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Immunological Adjuvants and Vaccines

  • Book
  • © 1989

Overview

Editors:
  1. Gregory Gregoriadis

    1. Royal Free Hospital School of Medicine, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Anthony C. Allison

    1. Syntex Research, Palo Alto, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. George Poste

    1. Smith Kline French Laboratories, Philadelphia, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 179)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-viii
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  2. Antigens and Adjuvants for a New Generation of Vaccines

    • Anthony C. Allison
    Pages 1-12

  3. Structural and Functional Studies on MHC-Peptide Antigen Interactions

    • Howard M. Grey, Søren Buus, Alessandro Sette
    Pages 13-20

  4. Role of Interferon Gamma in the Priming of Human Accessory Cells for Autocrine Secretion of Monokines (IL-1 and TNF) and HLA Class II Gene Expression

    • J. L. Virelizier, F. Arenzana-Seisdedos, S. C. Mogensen
    Pages 21-26

  5. Chemical Events in Immune Induction: Evidence for a Covalent Intercellular Reaction Essential in Antigen-Specific T-Cell Activation

    • J. Rhodes
    Pages 27-34

  6. Aluminium Salts: Perspectives in their use as Adjuvants

    • R. Bomford
    Pages 35-41

  7. Saponins as Immunoadjuvants

    • R. Bomford
    Pages 43-46

  8. The Immunoadjuvant Dimethyldioctadecylamonium Bromide

    • H. Snippe, C. A. Kraaijeveld
    Pages 47-59

  9. Bacterial Endotoxins: Relationships Between Chemical Structure and Biological Activity

    • Ernst Th. Rietschel, Lore Brade, Ulrich Schade, Ulrich Seydel, Ulrich Zähringer, Harald Loppnow et al.
    Pages 61-74

  10. Recombinant Gamma Interferon as an Immunological Adjuvant

    • J. H. L. Playfair, A. W. Heath, J. B. De Souza
    Pages 75-78

  11. The Immunoadjuvant Action of Liposomes: Role of Structural Characteristics

    • Gregory Gregoriadis, Lloyd Tan, Qifu Xiao
    Pages 79-94

  12. Immunoadjuvant Action of Liposomes: Mechanisms

    • Nico van Rooijen, Donghui Su
    Pages 95-106

  13. Liposomal Vaccine to Streptococcus Pneumoniae Type 3 and 14

    • H. Snippe, A. F. M. Verheul, J. E. G. van Dam
    Pages 107-122

  14. Liposomes as Carriers of Vaccines: Development of a Liposomal Malaria Vaccine

    • Carl R. Alving, Robert L. Richards, Michael D. Hayre, Wayne T. Hockmeyer, Robert A. Wirtz
    Pages 123-131

  15. Nonionic Block Copolymer Surfactants as Immunological Adjuvants: Mechanisms of Action and Novel Formulations

    • Robert L. Hunter, Beth Bennett, Devery Howerton, Steve Buynitzky, Irene J. Check
    Pages 133-144

  16. Use of Syntex Adjuvant Formulation to Augment Humoral Responses to Hepatitis B Virus Surface Antigen and to Influenza Virus Hemagglutinin

    • Noelene E. Byars, Gayle Nakano, Mary Welch, Anthony C. Allison
    Pages 145-152

  17. Immunostimulating Complex (ISCOM)

    • B. Morein, K. Lövgren, S. Höglund
    Pages 153-161

  18. Recombinant Sub-Unit and Peptide Viral Vaccines

    • F. Brown
    Pages 163-173

  19. Synthetic Antigens and Vaccines

    • Ruth Arnon
    Pages 175-185

  20. The Development and Preliminary Clinical Evaluation of an Antifertility Vaccine

    • P.D. Griffin
    Pages 187-194
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Keywords

About this book

Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-and­ mouth, Marek's and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organ­ isms but these have been largely replaced by attenuated or killed organisms or by purified components (subunits) thereof. More recently, developments in recombinant DNA techniques, the advent of monoclonal antibodies and progress in our understanding of the immunological structure of proteins, have laid the foundations for a new generation of vaccines. For instance, subuni t vaccines have been produced through gene cloning and a number of peptides mimicking small regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies, have been synthes­ ized. Such vaccines are defined at the molecular level, can elicit immune responses controlling specific infectious organisms and are, thus, potent­ ially free of the problems inherent in conventional ones. However, because subunit and peptide vaccines are only weakly or non-immunogenic, they re­ quire the presence of immunological adjuvants. These are a diverse array of agents that promote specific humoural and/or cell-mediated immunity responses to antigens. This book contains the proceedings of the 1st NATO Advanced Studies Institute "Immunological Adjuvants and Vaccines" held in Cape Sounion Beach, Greece during 24 June-5 July, 1988.

Editors and Affiliations

  • Royal Free Hospital School of Medicine, London, UK

    Gregory Gregoriadis

  • Syntex Research, Palo Alto, USA

    Anthony C. Allison

  • Smith Kline French Laboratories, Philadelphia, USA

    George Poste

Bibliographic Information

  • Book Title: Immunological Adjuvants and Vaccines

  • Editors: Gregory Gregoriadis, Anthony C. Allison, George Poste

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4757-0283-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4757-0285-9Published: 12 December 2012

  • eBook ISBN: 978-1-4757-0283-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 244

  • Number of Illustrations: 17 b/w illustrations

  • Topics: Immunology, Pharmacology/Toxicology, Biochemistry, general

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