The Adenoviruses

1. Front Matter

   Pages i-xvii

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2. An Overview

   • Harold S. Ginsberg

   Pages 1-4

3. The Architecture of Adenoviruses

   • M. V. Nermut

   Pages 5-34

4. The Structure of the Genome

   • John S. Sussenbach

   Pages 35-124

5. The Genetic System

   • C. S. H. Young, T. Shenk, Harold S. Ginsberg

   Pages 125-172

6. Adenovirus Transcription

   • Phillip A. Sharp

   Pages 173-204

7. Structural and Nonstructural Adenovirus Proteins

   • Ulf Pettersson

   Pages 205-270

8. Adenovirus DNA Replication

   • Thomas J. Kelly Jr.

   Pages 271-308

9. Adenovirus Assembly

   • Lennart Philipson

   Pages 309-337

10. Transformation by and Oncogenicity of Human Adenoviruses

    • F. L. Graham

    Pages 339-398

11. Adenovirus—Simian Virus 40 Interactions

    • Daniel F. Klessig

    Pages 399-449

12. Adenovirus Infections in Humans

    • Stephen E. Straus

    Pages 451-496

13. Adenoviruses of Animals

    • Masahide Ishibashi, Hiroshi Yasue

    Pages 497-562

14. Adeno-Associated Virus

    • Kenneth I. Berns

    Pages 563-592

15. Back Matter

    Pages 593-605

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The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis­ covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro­ found effect on knowledge in basic virology, molecular biology, viral ge­ netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model ofthe Adenovirion ......................... . 29 32 References .......................................... .

• Polypeptide
• development
• infection
• infections
• protein
• virus
• infectious diseases

• College of Physicians and Surgeons of Columbia University, New York, USA

  Hardold S. Ginsberg

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