The Biology of Glycoproteins

1. Front Matter

   Pages i-xiv

   PDF

2. Integral Membrane Glycoproteins in Cell-Cell and Cell-Substratum Adhesion

   • Caroline H. Damsky, Karen A. Knudsen, Clayton A. Buck

   Pages 1-64

3. Attachment Proteins and Their Role in Extracellular Matrices

   • A. Tyl Hewitt, George R. Martin

   Pages 65-93

4. Role of Glycoproteins during Early Mammalian Embryogenesis

   • Raymond J. Ivatt

   Pages 95-181

5. Cell Surface Glycoproteins and Carbohydrate Antigens in Development and Differentiation of Human Erythroid Cells

   • Minoru Fukuda, Michiko N. Fukuda

   Pages 183-234

6. Carbohydrate Structure, Biological Recognition, and Immune Function

   • Christopher L. Reading

   Pages 235-321

7. Nervous System Glycoproteins

   • Paul T. Kelly

   Pages 323-369

8. The Role of Glycoproteins in the Life Cycle of the Cellular Slime Mold Dictyostelium discoideum

   • Ellen J. Henderson

   Pages 371-443

9. Back Matter

   Pages 445-449

   PDF

This book is in many ways a sequel to The Biochemistry ojGlycoproteins and Proteoglycans. The enormous recent progress in understanding the biological roles of glycoproteins has prompted the present volume. The reasons for studying glycoproteins have multiplied, and in the present volume the roles played by glycoproteins are explored in a variety of biological situations. The first two chapters describe molecules involved in cell-substratum and cell-cell interactions in a broad sense, and also focus on recent progress in identifying specific attachment molecules. Our understanding of how normal processes, such as cellular differentiation and tissue organization, are regulated is dependent on understanding how cells interact with the extracellular matrix. When these processes go awry the consequences can be tragic, for example, when manifest as birth de­ fects and cancer. Our ability to devise appropriate therapies is in many cases limited by our understanding of such cell-matrix interactions. The third chapter explores the roles by glycoproteins during early mammalian development. The carbohydrate portions c1early play very important roles in presenting information during early embryogenesis, and an unusual tumor stern cell, the embryonal carcinoma, looks very promising in pro­ viding an experimental system for understanding how the expression of these complex carbohydrate determinants is regulated. The next three chapters explore the biology of glycoproteins in distinct situations: in the immune system, in the nervous system, and during erythropoiesis.

• biology
• brain
• carcinoma
• cell
• cells
• cellular differentiation
• chemistry
• embryo
• immune system
• molecule
• nervous system
• organizations
• proteins
• tissue
• tumor

• M. D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, USA

  Raymond J. Ivatt

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