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New Trends in Pharmacokinetics

  • Book
  • © 1991

Overview

Editors:
  1. Aldo Rescigno

    1. University of Parma, Parma, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Ajit K. Thakur

    1. Hazleton Washington, Inc., Vienna, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 221)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Pharmacokinetics: Unfolding of a Concept

    • Aldo Rescigno, Bianca Maria Bocchialini
    Pages 1-25

  3. Epistemology in Pharmacokinetics

    • James S. Beck
    Pages 27-39

  4. Model: Mechanistic vs Empirical

    • Ajit K. Thakur
    Pages 41-51

  5. Statistical Foundations of Pharmacokinetic Modeling

    • D. Krewski, R. T. Burnett, W. Ross
    Pages 53-67

  6. The Usefulness of Pharmacokinetics in the Development of Antineoplastic and Anti-Aids Agents

    • Julie L. Eiseman
    Pages 69-81

  7. Physiologic Models of Hepatic Drug Elimination

    • Malcolm Rowland, Allan M. Evans
    Pages 83-102

  8. Trends in the Pharmacokinetics of Drug-Receptor Interactions

    • David E. Schafer
    Pages 103-123

  9. In Vitro Imaging

    • A. Bertrand Brill, Andrew Karellas
    Pages 125-147

  10. Imaging Techniques in Pharmacology

    • Alan J. Fischman, Robert H. Rubin, H. William Strauss
    Pages 149-167

  11. Contribution of Positron Emission Tomography to Pharmacokinetic Studies

    • B. Mazière, M. Mazière, J. Delforge, A. Syrota
    Pages 169-187

  12. Pitfalls in Pharmacokinetic Modeling of Monoclonal Antibody Biodistribution in Man

    • Giuliano Mariani, Luigi Ferrante, Aldo Rescigno
    Pages 189-202

  13. Interspecies Scaling in Pharmacokinetics

    • Kannan Krishnan, Melvin E. Andersen
    Pages 203-226

  14. Stereoselective Pharmacokinetics

    • Alberto Tajana
    Pages 227-255

  15. Stereoselectivity in Drug Disposition and Metabolism: Concepts and Mechanisms

    • Bernard Testa
    Pages 257-269

  16. Implications of Stereoselectivity in Clinical Pharmacokinetics

    • M. Eichelbaum, A. S. Gross
    Pages 271-279

  17. Pharmacokinetic Strategies in the Development of Prodrugs

    • L. P. Balant, E. Doelker, P. Buri
    Pages 281-299

  18. Carcinogenic Risk Assessment: Science or Fantasy?

    • Ajit K. Thakur, Arvind Parthasarathi
    Pages 301-314

  19. The Value of Biokinetic Data in Hazard and Risk Assessment

    • James T. Stevens, Darrell D. Sumner
    Pages 315-333

  20. Physiological Modeling and Cancer Risk Assessment

    • Kannan Krishnan, Melvin E. Andersen
    Pages 335-354
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Keywords

About this book

The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and pharmacokinetics in particular. Clinical pharmacokinetics is using new tools for probing into the "black box" once being ac­ cessible only partly through experimental techniques and, mostly through mathemati­ cal and computer means. Development of computerized scanning, positron emission tomography (PET), stereoselectivity and other techniques are now enabling investi­ gators to have better pictures of the systems they are studying. Mathematical models through computer simulation and statistical estimation, mostly due to easy access be­ cause of inexpensive yet powerful personal computers, are enabling us to investigate ultrastructures and their functional connectivity in more detail. As a consequence, new hypotheses are being formed and tested in various related fields. In clinical pharmacokinetics, mostly due to mathematical modeling, more accurate interspecies scaling of pharmacokinetic parameters and dosimetry can be done now-a-days. The concept of "a human is a bigger rat" does not necessarily fly as a consequence. Pharmacokinetic concepts are becoming powerful tools in meaningful carcinogenic and toxic risk extrapolation of different chemicals in humans. New dose delivery designs are being formulated using pharmacokinetic techniques for different pharmaceutical compounds. Investigations continue in the academia, research institutions, pharmaceutical, biotechnological, and agricultural industries in developmental and physiological aspects of different chemicals for the benefit of mankind. The idea of a school on "New Trends in Pharmacokinetics", from which the present pUblication was made possible, took shape over almost a year.

Editors and Affiliations

  • University of Parma, Parma, Italy

    Aldo Rescigno

  • Hazleton Washington, Inc., Vienna, USA

    Ajit K. Thakur

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