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Molecular Biology of Brain and Endocrine Peptidergic Systems

  • Book
  • © 1988

Overview

Editors:
  1. Michel Chrétien

    1. Clinical Research Institute, Montreal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Kenneth W. McKerns

    1. International Foundation for Biochemical Endocrinology, Blue Hill Falls, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Biochemical Endocrinology (BIOEND)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Genetic Engineering of Polypeptide Hormones (Mutagenesis)

    1. Functional Dissection of a cAMP-Response Element Using Recombinant Mutations

      • Joel F. Habener, Paul J. Deutsch, James P. Hoeffler, J. Larry Jameson
      Pages 1-12

  3. Structure Activity Relationship and Peptide Drug Design

    1. Conformational Constraints in the Design of Receptor Selective Peptides: Conformational Analysis and Molecular Dynamics

      • Victor J. Hruby, Wieslaw Kazmierski, B. Montgomery Pettitt, Fahad Al-Obeidi
      Pages 13-27

    2. Angiotensin II Antagonists with Prolonged Duration of Action Possible Anti-Hypertensive Drugs

      • Emanuel Escher
      Pages 29-45

    3. New Concepts in Peptide Analog Design

      • Peter W. Schiller
      Pages 47-61

  4. Clinical and Experimental Applications of Polypeptide Hormones

    1. Neuropeptidergic Pathways as Possible Targets for the Development of New Therapeutic Agents

      • Bernard P. Roques
      Pages 63-82

    2. Combination Therapy with the Antiandrogen Flutamide and the LHRH Agonist [D-Trp6, des-Gly-NH2 10]LHRH Ethylamide in Prostate Cancer: Rationale and 5-Year Clinical Experience

      • Fernand Labrie, André Dupont, Alain Bélanger, Jacques Simard, Claude Labrie, Richard Poulin et al.
      Pages 83-101

  5. Organelle Organization and Intracellular Trafficking

    1. Proinsulin Conversion Site

      • L. Orci
      Pages 103-122

  6. Hormone and Receptor Ligand Interactions

    1. Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C

      • Takaaki Yoshimasa, Michel Bouvier, Jeffrey L. Benovic, Nourdine Amlaiky, Robert J. Lefkowitz, Marc G. Caron
      Pages 123-139

    2. Role of Glycosylation in Ligand-Receptor Interactions and Signal Transduction Mechanisms

      • M. R. Sairam
      Pages 141-158

  7. Post-Translational Processing of Peptide Hormones

    1. Molecular Structure of Neutral Endopeptidase 24.11 (Enkephalinase)

      • Philippe Crine, Guy Boileau, Alain Devault, Max Zollinger, Muriel Aubry
      Pages 159-178

    2. The Possible Role of Plasma Kallikrein in Pro-Hormone and Pro-Enzyme Processing

      • Nabil G. Seidah, Joanne Paquin, Josée Hamelin, Kathleen Metters, Suzanne Benjannet, Majambu Mbikay et al.
      Pages 179-188

    3. Sequence Analysis of the Carboxypeptidase E Precursor

      • Lloyd D. Fricker
      Pages 189-199

    4. Cellular Mechanisms of Peptide Processing: Focus on α-Amidation

      • Richard E. Mains, Victor May, Edward I. Cullen, Betty A. Eipper
      Pages 201-213

    5. The Yeast KEX1 Gene Product Acts as a Carboxypeptidase B-Like Protease in Processing Secreted Protein Precursors

      • Antony Cooper, Howard Bussey
      Pages 215-223

  8. Receptor Localization and in Situ Hybridization

    1. Regulation of mRNA in Peptidergic Systems: Quantitative and In Situ Studies

      • Stanley J. Watson, Thomas G. Sherman, Martin K. Schafer, Paresh Patel, James P. Herman, Huda Akil
      Pages 225-241

    2. Cellular and Sub-Cellular Localization of Brain Neurotensin Receptors

      • Alain Beaudet, Eva Szigethy, Jean Pierre Kessler, Corinne Dana, Jean Mazella, Emmanuel Moyse
      Pages 243-257

  9. Gonadotropins and Novel Gonadal Peptides. Isolation, Structure and Cloning

    1. Diversity of Novel Proteins in Gonadal Fluids

      • P. Manjunath, L. Baillargeon, Y. L. Marcel, N. G. Seidah, M. Chrétien, A. Chapdelaine
      Pages 259-273

    2. Biochemical and Biological Characterization of LH and FSH Expressed by Recombinant DNA Technology

      • Scott Chappel
      Pages 275-288

  10. Regulation of Neuropeptide Gene Expression

    1. DNA Binding Proteins and Their Roles in Controlling Tissue Specific Gene Expression and Responses to Second Messengers

      • Michael Karin, Mordechai Bodner, Robert Chiu, Peter Angel, David Wu, Sharon Dana et al.
      Pages 289-297
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Keywords

About this book

We had the pleasure and the great opportunity to organize a symposium on "Molecular Biology of Brain and Endocrine Peptidergic Systems" under the auspices of the Canadian Biochemical society and the International Foundation for Biochemical Endocrinology. We were indeed very happy to ass~ble a series of first rate speakers who delivered excellent papers on a variety of subjects from the synthesis of complicated peptide analogs, to the creation of trangenic mice, site-directed mutagenesis, enzyme characterization and DNA binding sites. One hundred and seventy-five participants attended the 40 conferences while having the opportunity to look at 24 posters presented by senior scientists as well as students. We, of the organizing committee, feel extremely pleased to have received an overwhelming response from such a group of scholars. We wish to express our sincere gratitude to Mrs. Diane Marcil who arranged most aspects of the meeting with efficiency. We also thank the different organizations and companies for their generous grants which made the reunion possible. We hope that the participants have gained scientifically while having a pleasant sojourn in beautiful Montreal. The organizing committee was made up of a group of dedicated people, particularly its secretary, Dr. Philippe Crine. To all speakers and sessions chairpersons, we are indebted for the excellence of their participation.

Editors and Affiliations

  • Clinical Research Institute, Montreal, Canada

    Michel Chrétien

  • International Foundation for Biochemical Endocrinology, Blue Hill Falls, USA

    Kenneth W. McKerns

Bibliographic Information

  • Book Title: Molecular Biology of Brain and Endocrine Peptidergic Systems

  • Editors: Michel Chrétien, Kenneth W. McKerns

  • Series Title: Biochemical Endocrinology

  • DOI: https://doi.org/10.1007/978-1-4684-8801-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1988

  • Softcover ISBN: 978-1-4684-8803-6Published: 03 January 2013

  • eBook ISBN: 978-1-4684-8801-2Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XI, 321

  • Topics: Diabetes

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