Cell Impairment in Aging and Development

1. Front Matter

   Pages i-xv

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2. Cell Ageing: Chairman’s Introduction

   • L. M. Franks

   Pages 1-5

3. The Effect of Hydrocortisone on DNA Synthesis and Cell Division during Aging in Vitro

   • V. J. Cristofalo

   Pages 7-22

4. Proliferative and Functional Impairment of Pancreatic Epithelial Cells Maintained in Vitro

   • Robert J. Hay

   Pages 23-39

5. The Use of Arrested Populations of Human Diploid Fibroblasts for the Study of Senescence in Vitro

   • Robert T. Dell’Orco

   Pages 41-49

6. Relationship between Cell Kinetic Changes and Metabolic Events during Cell Senescence in Vitro

   • A. Macieira-Coelho, E. Loria, L. Berumen

   Pages 51-65

7. Do Hyperplastoid Cell Lines “Differentiate Themselves to Death”?

   • G. M. Martin, C. A. Sprague, T. H. Norwood, W. R. Pendergrass, P. Bornstein, H. Hoehn et al.

   Pages 67-90

8. Time-Lapse Cinemicrophotographic Studies of Cell Division Patterns of Human Diploid Fibroblasts (WI-38) during their in Vitro Lifespan

   • P. Marlene Absher, Richard G. Absher, William D. Barnes

   Pages 91-105

9. Characteristics of Proliferative Cells from Young, Old, and Transformed WI 38 Cultures

   • Phillip D. Bowman, Charles W. Daniel

   Pages 107-122

10. Alterations in Chromatin Functions during Aging in Vitro

    • Jon M. Ryan

    Pages 123-136

11. Growth-Promoting Alpha-Globulin and Ageing

    • Jiří Michl, Mirosalv Tolar, Věra Spurná, Dagmar Řezáčová

    Pages 137-146

12. Cell Surface Alterations and “in Vitro” Aging of Animal Cells

    • R. Azencott, C. Hughes, Y. Courtois

    Pages 147-153

13. Changes in Lysosomes during Ageing of Parenchymal and Non-Parenchymal Liver Cells

    • D. L. Knook, E. C. Sleyster, M. J. van Noord

    Pages 155-169

14. The Effect of Age on Mitochondrial Ultrastructure and Enzymes

    • P. D. Wilson, L. M. Franks

    Pages 171-183

15. Creatinephosphokinase in Human Diploid Cell Lines

    • M. Macek, H. Tomášová, J. Hurych, D. Řezáčová

    Pages 185-192

16. Cytochemical and Cytogenetic Findings in Five Human Leukocyte Long-Term Cultures (LAHL) of Different Origin

    • V. Pössnerová, M. Macek, F. Heřmanský, J. Fortýnová, S. Jeník, J. Holý et al.

    Pages 193-205

17. Enzymatic Differences between Short-Lived and Long-Lived Drosophila Strains

    • Jaroslava Skřivanová, Františka A. Gadirová, Emma Holečková

    Pages 207-213

18. Cell Ageing in the Intestinal Tract

    • C. Rowlatt

    Pages 215-217

19. Studies on the Proliferative Capacity of Mouse Spleen Cells in Serial Transplantation

    • J. W. I. M. Simons, C. van den Broek

    Pages 219-233

20. On the Ageing of Intermitotic Cells — Investigations on Enterocytes and Hepatocytes

    • G. Leutert, W. Rotzsch, W. Beier

    Pages 235-245

lar aging, to which this model contributes, has grown. Apart from reports on work in this almost "classical" diploid cell system, the symposium presents studies using different biological systems with results that have been rewarding as information is obtained on patterns of change that are common to more than one experimental system. Indeed, in recent years much more has been learned about the fate of all different types of intermitotic and postmitotic cells in situ. The symposium has also presented contributions dealing, not directly with aging but with early ontogeny; such information on early developmental changes should certainly shed light on some of the mechanisms involved in aging. We are cognizant of the fact that environmental influences resulting from the complexities of modern civilization may have results that only occur much later, and profoundly affect the lifespan of the organism. There remain, of course, many unanswered questions. Whether there is "physiological" as opposed to "pathological" aging; whether "old" cultures living in unchanged, although not exhausted, medium, are degenerating, not aging; what is involved when "old" fragment cultures regenerate after excision by filling the wound with "young" cells; why some tumor cells in vivo as well as in vitro die while others live; all are questions~eserving of our attention.

• aging
• attention
• bone
• cell
• cells
• development
• fat
• kidney
• retina
• tissue
• tumor

• Wistar Institute of Anatomy and Biology, Philadelphia, USA

  Vincent J. Cristofalo

• Institute of Physiology, Czechoslovak Academy of Sciences, Prague 4, Czechoslovakia

  Emma Holečková

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