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Lymphocyte Stimulation

Differential Sensitivity to Radiation Biochemical and Immunological Processes

  • Book
  • © 1980

Overview

Editors:
  1. Amleto Castellani

    1. Division of Radiation Protection, CNEN - CSN Casaccia, Rome, Italy

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Lymphocyte Stimulation by Nonspecific Mitogens

    • Bilha Schechter
    Pages 1-13

  3. DNA Replication Units in Eukaryotes

    • Francesco Amaldi
    Pages 15-32

  4. Functions of DNA Polymerases α, β and γ in DNA Replication and Repair

    • Miria Stefanini, Anna I. Scovassi, Umberto Bertazzoni
    Pages 33-51

  5. DNA Synthesis and DNA Polymerases in Tonsillar Lymphocytes

    • F. Antoni, Maria Staub
    Pages 53-72

  6. The Effect of UV Light on the Human Lymphocytes

    • F. Antoni, I. Csuka, I. Vincze, Gy. Farkas, M. Staub
    Pages 73-83

  7. Radiation Sensitivity of Stimulated Human Lymphocytes: Relation to DNA Repair and Cell Membrane Activation Processes

    • A. Castellani, C. Catena, G. Biondi
    Pages 85-96

  8. Screening for Deficits in DNA Repair Using Human Lymphocytes

    • Shyam S. Agarwal, Lawrence A. Loeb
    Pages 97-107

  9. DNA Repair in Some Cancer-Prone Conditions and in Patients with Cutaneous Malignancies

    • Bo Lambert, Ulrik Ringborg
    Pages 109-118

  10. Sister Chromatid Exchange in Human Lymphocytes as an Indicator of DNA Damage and Repair in Vivo

    • Bo Lambert
    Pages 119-130

  11. Far and Near Ultraviolet Light as Molecular Probes for Assessment of DNA Repair and Radiosensitivity

    • Emanuel Riklis
    Pages 131-137

  12. Enzymes from Calf Thymus That Might Be Involved in DNA Repair

    • Francesco Campagnari
    Pages 139-159

  13. Immunoregulatory T Cell Subpopulations in Man

    • M. C. Mingari, A. Moretta, W. G. Canonica, M. Colombatti, L. Moretta
    Pages 161-166

  14. Thymocyte Maturation Induced by a Cyclic AMP-Elevating Thymic Factor

    • A. Astaldi, G. C. B. Astaldi
    Pages 167-175

  15. Receptors and Cell Collaboration in the Immune System

    • Klaus Rajewsky
    Pages 177-182

  16. Back Matter

    Pages 183-188
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Keywords

About this book

This book is a collection of some of the papers presented at the EMBO Lecture Course on "Lymphocyte stimulation: differential sensitivity to radiation; biochemical and immunological properties." The Course was organized with the aim of fostering interactions between photoradiobiologists and immunologists interested in the problem of DNA damage and repair studied at the lymphocyte level. The papers presented in this book are mainly centered on the problem of radiation sensitivity of lymphocytes in relation to DNA repair phenomena. The radiation biology of human lymphocytes is dominated by two phenomena: (a) high radiosensitivity of lymphocytes which die in interphase (b) PHA-induced relative radioresistance of those cells which, after stimulation, escape the interphase death and eventually die in mitosis. These phenomena constitute a good system to study some of the factors which control the response of human cells to irradiation. In addition it is possible to correlate the development of the relative radioresistance in PHA-stimulated lymphocytes with the biochemical changes connected with the transformation processes. The papers presented in this book constitute a real contribution to the scientific knowledge in this field of research and suggest that lymphocytes could be a very interesting test material useful for measuring the DNA repair capability of human cells to furnish an indication of individual radiosensitivity in man.

Editors and Affiliations

  • Division of Radiation Protection, CNEN - CSN Casaccia, Rome, Italy

    Amleto Castellani

Bibliographic Information

  • Book Title: Lymphocyte Stimulation

  • Book Subtitle: Differential Sensitivity to Radiation Biochemical and Immunological Processes

  • Editors: Amleto Castellani

  • DOI: https://doi.org/10.1007/978-1-4684-6997-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1980

  • Softcover ISBN: 978-1-4684-6999-8Published: 21 July 2012

  • eBook ISBN: 978-1-4684-6997-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 188

  • Number of Illustrations: 7 b/w illustrations

  • Topics: Anatomy

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