Skip to main content
SpringerLink
Log in

Advanced Topics on Radiosensitizers of Hypoxic Cells

  • Book
  • © 1982

Overview

Editors:
  1. A. Breccia

    1. University of Bologna, Bologna, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. C. Rimondi

    1. Malpighi Hospital, Bologna, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. G. E. Adams

    1. Institute of Cancer Research, Sutton, England

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 43)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. The Chemistry of Nitroimidazole Hypoxic Cell Radiosensitizers

    • C. E. Smithen, C. R. Hardy
    Pages 1-47

  3. Molecular Structure and Biological Activity of Hypoxic Cell Radiosensitizers and Hypoxic-Specific Cytotoxins

    • Peter Wardman
    Pages 49-75

  4. Physico-Chemical Methods for Investigating Mechanisms of Radiosensitization

    • F. Busi, A. Breccia
    Pages 77-89

  5. Radiation-Induced and Metabolism-Induced Reactions of Hypoxic Sensitizers with Cellular Molecules

    • J. D. Chapman, J. Ngan-Lee, C. C. Stobbe, B. E. Meeker
    Pages 91-103

  6. Radiation-Induced Cellular DNA Damage and Repair, and the Effect of Hypoxic Cell Radiosensitizers

    • E. Martin Fielden, O. Sapora
    Pages 105-117

  7. Biological Methods for Studying Radiosensitization

    • Juliana Denekamp
    Pages 119-142

  8. Lipophilicity and the Pharmacokinetics of Nitroimidazoles

    • Paul Workman
    Pages 143-163

  9. Pharmacokinetic Studies on Some Novel (2-Nitro-1-Imidazolyl) Propanolamine Radiosensitizers

    • M. R. L. Stratford, A. I. Minchinton, F. A. Stewart, V. S. Randhawa
    Pages 165-169

  10. The Effect of Dexamethasone on the Neurotoxicity of Nitroimidazole Compounds

    • R. C. Urtasun, H. Tanasichuk, J. Partington, D. Koziol, J. Allalunis, R. Turner
    Pages 171-184

  11. Radiosensitizers with Hyperfractionation in Radiotherapy

    • C. Rimondi
    Pages 185-196

  12. The Design of Clinical Trials and Clinical Toxicology of the Nitroimidazole Misonidazole in Phase I Testing in the Radiation Therapy Oncology Group

    • Theodore L. Phillips, Todd H. Wasserman
    Pages 197-209

  13. Misonidazole Clinical Trials in the United States Radiation Therapy Oncology Group (RTOG)

    • Todd H. Wasserman, JoAnn Stetz, Theodore L. Phillips
    Pages 211-227

  14. Misonidazole and Desmethylmisonidazole in Clinical Radiotherapy

    • S. Dische
    Pages 229-237

  15. Prospects for New Hypoxic Cell Radiosensitizers

    • J. G. Schwade, D. A. Pistenma, T. L. Phillips
    Pages 239-246

  16. Clinical Experiments with Radiosensitizing Drugs in Italy

    • C. Rimondi
    Pages 247-248

  17. Multiple Daily Fractionation (MDF) in Association with Misonidazole (MIS): A Two-Year Experience with Head and Neck Cancer

    • G. Arcangeli, F. Mauro, C. Nervi
    Pages 249-260

  18. Clinical Trials and Preliminary Results Obtained by Association of Electroaffinic Hypoxic Cell Radiosensitizing Drugs (Misonidazole and Metronidazole) with Radiotherapy (Telecobalt Therapy) for the Treatment of Some Types of Neoplastic Diseases at a Locally Advanced Stage

    • L. Busutti
    Pages 261-268

  19. Control of the Immunological Status of Neoplastic Patients undergoing Telecobalt Therapy in Association with Radiosensitizers

    • A. Petralia
    Pages 269-269

  20. The Association of Radiotherapy with Radiosensitizing Drugs in the Treatment of Soft Tissue Sarcomas (Preliminary Studies)

    • F. Coucourde, G. F. Frezza, P. Frezza, F. Fortunato, D. Zarrilli, G. Cornelia et al.
    Pages 271-274
Back to top

Keywords

About this book

In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clinical Application." Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give the conference the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved a proposal which also came from the Faculty of Pharmacy, to offer an advanced course on the topic "Radiosensitizers of Hypoxic Cells This course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the conference and the course are closely inter-related, it was logical to plan the conference as part of the overall course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy, and the development of drugs for use in cancer in general.

Editors and Affiliations

  • University of Bologna, Bologna, Italy

    A. Breccia

  • Malpighi Hospital, Bologna, Italy

    C. Rimondi

  • Institute of Cancer Research, Sutton, England

    G. E. Adams

Bibliographic Information

  • Book Title: Advanced Topics on Radiosensitizers of Hypoxic Cells

  • Editors: A. Breccia, C. Rimondi, G. E. Adams

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4757-0399-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1982

  • Softcover ISBN: 978-1-4757-0401-3Published: 12 April 2013

  • eBook ISBN: 978-1-4757-0399-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 284

  • Topics: Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation