Biotechnological Applications of Lipid Microstructures

1. Front Matter

   Pages i-xi

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2. Biophysical Studies of Phospholipid Bilayers

   1. Molecular Modeling of the Phospholipid Bilayer

      • Bruce Paul Gaber, Mark Nagumo, William R. Light, Indira Chandrasekhar, Nagarajan Pattabiraman

      Pages 1-11

   2. Biomembranes: Structure of Biomembranes and Their Models

      • Dennis Chapman

      Pages 13-20

   3. Stereoselective Recognition in Phospholipid Monolayers

      • Edward M. Arnett, Jeffrey M. Gold, Noel Harvey, Eric A. Johnson, L. Graham Whitesell

      Pages 21-36

   4. Biradical Tetraether Lipids from Thermoacidophilic Archaebacteria

      • Annette Gulik, Vittorio Luzatti, Mario de Rosa, Agata Gambacorta

      Pages 37-45

   5. Physical Properties of Membrane Lipids Isolated from a Thermophilic Eubacterium (Thermus sp.)

      • A. Prado, M. S. da Costa, J. Laynez, V. M. C. Madeira

      Pages 47-58

   6. Time Resolved X-Ray Analysis of E. Coli Lipid and Membrane Structural Transitions

      • Jean Luc Ranck, Annette Tardieu, Lucienne Letellier, Emanuel Shechter

      Pages 59-69

3. Bilayer-Biomolecule Interactions

   1. Stabilization of Small, Unilamellar Phospholipid Vesicles by Sucrose during Freezing And Dehydration

      • Helmut Hauser, George Strauss

      Pages 71-80

   2. Surfactant-Induced Liposome Fusion: Molecular Mechanisms and Biotechnological Applications

      • Félix M. Goñi, Alicia Alonso

      Pages 81-103

   3. Molecular Mechanisms of Membrane Fusion and Applications of Membrane Fusion Techniques

      • Jan Wilschut, Janny Scholma, Toon Stegmann

      Pages 105-126

   4. The Interaction of Coenzyme Q and Vitamin E with Multibilayer Liposomes

      • Juan C. Gomez-Fernandez, Francisco J. Aranda, Jose Villalain, Antonio Ortiz

      Pages 127-139

   5. The Interaction of an Anti-Phosphorylcholine Monoclonal Antibody with Phosphorylcholine-Containing Lipids

      • María-Angeles Urbaneja, Dennis Chapman

      Pages 141-149

4. Liposomes as Delivery Systems

   1. Liposomes as a Drug Delivery System: Optimization Studies

      • Gregory Gregoriadis

      Pages 151-159

   2. Liposome-Encapsulated Hemoglobin: A Synthetic Red Cell

      • M. C. Farmer, S. A. Johnson, R. L. Beissinger, J. L. Gossage, A. B. Lynn, K. A. Carter

      Pages 161-170

   3. Progress in Development of Synthetic Erythrocytes Made by Encapsulation of Hemoglobin

      • Ljubomir Djordjevich, Anthony D. Ivankovich

      Pages 171-197

   4. Some Structural and Functional Properties of Hemoglobin-Containing Liposomes (Hemosomes), A Potential Red Blood Cell Substitute

      • J. Szebeni, E. E. Di Iorio, H. Hauser, K. H. Winterhalter

      Pages 199-208

   5. Liposome-Based Immunoassays for Detection of Small and Large Molecules

      • Bruce P. Gaber, Frances S. Ligler, Reinhard Bredehorst

      Pages 209-214

5. Artificial Cells

   1. Artificial Cells with Ultrathin Lipid-Polymer or Lipid-Protein Membranes

      • T. M. S. Chang

      Pages 215-223

   2. Immobilized Photosynthetic Membranes and Cells for the Production of Fuels and Chemicals

      • David O. Hall, K. Krishna Rao

      Pages 225-245

   3. Development of Plastid Membranes in Immobilized Systems

      • Christer Sundqvist, Cecilia Grevby

      Pages 247-256

In the twenty years since Bangham first described the model membrane system which he named "liposomes", a generation of scientists have explored the properties of lipid-based microstructures. Liposomes of all sizes, tubular and helical structures, and self-assembled lipid films have been prepared and studied in detail. Many of the advances· in the basic research have led to significant technological applications. Lipid microstructure research has begun to mature and it is an appropriate time for an in-depth look at the biotechnological applications, both achieved and potential. As a forum for active discussions within this growipg field, two Workshops were organized: "Technological Applications of Phospholipid Bilayers, Vesicles and Thin Films", held in Puerto de la Cruz, Tenerife, Canary Islands; and "Biotechnological Applications of Membrane Studies", held in Donostia-San Sabastian, Basque Country, Spain. The organizers of these Workshops believe that development of lipid self-assembly into a technological discipline requires significant interaction across traditional scientific boundaries. Thus the Workshops gathered an eclectic group of colleagues whose interests ranged from basic research into structure, interactions and stabilization of biomembranes to applications of lipid microstructures such as artificial cells, diagnostic reagents, energy transfer systems, and biosensors.

• Coenzym
• Lipid
• bacteria
• biomolecule
• biosensor
• biosensors
• cells
• development
• energy
• enzymes
• liposomes
• protein
• structure
• system
• thin films

• Naval Research Laboratory, USA

  Bruce Paul Gaber, Joel M. Schnur

• Royal Free Hospital School of Medicine, London, UK

  Dennis Chapman

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