The Renal Papilla and Hypertension

1. Front Matter

   Pages i-xxiv

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2. Introduction

   • Anil K. Mandal, Robert C. Muehrcke

   Pages 1-6

3. The Ultrastructure of the Renal Medulla and the Interstitial Cells

   • Sven-Olof Bohman

   Pages 7-33

4. Evidence for an Involvement of the Renal Papilla in Hypertension

   • E. E. Muirhead, J. A. Pitcock

   Pages 35-61

5. Studies on the Mechanism of the Renomedullary Antihypertensive Action

   • Dinko Sušić

   Pages 63-76

6. Vasodepressor Substances Extractable from Kidney Tissue

   • Basab K. Mookerjee, Ram V. Patak

   Pages 77-99

7. Renal Prostaglandin Synthesis and Metabolism in Normal and Hypertensive States

   • Catherine Limas

   Pages 101-120

8. Fatty Acid Composition and Depot Function of Lipid Droplet Triacylglycerols in Renomedullary Interstitial Cells

   • Inge Norby Bojesen

   Pages 121-147

9. Alterations in the Renal Medullary and Papillary Interstitial Cells in Experimental and Spontaneous (Essential) Hypertension

   • Anil K. Mandal, John A. Nordquist

   Pages 149-165

10. Regulation of Plasma Flow and Other Functions of the Renal Papilla in Hypertension

    • Mukul C. Ganguli

    Pages 167-186

11. Prostaglandin E2 Biosynthesis by Renomedullary Interstitial Cells

    • Randall Mark Zusman

    Pages 187-207

12. Influence of Renal Prostaglandins on Renin Release

    • Peter C. Weber, Wolfgang Siess

    Pages 209-230

13. Back Matter

    Pages 231-237

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LOUIS TOBIAN There are many reasons for suspecting that the medulla of the kidney is involved in the pathogenesis of hypertension. Although our present knowledge does not permit the assignment of a precise and exact role for the medulla, there are so many indications of its involvement that this is an appropriate time for the subject to be thoroughly reviewed, as Drs. MandaI and Bohman have done in this volume. The involvement of the renal medulla in hypertension was first strongly indicated by the studies of Eric Muirhead. Studying renoprival hyperten­ sion, he demonstrated that the injection of extracts of renal medulla could prevent this type of hypertension in the dog, rabbit, and rat. Subsequently, a number of experiments showed that implants of renal medulla could not only prevent renoprival hypertension but also greatly reduce the level of blood pressure in Goldblatt hypertension in the rat and rabbit. It was later noted that the majority of the surviving cells in these medullary implants were interstitial cells. Pitcock and Muirhead were able to culture these interstitial cells, and implants of the cultured cells lowered blood pressure in renoprival hypertension and Goldblatt hypertension, particularly in the rat. We were able to confirm these general observations by employing implants of medulla in "postsalt" hypertension. The medullary implants did indeed bring the blood pressure down.

• blood
• blood pressure
• cells
• hypertension
• implant
• kidney
• pathogenesis
• transplantation

• Veterans Administration Medical Center and University of Oklahoma College of Medicine, Oklahoma City, USA

  Anil K. Mandal

• Karolinska Institute, Stockholm, Sweden

  Sven-Olof Bohman

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