Dopamine Receptor Agonists

1. Front Matter

   Pages i-xxv

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2. Dopamine Receptors

   1. Front Matter

      Pages 1-1

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   2. Pharmacological and Biochemical Characterization of Two Categories of Dopamine Receptor

      • John W. Kebabian

      Pages 3-22

   3. Radioligand Binding Studies of Agonist Interactions with Dopamine Receptors

      • I. Creese, S. E. Leff, D. R. Sibley, M. W. Hamblin

      Pages 23-64

   4. Quantitative Assay of Dopamine Receptor Subtypes

      • Rita M. Huff, Perry B. Molinoff

      Pages 65-86

   5. Structure—Activity Relationships of Dopamine Receptor Agonists

      • Carl Kaiser

      Pages 87-137

   6. Peripheral Dopamine Receptors

      • M. G. Bogaert, W. A. Buylaert, R. A. Lefebvre, J. L. Willems

      Pages 139-155

   7. Pharmacological Significance of Pre- and Postsynaptic Dopamine Receptors

      • Salomon Z. Langer, Sonia Arbilla

      Pages 157-176

3. Dopamine Agonist Function and Pharmacology

   1. Front Matter

      Pages 177-177

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   2. Dopamine

      • N. H. Neff, M. Hadjiconstantinou, Z. Lackovic

      Pages 179-194

   3. Vascular Dopamine and Dopamine Receptor Agonists

      • Barry A. Berkowitz, Robert Erickson, Bodgan Zabko-Potavpovich, Eliot H. Ohlstein

      Pages 195-208

   4. Dopamine Receptor Agonists and Hypertension

      • Mustafa F. Lokhandwala, Richard J. Barrett

      Pages 209-223

4. Critical Concepts of Physiological and Molecular Mechanisms of Cardiovascular and Renal Function

   1. Front Matter

      Pages 225-225

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   2. Role of Inflammatory Cells in Metabolic and Cellular Alterations Underlying the Exaggerated Renal Prostaglandin and Thromboxane Synthesis in Ureter Obstruction

      • Philip Needleman

      Pages 227-235

   3. The Kidney and Hypertension

      • Arthur C. Guyton, R. Davis Manning, Thomas E. Lohmeier, John E. Hall

      Pages 237-258

   4. Molecular Mechanisms of Vasodilatation

      • Louis J. Ignarro, Carl A. Gruetter, Albert L. Hyman, Philip J. Kadowitz

      Pages 259-288

5. Clinical Applications

   1. Front Matter

      Pages 289-289

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   2. The Relationship of Receptor Actions of Dopamine Agonists to Their Clinical Effects

      • Leon I. Goldberg

      Pages 291-301

   3. Hemodynamic Factors Involved in the Regulation of Sodium Balance

      • Jay H. Stein

      Pages 303-316

   4. Dopaminergic Mechanisms in the Control of Aldosterone Secretion

      • Robert M. Carey

      Pages 317-332

Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner­ vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg­ ulation in causing disease and the utility of dopamine agonists and an­ tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con­ sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad­ vances that are occurring in the field of pharmacology at large as a con­ sequence of the involvement of an ever-larger number of scientific dis­ ciplines in the study of drug action.

• cardiovascular system
• dopamine
• drug
• kidney
• neurotransmitter
• pharmacology
• research
• treatment

• Smith Kline & French Laboratories, Philadelphia, USA

  George Poste, Stanley T. Crooke

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