Coxsackieviruses

1. Front Matter

   Pages i-xx

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2. Classification and General Properties

   • Brian W. J. Mahy

   Pages 1-18

3. The Genome of the Group B Coxsackieviruses

   • Steven Tracy

   Pages 19-33

4. Replication

   • Nando K. Chatterjee

   Pages 35-50

5. Perspectives on Cellular Receptors as Determinants of Viral Tropism

   • Richard L. Crowell, Burton J. Landau, Kuo-Hom Lee Hsu, Maggie Schultz

   Pages 51-63

6. The Role of Interferon in Picornavirus Infections

   • Ferdinando Dianzani, Maria R. Capobianchi, Donatella Matteucci, Mauro Bendinelli

   Pages 65-80

7. Interactions with the Immune System

   • Mauro Bendinelli, Pier Giulio Conaldi, Donatella Matteucci

   Pages 81-102

8. The Role of Immune Mechanisms in Pathogenesis

   • Sally Ann Huber

   Pages 103-116

9. Application of Monoclonal Antibodies to the Study of Coxsackieviruses

   • Bellur S. Prabhakar

   Pages 117-134

10. Host Conditions Affecting the Course of Coxsackievirus Infections

    • Roger M. Loria

    Pages 135-157

11. The Possible Role of Viral Variants in Pathogenesis

    • Charles J. Gauntt

    Pages 159-179

12. Persistent Infections

    • David P. Schnurr, Nathalie J. Schmidt

    Pages 181-201

13. New Approaches to Laboratory Diagnosis

    • Rüdiger Dörries

    Pages 203-219

14. General Pathogenicity and Epidemiology

    • Norman R. Grist, Daniel Reid

    Pages 221-239

15. Coxsackievirus Infection in Children under Three Months of Age

    • Mark H. Kaplan

    Pages 241-251

16. Myocarditis

    • Milagros P. Reyes, A. Martin Lerner

    Pages 253-270

17. Relationship of Coxsackievirus to Cardiac Autoimmunity

    • Kirk W. Beisel, Noel R. Rose

    Pages 271-292

18. The Impact of Recombinant DNA Technology on the Study of Enterovirus Heart Disease

    • Reinhard Kandolf

    Pages 293-318

19. Neurologic Disorders

    • Eleanor J. Bell, Fakhry Assaad, Karin Esteves

    Pages 319-337

20. Mucocutaneous Syndromes

    • Giovanni Rocchi, Antonio Volpi

    Pages 339-349

It is now just 40 years since coxsackieviruses were first isolated by Dalldorf and Sickles in the "eponymous" town of Coxsackie, New York. Yet the overall contribution of coxsackieviruses to clinically evident dis­ ease of humans is still largely an open problem. Following their discov­ ery, coxsackieviruses were under intense clinical and laboratory scrutiny for a long time. Because of their relationship to polioviruses, the under­ standing of their structure, biochemistry, biology, and epidemiology ad­ vanced rapidly as a result of the formidable efforts that eventually led to the defeat of poliomyelitis. The ability of these viruses to infect mice permitted dissection of their pathogenicity in an experimental host and elucidation of conditions that influence its expression. Coxsackieviruses have been progressively associated with an increasing array of widely diverse human diseases. However, only some of the suggested causal correlations have been substantiated with satisfactory certainty. For others, conclusive evidence has so far resisted investigation. Most impor­ tant, among the latter are chronic maladies, such as dilated car­ diomyopathy and juvenile diabetes, that demand consideration. In recent times, there has been a partial eclipse of the subject of coxsackieviruses in the medical literature. In addition to the difficulties encountered in pinpointing their pathogenic potential, possible reasons include the general decline of interest in enteroviruses, which ensued after the conquest of poliomyelitis, and the continuous appearance in the limelight of new, more esoteric, and therefore more "appealing" viruses.

• Antigen
• Pathogene
• Polypeptide
• Virus
• autoimmunity
• infection
• infections
• temperature
• viral infection
• infectious diseases

• University of Pisa, Pisa, Italy

  Mauro Bendinelli

• University of South Florida, Tampa, USA

  Herman Friedman

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