  • Oregon Regional Primate Research Center, Beaverton, USA

    M. Rene Malinow

  • Department of Clinical Chemistry, A. Z. St. Jan Hospital, Brugge, Belgium

    Victor H. Blaton

Bibliographic Information

  • Book Title: Regression of Atherosclerotic Lesions

  • Book Subtitle: Experimental Studies and Observations in Humans

  • Editors: M. Rene Malinow, Victor H. Blaton

  • DOI: https://doi.org/10.1007/978-1-4757-1773-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1984

  • Softcover ISBN: 978-1-4757-1775-4Published: 15 April 2013

  • eBook ISBN: 978-1-4757-1773-0Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: IX, 355

  • Number of Illustrations: 37 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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