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Recent Advances in Chiral Separations

  • Book
  • © 1991

Overview

Editors:
  1. D. Stevenson

    1. Robens Institute of Health and Safety, University of Surrey, Guildford, Surrey, UK

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  2. I. D. Wilson

    1. ICI Pharmaceuticals, Macclesfield, Cheshire, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: The Chromatographic Society Symposium Series (CSSS)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xii
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  2. A Note on a Regulatory View of the Importance of Chiral Discrimination

    • J. W. Bridges
    Pages 1-3

  3. Is There a Rational Basis for the Selection and/or Design of Chiral Stationary Phases for High-Performance Liquid Chromatography?

    • David R. Taylor
    Pages 5-14

  4. Chromatographic Chiral Separations on Immobilised Proteins: Does High-Performance Liquid Chromatography Mirror Nature?

    • I. W. Wainer
    Pages 15-23

  5. A Note on Some Examples of Chiral High-Performance Liquid Chromatographic Resolution in the Pharmaceutical Industry

    • R. J. Collicott
    Pages 25-30

  6. The Design of Chiral Separations for β-Blocker Drugs on Pirkle High-Performance Liquid Chromatography Phases Using Achiral Derivatisation

    • A. M. Dyas, M. L. Robinson, A. F. Fell
    Pages 31-37

  7. A Note on the Use of Reciprocal Interaction in the Design of Pyrethroid Specific Chiral Stationary Phases

    • D. R. Taylor, E. Clift
    Pages 39-41

  8. Stereochemical Analysis of Chiral Alcohol, Epoxide and Sulphoxide Metabolites by Chiral Stationary Phase High-Performance Liquid Chromatography

    • D. R. Boyd, R. A. S. McMordie
    Pages 43-55

  9. Separation and Assignment of the Stereoisomers of β-(p-Chlorophenyl) Glutamic Acid by Ligand Exchange Chromatography

    • P. M. Udvarhelyi, D. C. Sunter, J. C. Watkins
    Pages 57-62

  10. A Note on Direct Separation of Mefloquine Enantiomers by Liquid Chromatography on a Urea-Linked Chiral Stationary Phase

    • F. Gimenez, F. Bertrand, M. Bouley, A. Thuillier, G. Hazebroucq, R. Farinotti
    Pages 63-66

  11. An Evaluation of Some Chiral Stationary Phases for the Separation of β-Blocker Drugs

    • G. A. Kingston, D. Stevenson
    Pages 67-76

  12. Synthesis of Aminoalcohol and Oxazolidone Chiral Stationary Phases for High-Performance Liquid Chromatography

    • W. C. Ferraz Lourenço, D. R. Taylor
    Pages 77-83

  13. The Role of Mobile Phase Additives in Developing and Optimising Separations of Water-Soluble Enantiomers by High-Performance Liquid Chromatography

    • R. M. Gaskell, B. Crooks
    Pages 85-92

  14. A Note on Chiral Ion-Pair Chromatography of Novel Basic Antihypertensive Agents

    • V. de Biasi, M. B. Evans, W. J. Lough
    Pages 93-96

  15. Optimisation of Chiral Separation of Doxazosin Enantiomers by High-Performance Liquid Chromatography on a Second Generation α1-Acid Glycoprotein Column

    • G. W. Ley, A. F. Fell, B. Kaye
    Pages 97-103

  16. Attempts to Quantify the Effect of Selected Structural Parameters on the Separation of Some N-Arylthiazoline-2-Thione and N-Arylthiazolin-2-One Atropisomers on the Chiral Stationary Phase, Cellulose Triacetate (CTAl)

    • C. Roussel, J.-L. Stein, M. Sergent, R. Phan Tan Luu
    Pages 105-108

  17. A Note on Temperature Effects on High-Performance Liquid Chromatographic Enantiomeric Resolution Using Chiral Stationary Phases Containing Trans-1,2-Diaminocyclohexane Derivatives

    • F. Gasparrini, D. Misiti, C. Villani
    Pages 109-116

  18. Enantiomer Separation on Dissolved Cyclodextrin Derivatives by High-Resolution Gas Chromatography: Thermodynamic Data of Chiral Recognition

    • Volker Schurig, Martin Jung
    Pages 117-133

  19. Chiral Chromatography on the Process Scale

    • Roger M. Smith, G. M. Hall, G. Subramanian
    Pages 135-142

  20. A Diode Laser Polarimetric High-Performance Liquid Chromatography Detector and Applications to Enantiomeric Purity Determinations and Enantioselective Reactions

    • David M. Goodall, David K. Lloyd, Zecai Wu
    Pages 143-150
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Keywords

About this book

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989. Like the preceding meeting, it was jointly organised by the Chromatographic Society and the Robens Institute of the University of Surrey in response to the continued interest in this area of separation science. Of particular interest to the organisers was the very clear change in the nature of the delegates attending this second symposium as compared with the first. At the previous meeting the majority of the delegates were composed of chromatographers with problems in the area of chiral separations who were keen to learn as much as possible about these techniques from the handful of recognised experts in this area. In this second symposium the divide between expert and novice was much less apparent, with the latter providing many interesting and useful contributions to the scientific programme in termt; of both oral and poster presentations.

Editors and Affiliations

  • Robens Institute of Health and Safety, University of Surrey, Guildford, Surrey, UK

    D. Stevenson

  • ICI Pharmaceuticals, Macclesfield, Cheshire, UK

    I. D. Wilson

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