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Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

  • Book
  • © 1993

Overview

Editors:
  1. Avraham Yacobi

    1. Pharmacodynamics Research, American Cyanamid Company, Medical Research, Pearl River, USA

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  2. Jerome P. Skelly

    1. Office of Research Resources, Center for Drug Evaluation and Research, Food and Drug Administration, USA

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  3. Vinod P. Shah

    1. Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, USA

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  4. Leslie Z. Benet

    1. Department of Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  4. Methodology for Preclinical Pharmacodynamic Studies

    1. Preclinical Pharmacodynamics of Central Nervous System Active Agents

      • M. Danhof, J. W. Mandema, A. Hoogerkamp
      Pages 69-80

    2. Preclinical Pharmacodynamics of Antihypertensives

      • Robert A. Branch, Edwin K. Jackson
      Pages 81-89

    3. Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administration

      • Lawrence G. Miller
      Pages 91-96

    4. Guidelines for Development of a New Diuretic Agent

      • D. Craig Brater
      Pages 97-103

    5. Preclinical Pharmacodynamics of Anti-Inflammatory Drugs

      • Asoke Mukherjee, Conrad Chen, Lucy Jean, Claude B. Coutinho
      Pages 105-113

  5. Preclinical & Clinical Pharmacokinetics

    1. The Role of Pharmacokinetics in the Drug Development Process

      • Leslie Z. Benet
      Pages 115-123

    2. Implementation of an Effective Pharmacokinetics Research Program in Industry

      • Avraham Yacobi, Vijay K. Batra, Robert E. Desjardins, Robert D. Faulkner, Gabriela Nicolau, William R. Pool et al.
      Pages 125-135

    3. Pharmacoepidemiology, Population Pharmacokinetics and New Drug Development

      • Thaddeus H. Grasela Jr., Edward J. Antal
      Pages 137-148

    4. Assessment of Pharmacokinetic Drug Interactions in Clinical Drug Development

      • Jerome J. Schentag
      Pages 149-157

  6. Clinical Pharmacodynamics

    1. Pharmacokinetic/Pharmacodynamic Models and Methods

      • Davide Verotta, Lewis B. Sheiner
      Pages 159-177

    2. Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs

      • Donald R. Stanski
      Pages 179-192
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Keywords

Editors and Affiliations

  • Pharmacodynamics Research, American Cyanamid Company, Medical Research, Pearl River, USA

    Avraham Yacobi

  • Office of Research Resources, Center for Drug Evaluation and Research, Food and Drug Administration, USA

    Jerome P. Skelly

  • Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, USA

    Vinod P. Shah

  • Department of Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, USA

    Leslie Z. Benet

Bibliographic Information

  • Book Title: Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

  • Editors: Avraham Yacobi, Jerome P. Skelly, Vinod P. Shah, Leslie Z. Benet

  • DOI: https://doi.org/10.1007/978-1-4757-1520-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Softcover ISBN: 978-1-4757-1522-4Published: 30 May 2013

  • eBook ISBN: 978-1-4757-1520-0Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XVI, 270

  • Number of Illustrations: 5 b/w illustrations

  • Topics: Pharmacology/Toxicology, Pharmacy

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