Recent Advances in Biological Psychiatry

1. Front Matter

   Pages i-xv

   PDF

2. Presidential Address

   1. “Build Thee More Stately Mansions, O My Soul”

      • Ralph W. Gerard

      Pages 1-5

3. Psychopharmacology

   1. Psychotogenic N,N-Dimethylated Indole Amines and Behavior in Schizophrenic Patients

      • H. Tanimukai, R. Ginther, J. Spaide, J. R. Bueno, H. E. Himwich

      Pages 6-15

   2. Dynamic Aspects of Chlorpromazine Metabolism

      • F. W. Grant

      Pages 16-19

   3. In Vivo and In Vitro Interactions of Chlorpromazine and Melanin

      • Arthur G. Bolt, Irene S. Forrest

      Pages 20-28

   4. Biochemical Determinants in the Evaluation of Monoamine-Oxidase Inhibitors

      • Sabit Gabay, Alfred J. Valcourt

      Pages 29-41

4. Neuropharmacology

   1. Role of Water in Drug Action on Nerve

      • R. I. Ludmer, H. C. Sabelli

      Pages 42-52

   2. Structural and Histochemical Change in Ventral-Horn Cells Resulting from Sensory Deprivation

      • I. James Young, Wilbur F. Rowley

      Pages 53-73

   3. Molecular Pharmacology of Hallucinogens

      • V. S. Johnston, R. J. Bradley

      Pages 74-99

5. Psychopharmacology of Learning and Memory

   1. Learning and Memory Enhancement by Pemoline and Magnesium Hydroxide (PMH)

      • N. Plotnikoff

      Pages 102-120

   2. Diphenylhydantoin and Procainamide: Normalization of Suboptimal Learning Behavior

      • Paul Gordon

      Pages 121-133

   3. Effect of Vitamin B12 on Neuronal RNA and on Instrumental Conditioning in the Rat

      • Hildegard E. Enesco

      Pages 134-143

   4. Ictus and Amnesia

      • Iver F. Small, Joyce G. Small

      Pages 144-159

   5. Effect of Electroconvulsive Therapy on Memory in Depressive Disorders

      • William W. K. Zung, Judith Rogers, Arnold Krugman

      Pages 160-178

   6. Is There an Addressed Memory in the Nervous System?

      • J. Z. Young

      Pages 179-193

6. EEG and Neurophysiology

   1. Some Electrographic Differences Between Chronic Schizophrenic Patients and Normal Subjects

      • E. Rodin, J. Grisell, J. Gottlieb

      Pages 194-204

   2. Averaged Somatosensory Evoked Responses in Various Psychiatric Disorders

      • Charles Shagass

      Pages 205-219

   3. Correlative Behavioral and Evoked-Potential Analysis of “Inhibitory” Temporal-Lobe Function

      • Juhn A. Wada

      Pages 220-239

   4. Coded Stimulation of the Eighth Nerve as a Means of Investigating Auditory Memory

      • B. Saltzberg, R. G. Heath, C. M. Fortner, R. J. Edwards

      Pages 240-248

   5. The Role of Brain Waves in Learning and Other Integrative Functions

      • Chester W. Darrow, Gary R. Gullickson

      Pages 249-256

A method of behavioral control which utilizes nutritive sucking as the operant has been evolved in our laboratory. Using this technique we studied the role of arousal and learning in the development of environ­ mental control over earliest feeding behavior. Few of the infants in our studies were able to coordinate their sucking behavior to arbitrary operant-discrimination schedules, but when the individual pattern of suck­ ing was taken into consideration, some infants rapidly adapted to the reinforcement schedule. Data from various reinforcement schedules suggest that earliest mothering involves a mutual adaptation in which the nurturing environment approximates and then entrains the infant's feeding behavior by a perceptive manipulation of the infant's state of arousal. Coordination between the infant and its environment sets the stage for associative learning, which develops following maturation of the infant's discriminative and response capacities. The process of behavioral acquisition begins with unconditioned feeding responses, which are transformed into complex learned behavior through the mediation of an appropriately reinforcing environment. The infants studied showed individual differences in susceptibility to environmental control and in response to frustration. The relative importance of arousal and learning as determinants of infant behavior are discussed and a hypothetical model for the earliest mother-infant relationship is proposed.

• Laboratory
• adaptation
• behavior
• brain
• development
• electroencephalography (EEG)
• memory
• nervous system
• neurophysiology
• pharmacology
• physiology
• psychiatric disorder
• therapy

• Downstate Medical College, State University of New York, Brooklyn, USA

  Joseph Wortis

Policies and ethics