Immunologic Defects in Laboratory Animals 1

1. Front Matter

   Pages i-xx

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2. Defects of Immune Maturation

   1. Front Matter

      Pages 1-1

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   2. Immunologic Unresponsiveness in Fetal and Neonatal Mammals

      • R. B. Ashman

      Pages 3-15

3. Incomplete Immune Function in Normal Animals

   1. Front Matter

      Pages 17-17

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   2. Genetic Regulation of High and Low Immunoresponsiveness

      • Denise Mouton, Claude Stiffel, Guido Biozzi

      Pages 19-47

4. Immunohematologic Abnormalities

   1. Front Matter

      Pages 49-49

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   2. Hematopoietic Stem Cell Differentiation and Its Role in Osteopetrosis

      • Wieslaw Wiktor-Jedrzejczak, Regina R. Skelly, Aftab Ahmed

      Pages 51-77

   3. The W/W ^v Mouse

      • Saul J. Sharkis, Wieslaw Wiktor-Jedrzejczak, Aftab Ahmed

      Pages 79-97

   4. The Murine Chediak-Higashi Mutation and Other Murine Pigmentation Mutations

      • E. J. Brandt, R. T. Swank, E. K. Novak

      Pages 99-117

   5. Cyclic Hematopoiesis in Gray Collie Dogs

      • William P. Hammond IV, David C. Dale

      Pages 119-136

5. B-Cell Defects

   1. Front Matter

      Pages 137-137

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   2. Inherited Dysgammaglobulinemia of Chickens

      • Albert A. Benedict, M. Eric Gershwin, Hans Abplanalp

      Pages 139-161

   3. B-Lymphocyte Development and Heterogeneity

      • Irwin Scher

      Pages 163-190

   4. The Significance of Hereditary Asplenia for Immunologic Competence

      • Wanda Lizak Welles, Jack R. Battisto

      Pages 191-212

6. T-Cell Defects

   1. Front Matter

      Pages 213-213

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   2. Deficient and Sufficient Immune Systems in the Nude Mouse

      • Berenice Kindred

      Pages 215-265

   3. Athymic Nude Rats

      • Michael F. W. Festing

      Pages 267-283

   4. The Hairless Immune-Deficient Guinea Pig

      • John L. O’Donoghue, Carolyn Reed

      Pages 285-296

   5. Hereditarily Athymic—Asplenic (Lasat) Mice

      • Kent L. Erickson, M. Eric Gershwin

      Pages 297-308

   6. Immunologic and Hematologic Deficiencies of the Hypopituitary Dwarf Mouse

      • Rene J. Duquesnoy, Grete M. Pedersen

      Pages 309-324

Tiselius demonstrated that the immunologically active components of immune sera migrated electrophoretically in the gamma globulin region. His findings illuminated the classic observations of Jenner regarding development of resistance to infection, and those of von Pirquet, Pasteur, and Arthus regarding the transfer and specificity of resistance. Conceptual integration of these observations provided the impetus for the present modern era of immunology. Subsequent to Tiselius's work, multiple, rapid advances have occurred in the study of congenital and acquired immune deficiency states in mice, chickens, and humans. These studies have readily demonstrated that the immunologic ability of an organ­ ism to protect itself from environmental influences is a prerequisite for survival. Indeed, this necessity for protection from microenvironmental influences has promoted the evolu­ tionary development of immunologic diversification, namely, host dependence upon a sophisticated, multifaceted network of cells and effector mechanisms responsible for the clearance and neutralization of toxins and potentially harmful pathogens. The obligate dependence of animals upon the functional integrity of their immunologic systems is illus­ trated by the ready invasion of ubiquitous organisms when the host is in a state of immune defense derangement. Nevertheless, derangements in immune function can range from par­ tial to complete and can be compatible with survival. The consequences of such derange­ ments run the gamut from subclinical disease to inevitable mortality.

• Laboratory
• Mamma
• Tumor
• anatomy
• biology
• cells
• development
• immunology
• infection
• infectious disease
• mortality
• mouse
• pathology
• physiology
• resistance

• University of California School of Medicine, Davis, USA

  M. Eric Gershwin

• Food and Drug Administration, Bethesda, USA

  Bruce Merchant

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