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Transition States of Biochemical Processes

  • Book
  • © 1978

Overview

Editors:
  1. Richard D. Gandour

    1. Department of Chemistry, Louisiana State University, Baton Rouge, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard L. Schowen

    1. Department of Chemistry, University of Kansas, Lawrence, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xix
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  2. The Role of the Transition State in Chemical and Biological Catalysis

    1. Front Matter

      Pages 1-1
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    2. Scope and Limitations of the Concept of the Transition State

      • Elizabeth K. Thornton, Edward R. Thornton
      Pages 3-76

    3. Catalytic Power and Transition-State Stabilization

      • Richard L. Schowen
      Pages 77-114

  3. Approaches to the Determination of Biochemical Transition-State Structures and Properties

    1. Front Matter

      Pages 115-117
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    2. Quantum-Mechanical Approaches to the Study of Enzymic Transition States and Reaction Paths

      • Gerald M. Maggiora, Ralph E. Christoffersen
      Pages 119-163

    3. Primary Hydrogen Isotope Effects

      • Judith P. Klinman
      Pages 165-200

    4. Secondary Hydrogen Isotope Effects

      • John L. Hogg
      Pages 201-224

    5. Solvent Hydrogen Isotope Effects

      • Katharine B. J. Schowen
      Pages 225-283

    6. Heavy-Atom Isotope Effects in Enzyme-Catalyzed Reactions

      • Marion H. O’Leary
      Pages 285-316

    7. Magnetic-Resonance Approaches to Transition-State Structure

      • Albert S. Mildvan
      Pages 317-338

    8. Mapping Reaction Pathways from Crystallographic Data

      • Eli Shefter
      Pages 339-352

  4. Studies of Transition-State Properties in Enzymic and Related Reactions

    1. Front Matter

      Pages 353-353
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    2. Transition-State Properties in Acyl and Methyl Transfer

      • Mohamed F. Hegazi, Daniel M. Quinn, Richard L. Schowen
      Pages 355-428

    3. Transition States for Hydrolysis of Acetals, Ketals, Glycosides, and Glycosylamines

      • E. H. Cordes, H. G. Bull
      Pages 429-465

    4. Decarboxylations of β-Keto Acids and Related Compounds

      • Ralph M. Pollack
      Pages 467-492

    5. The Mechanism of Phosphoryl Transfer

      • S. J. Benkovic, K. J. Schray
      Pages 493-527

    6. Intramolecular Reactions and the Relevance of Models

      • Richard D. Gandour
      Pages 529-552

  5. Applications of Biochemical Transition-State Information

    1. Front Matter

      Pages 553-553
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    2. Transition-State Affinity as a Basis for the Design of Enzyme Inhibitors

      • Richard Wolfenden
      Pages 555-578
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Keywords

About this book

The transItIOn-state theory has been, from the point of its inception, the most influential principle in the development of our knowledge of reaction mechanisms in solution. It is natural that as the field of biochemical dynamics has achieved new levels of refinement its students have increasingly adopted the concepts and methods of transition-state theory. Indeed, every dynamical problem of biochemistry finds its most elegant and economical statement in the terms of this theory. Enzyme catalytic power, for example, derives from the interaction of enzyme and substrate structures in the transition state, so that an understanding of this power must grow from a knowledge of these structures and interactions. Similarly, transition-state interactions, and the way in which they change as protein structure is altered, constitute the pivotal feature upon which molecular evolution must turn. The complete, coupled dynamical system of the organism, incorporating the transport of matter and energy as well as local chemical processes, will eventually have to yield to a description of its component transition-state structures and their energetic response characteristics, even if the form of the description goes beyond present-day transition-state theory. Finally, the importance of biochemical effectors in medicine and agriculture carries the subject into the world of practical affairs, in the use of transition-state information for the construction of ultra potent biological agents.

Editors and Affiliations

  • Department of Chemistry, Louisiana State University, Baton Rouge, USA

    Richard D. Gandour

  • Department of Chemistry, University of Kansas, Lawrence, USA

    Richard L. Schowen

Bibliographic Information

  • Book Title: Transition States of Biochemical Processes

  • Editors: Richard D. Gandour, Richard L. Schowen

  • DOI: https://doi.org/10.1007/978-1-4684-9978-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1978

  • Softcover ISBN: 978-1-4684-9980-3Published: 21 February 2013

  • eBook ISBN: 978-1-4684-9978-0Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XIX, 616

  • Number of Illustrations: 119 b/w illustrations

  • Topics: Biochemistry, general

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