Vascular Endothelium in Health and Disease

1. Front Matter

   Pages i-xii

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2. Microvascular Permeability

   1. Front Matter

      Pages 1-1

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   2. The Paracellular Pathway in Capillary Endothelia

      • Magnus Bundgaard

      Pages 3-8

   3. Theoretical Modeling of Fluid Transport Through Endothelial Junctions

      • Richard Skalak

      Pages 9-16

   4. Variability in Microvascular Estimates of Capillary Surface Area for Exchange

      • Ingrid H. Sarelius, Tara A. Nealey, Terrence E. Sweeney

      Pages 17-21

   5. Atrial Natriuretic Peptide (ANP)-Induced Increase in Capillary Albumin and Water Flux

      • Virginia H. Huxley, D. Joseph Meyer Jr.

      Pages 23-31

3. Role of Endothelium in Antherogenesis

   1. Front Matter

      Pages 33-33

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   2. Computerized 3-D Reconstruction of Small Blood Vessels from High Voltage Electron-Micrographs of Thick Serial Cross Sections

      • L. Horn, W. S. Krajewski, P. K. Paul, M. J. Song, M. J. Sydor

      Pages 35-42

   3. Correlation of Laser-Doppler-Velocity Measurements and Endothelial Cell Shape in a Stenosed Dog Aorta

      • D. W. Liepsch, M. Levesque, R. M. Nerem, S. T. Moravec

      Pages 43-50

   4. Role of Hemodynamic Factors in Atherogenesis

      • Takeshi Karino, Toshihisa Asakura, Shoji Mabuchi

      Pages 51-57

   5. The Role of Arterial Endothelial Cell Mitosis in Macromolecular Permeability

      • Shu Chien, Shing-Jong Lin, Sheldon Weinbaum, Mary M. L. Lee, Kung-Ming Jan

      Pages 59-73

4. Leukocyte-Endothelium Interactions

   1. Front Matter

      Pages 75-75

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   2. The Ultrastructural Basis of Interactions between Leukocytes and Endothelium

      • F. Hammersen, A. Unterberg, E. Hammersen

      Pages 77-84

   3. Leukocyte Endothelium Adhesion and Microvascular Hemodynamics

      • Herbert H. Lipowsky, Steven D. House, John C. Firrell

      Pages 85-93

   4. White Cell-Endothelium Interaction During Postischemic Reperfusion of Skin and Skeletal Muscle

      • K. Messmer, F. U. Sack, M. D. Menger, R. Bartlett, J. H. Barker, F. Hammersen

      Pages 95-98

   5. Morphometric Studies on Human Leukocyte Granules

      • Geert W. Schmid-Schönbein, Shu Chien

      Pages 99-109

5. Prostaglandins and Hemostatic Functions of Vascular Endothelium

   1. Front Matter

      Pages 111-111

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   2. Effect of Vitamin E on Prostacyclin Production from Cultured Aortic Endothelial Cells

      • Makoto Kunisaki, Fumio Umeda, Toyoshi Inoguchi, Hiroshi Ono, Yasuhiro Sako

      Pages 113-117

   3. Prostacyclin Production in Vascular Endothelium of Patients with Blackfoot Disease

      • Oi-Tong Mak

      Pages 119-125

   4. Endothelial Cell Function in Hemostasis and Thrombosis

      • Kenneth Kun-yu Wu, Karen Frasier-Scott, Helen Hatzakis

      Pages 127-133

In recent years there has been rapid progress in research on vascular endothelium. This has led to significant advances in our understanding of the structure and function of vascular endothelium in health and disease, including such aspects as the permeability of endothelium in relation to its ultrastructural correlates, theoretical basis, regulatory factors, and role in atherogenesis; the interaction between endothelium and blood cells; the endothelial release and processing of a number of important physiological agents, such as eicosanoids, hemostatic factors, and histamine; the cell biology of endothelium with respect to the cytoskeletal apparatus, cell activation, and cell locomotion; and the role of endothelium in microcirculatory regulation in normal and pathophysiological circumstances. A Symposium on "Vascular Endothelium in Health and Disease" was held on August 5-6, 1987, at the Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China, following the 4th World Congress for Microcirculation in Japan. Experts working on various aspects of vascular endothelium came from allover the world to participate in this two-day Symposium and gave excellent presentations. This volume, embodying the proceedings of that Symposium, is a collection of the papers given by the speakers with, in many cases, further updating and new information added subsequent to the Symposium. The Institute of Biomedical Sciences (IBMS), the site of this Symposium, is a newlJl established research institution, which has vascular endothelium as one of its areas of research emphasis.

• angiogenesis
• artery
• biology
• blood
• blood cell
• cell
• cell biology
• circulation
• endothelium
• health
• hemodynamics
• regulation
• research

• Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Republic of China

  Shu Chien

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