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Research in Congenital Hypothyroidism

  • Book
  • © 1989

Overview

Editors:
  1. François Delange

    1. University of Brussels, Brussels, Belgium

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  2. Delbert A. Fisher

    1. Harbor-UCLA Medical Center, University of California, Los Angeles, Torrance, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Daniel Glinoer

    1. University of Brussels, Brussels, Belgium

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Part of the book series: NATO Science Series A: (NSSA)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xi
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  2. Physiopathology

    1. Front Matter

      Pages 1-1
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    2. Placental Transfer of Substances from Mother to Fetus Affecting Fetal Pituitary-Thyroid Function

      • Lewis E. Braverman
      Pages 3-14

    3. Transfer of Thyroid Hormones from the Mother to the Fetus

      • Gabriella Morreale de Escobar, María Jesús Obregón, Francisco Escobar del Rey
      Pages 15-29

    4. Role of the Placenta in Fetal Thyroid Homeostasis

      • Charles H. Emerson
      Pages 31-43

    5. Role of the Maternal Carrier Proteins in the Supply of Thyroid Hormones to the Feto-Placental Unit: Evidence of a Feto-Placental Requirement for Thyroxine

      • Roger Ekins, Arun Sinha, Maria Ballabio, Mark Pickard, Michael Hubank, Zaidan al Mazidi et al.
      Pages 45-60

    6. Maturation of Thyroid Hormone Actions

      • Delbert A. Fisher, Daniel H. Polk
      Pages 61-77

    7. Regulation of Intracellular Thyroid Hormone Concentrations in the Fetus

      • Maria Jesús Obregón, Carmen Ruiz de Oña, Francisco Escobar del Rey, Gabriella Morreale de Escobar
      Pages 79-94

    8. Action of Thyroid Hormones on Brain Development

      • Jean H. Dussault
      Pages 95-102

  3. Etiology

    1. Front Matter

      Pages 109-109
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    2. Transient Hypothyroidism in Infants due to Maternal TSH-Receptor Blocking Antibodies-Character of Their IgG and Long-Term Prognosis of Their Infants

      • Nobuo Matsuura, Junji Konishi, Kenji Fujieda, Kenji Yuri, Shohei Harada, Kanji Kasagi et al.
      Pages 111-122

    3. Sporadic and Endemic Congenital Hypothyroidism: Evidence for Autosensitization

      • Steven C. Boyages, Jan Willem Lens, Reindert D. van der Gaag, Glen F. Maberly, Creswell J. Eastman, Hemmo A. Drexhage
      Pages 123-133

    4. Thyroid Growth Blocking Antibodies and Congenital Hypothyroidism

      • Jean H. Dussault
      Pages 135-140

    5. TSH-Blocking Antibodies and Congenital Hypothyroidism

      • Luca Chiovato, Paolo Vitti, Claudio Marcocci, Gianfranco Fenzi, Lia Giusti, Ferruccio Santini et al.
      Pages 141-150

  4. Diagnosis

    1. Front Matter

      Pages 155-155
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    2. Congenital Defects Associated with Congenital Hypothyroidism

      • John Lazarus, Ieuan Hughes, Peter Harper, Stephen Bamforth
      Pages 157-164

    3. Resistance to Thyroid Hormones and Screening for High Thyroxine at Birth

      • Samuel Refetoff, Myriam Charbonneau, David H. Sarne, Junta Takamatsu, Jean H. Dussault
      Pages 165-172

    4. Iodine Nutrition and Congenital Hypothyroidism

      • François Delange
      Pages 173-185

    5. Scintigraphy in Congenital Hypothyroidism

      • A. M. Ermans, J. Verelst, J. P. Chanoine, F. Delange
      Pages 187-192

    6. Cervical Ultrasound in Congenital Hypothyroidism

      • M. Hassan, C. Garel, J. Leger, P. Czenichov
      Pages 193-198
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Keywords

About this book

Systematic screening for congenital hypothyroidism in the newborn was introduced some 15 years ago. The main objective was the prevention of mental retardation due to thyroid hormone deficiency during the early months of life. During the past decade screening programs have become routine throughout most of the industrialized world and many questions relating to implementation, organization and quality control of such programs have been largely resolved. Preliminary IQ and neurological data have indicated that screening and early treatment do, in fact, prevent mental retardation. However, a number of scientific questions related to congenital hypothyroidism remain unanswered and extensive research activities are ongoing in the field. The objective of the organizers of the Brussels workshop was to focus almost exclusively on these current research aspects of the screening programs. This workshop is the third international conference specifically devoted to neonatal thyroid screening. The first was held in La Malbaie in Quebec in the fall of 1979. That meeting was well organized and highly productive. Its proceedings constitute a bible in the field. After the Quebec meeting, we witnessed major and rapid advances in our understanding of neonatal thyroid physiology as well as screening methodology, organiza­ tion, data management, the significance of an approach to false negative and false positive results,patient follow-up, and assessment of follow-up and treatment, and the psychoneurological evaluation of affected infants. Some of these aspects were further developed during a second highly pro­ ductive international conference organized in Tokyo in 1982.

Editors and Affiliations

  • University of Brussels, Brussels, Belgium

    François Delange, Daniel Glinoer

  • Harbor-UCLA Medical Center, University of California, Los Angeles, Torrance, USA

    Delbert A. Fisher

Bibliographic Information

  • Book Title: Research in Congenital Hypothyroidism

  • Editors: François Delange, Delbert A. Fisher, Daniel Glinoer

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-7580-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1989

  • Softcover ISBN: 978-1-4684-7582-1Published: 10 May 2012

  • eBook ISBN: 978-1-4684-7580-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 367

  • Number of Illustrations: 126 b/w illustrations

  • Topics: Human Physiology, Pathology

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