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Purine Metabolism in Man

Biochemistry and Pharmacology of Uric Acid Metabolism

  • Book
  • © 1974

Overview

Editors:
  1. Oded Sperling

    1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

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  2. Andre Vries

    1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

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    You can also search for this editor in PubMed   Google Scholar

  3. James B. Wyngaarden

    1. Department of Medicine, Duke University Medical Center, Durham, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 41)

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Table of contents (62 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Gout

    1. Front Matter

      Pages xxiii-xxiii
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    2. Etiology of Purine Overproduction in Gout

      1. The Kinetics of Intramolecular Distribution of 15N in Uric Acid Following Administration of 15N-Glycine: Preferential Labeling of N−(3+9) of Uric Acid in Primary Gout and a Reappraisal of the “Glutamine Hypothesis”
        • Oded Sperling, James B. Wyngaarden, C. Frank Starmer
        Pages 371-393
      2. Hyperglutamatemia in Primary Gout
        • Alexander B. Gutman, Ts’ai-Fan Yü
        Pages 395-399
      3. Reduced Renal Ammoniagenesis in Primary Gout
        • Alexander B. Gutman, Ts’ai-Fan Yü
        Pages 401-405
      4. The Uptake of Glycine-14C into the Adenine and Guanine of DNA and Insoluble RNA of Human Leucocytes
        • G.-N. Chang, A. Fam, A. H. Little, A. Malkin
        Pages 407-416

    3. Effects of Diet, Weight, and Stress on Purine Metabolism

      1. In Certain Physiological Stress Conditions on the Problem of Hyperuricemia
        • I. Machtey, A. Meer
        Pages 419-421
      2. Uric Acid Metabolism Following Acute Myocardial Infarction
        • J. A. Dosman, J. C. Crawhall, G. A. Klassen
        Pages 423-427
      3. The Effect of Weight Reduction on Urate Metabolism
        • B. T. Emmerson
        Pages 429-433
      4. Diet and Gout
        • N. Zöllner, A. Griebsch
        Pages 435-442
      5. Effect of Ribomononucleotides Given Orally on Uric Acid Production in Man
        • A. Griebsch, N. Zöllner
        Pages 443-449
      6. Relationship Between Gout and Arterial Hypertension
        • Aurelio Rapado
        Pages 451-459

    4. Relationship Between Carbohydrate, Lipid, and Purine Metabolism

      1. Studies on the Mechanism of Fructose-Induced Hyperuricemia in Man
        • I. H. Fox, W. N. Kelley
        Pages 463-470
      2. Observations of Altered Intracellular Phosphoribosylpyrophosphate (PP-Ribose-P) in Human Disease
        • I. H. Fox, W. N. Kelley
        Pages 471-478
      3. Human Erythrocyte Phosphoribosylpyrophosphate Content and “Generation” During a Constant Rate Infusion of Xylitol
        • W. Kaiser, K. Stocker, P.-U. Heuckenkamp
        Pages 479-482
      4. Diabetes and Uric Acid — A Relationship Investigated by the Epidemiological Method
        • Joseph B. Herman, J. H. Medalie, U. Goldbourt
        Pages 483-484
      5. Metabolic and Glucose Load Studies in Uric Acid, Oxalic and Hyperparathyroid Stone Formers
        • P. O. Schwille, D. Scholz, G. Hagemann, A. Sigel
        Pages 485-494
      6. Observations Concerning the Incidence of Disturbance of Lipid and Carbohydrate Metabolism in Gout
        • O. Frank
        Pages 495-498
      7. Gout and Hyperlipidaemia
        • T. Gibson, R. Grahame
        Pages 499-508
      8. Lipid and Purine Metabolism in Benign Symmetric Lipomatosis
        • M. M. Müller, O. Frank
        Pages 509-516
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Keywords

About this book

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.

Editors and Affiliations

  • Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling, Andre Vries

  • Department of Medicine, Duke University Medical Center, Durham, USA

    James B. Wyngaarden

Bibliographic Information

  • Book Title: Purine Metabolism in Man

  • Book Subtitle: Biochemistry and Pharmacology of Uric Acid Metabolism

  • Editors: Oded Sperling, Andre Vries, James B. Wyngaarden

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4757-1433-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1974

  • Softcover ISBN: 978-1-4757-1435-7Published: 15 April 2013

  • eBook ISBN: 978-1-4757-1433-3Published: 11 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXV, 476

  • Topics: Biochemistry, general

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