Physical and Chemical Mechanisms in Molecular Radiation Biology

1. Front Matter

   Pages i-x

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2. Introduction to the Problem

   1. Front Matter

      Pages 1-1

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   2. The Molecular Biology of Radiation Carcinogenesis

      • Eric J. Hall, Greg A. Freyer

      Pages 3-25

3. Radiological Physics

   1. Front Matter

      Pages 27-27

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   2. Atomic and Molecular Theory

      • Mitio Inokuti

      Pages 29-50

   3. Atomic and Molecular Physics in the Gas Phase

      • L. H. Toburen

      Pages 51-97

   4. Radiation Interactions and Energy Transport in the Condensed Phase

      • R. H. Ritchie, R. N. Hamm, J. E. Turner, H. A. Wright, W. E. Bolch

      Pages 99-135

   5. Charged-Particle Transport in the Condensed Phase

      • Marco Zaider

      Pages 137-162

   6. Radial Distribution of Dose

      • Robert Katz, Matesh N. Varma

      Pages 163-180

4. Early Chemical Events

   1. Front Matter

      Pages 181-181

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   2. Radiation Interactions in High-Pressure Gases

      • Loucas G. Christophorou

      Pages 183-230

   3. Energy Transfer, Charge Transfer, and Proton Transfer in Molecular Composite Systems

      • Michael Kasha

      Pages 231-255

   4. Early Chemical Events and Initial DNA Damage

      • Aloke Chatterjee, William R. Holley

      Pages 257-285

   5. The Chemistry of Free-Radical-Mediated DNA Damage

      • Clemens von Sonntag

      Pages 287-321

5. Models of Radiation Effects

   1. Front Matter

      Pages 323-323

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   2. The Radiobiological Significance of Spatial and Temporal Distribution of Energy Absorbed from Ionizing Radiations

      • Harald H. Rossi

      Pages 325-337

   3. Phenomenological Models

      • L. A. Braby

      Pages 339-365

   4. Mechanistic Models

      • Stanley B. Curtis

      Pages 367-386

   5. Carcinogenesis Models: An Overview

      • Suresh H. Moolgavkar

      Pages 387-399

6. Molecular Radiation Biology

   1. Front Matter

      Pages 401-401

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The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru­ mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.

• DNA
• biological effects
• biological materials
• high-pressure
• ionizing
• microscopy
• molecular biology

• Pacific Northwest Laboratories, Richland, USA

  William A. Glass

• U.S. Department of Energy, Germantown, USA

  Matesh N. Varma

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