Limbic Mechanisms

1. Front Matter

   Pages i-xv

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2. The Limbic System Concept

   1. Challenges of the Papez Heritage

      • Paul D. MacLean

      Pages 1-15

   2. A Casual Glimpse of Evolution and Development Relating to the Limbic System

      • Robert B. Livingston

      Pages 17-21

   3. Embryogenesis and Phylogenesis in the Limbic System

      • Jay B. Angevine Jr.

      Pages 23-46

   4. Synapse Formation and Plasticity in the Developing Dentate Gyrus

      • Carl W. Cotman

      Pages 47-65

   5. Re-Establishment of Terminal Patterns in the Adult Rat Hippocampus by Grafted Monoaminergic Neurons

      • Anders Björklund, Ulf Steveni

      Pages 67-74

   6. Crossroads of Limbic and Striatal Circuitry: Hypothalamo-Nigral Connections

      • Walle J. H. Nauta, Valerie B. Domesick

      Pages 75-93

   7. The Olfactory Cortex and the Ventral Striatum

      • Lennart Heimer

      Pages 95-187

   8. Inputs and Outputs of the Amygdala: What the Amygdala is Trying to Tell the Rest of the Brain

      • P. Gloor

      Pages 189-209

   9. The Role of the Limbic System in Neuroendocrine Regulation

      • J. O. Willoughby, J. B. Martin

      Pages 211-261

   10. The Biochemical Pharmacology of the Limbic System: Neuroleptic Drugs

       • K. G. Lloyd

       Pages 263-305

   11. The Meso-Telencephalic Dopamine Neuron System: A Review of Its Anatomy

       • Anders Björklund, Olle Lindvall

       Pages 307-331

   12. Monoaminergic Systems in the Human Limbic Brain

       • I. J. Farley, K. S. Price, O. Hornykiewicz

       Pages 333-349

   13. Recollections of James Papez and Comments on the Evolution of the Limbic System Concept

       • Paul I. Yakovlev

       Pages 351-354

3. The Kindling Phenomenon: A Dynamic Model of Neural Plasticity and Induced Limbic System Dysfunction

   1. Synaptic Change in the Limbic System; Evidence from Studies Using Electrical Stimulation with and without Seizure Activity

      • G. V. Goddard, B. L. McNaughton, R. M. Douglas, C. A. Barnes

      Pages 355-368

   2. The Clinical Relevance of Kindling: Species, Brain Sites and Seizure Susceptibility

      • Juhn A. Wada

      Pages 369-388

   3. The Endogenous Psychoses: A Reflection of Lateralized Dysfunction of the Anterior Limbic System

      • P. Flor-Henry

      Pages 389-404

   4. Normal and Abnormal Limbic System Mechanisms of Emotive Biasing

      • Robert E. Adamec

      Pages 405-455

   5. A Further Investigation into the Mechanisms Underlying the Kindling Phenomenon

      • R. Racine, J. Zaide

      Pages 457-493

   6. Kindling and Memory: The Adrenal System and the Bisected Brain

      • Dan C. McIntyre

      Pages 495-506

This volume records the proceedings of a Limbic System Sympos­ ium held at the University of Toronto, November 5-6th, 1976 as a satellite event to the Sixth Annual Meeting of the Society of Neuroscience. The Symposium was designed in part as a tribute to James Papez on the 40th anniversary of the publication of his epochal paper "A Proposed Mechanism of Emotion". Papers by MacLean, Yakovlev, and Angevine provide personal recollections of Papez and an assessment of the significant contri­ bution he made to breaking down the still formidable barriers that separate our concepts of brain, mind, emotion, and behavior. Against this background subsequent speakers presented new information that further illuminates the anatomical, physiological and biochemical mechanisms underlying limbic system function. Viewed in juxtaposition this new information from "disparate" fields of neuroscience provides an increasingly coherent picture of the neuronal organization subserving a dynamic limbic system that we can now begin to visualize in operational and transactional terms. The final section of the symposium focusses on the recently identified "kindling" phenomenon which is viewed as a general model of neural plasticity and more particularly as a model of experi­ mentally induced limbic system dysfunction. Using this model it is possible to display, analyse, and experimentally manipulate long lasting changes in limbic system activity, which develop over ex­ tended periods of time and are expressed in a variety of behavioral end points involving learning and memory, seizure activity, and changes in emotionality and behavior.

• brain
• evolution
• experiment
• information
• neuroscience
• organization
• system
• time
• university

• University of Toronto, Canada

  Kenneth E. Livingston, Oleh Hornykiewicz

• The Wellesley Hospital, Toronto, Canada

  Kenneth E. Livingston

• Institute of Biochemical Pharmacology, University of Vienna, Austria

  Oleh Hornykiewicz

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