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Generalized Epilepsy

Neurobiological Approaches

  • Book
  • © 1990

Overview

Editors:
  1. Massimo Avoli

    1. Montreal Neurological Institute, Department of Neurophysiology, McGill University, Montreal, Canada

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  2. Pierre Gloor

    1. Montreal Neurological Institute, Department of Neurophysiology, McGill University, Montreal, Canada

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  3. George Kostopoulos

    1. Department of Physiology, University of Patras Medical School, Patras, Greece

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  4. Robert Naquet

    1. Laboratoire de Physiologie Nerveuse, CNRS, Gif-sur-Yvette, France

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xv
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  2. Historical Introduction

    1. Historical Introduction

      • H. H. Jasper
      Pages 1-15

  3. Clinical Background

    1. Front Matter

      Pages 17-17
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    2. The Syndromes of Generalized Epilepsy

      • F. E. Dreifuss
      Pages 19-29

    3. Unanswered Clinical Questions in Generalized Epilepsy

      • F. Andermann
      Pages 30-35

    4. The Relationship Between Sleep Spindles and Spike-and-Wave Bursts in Human Epilepsy

      • P. Kellaway, J. D. Frost Jr., J. W. Crawley
      Pages 36-48

  4. Fundamental Cellular and Neurotransmitter Mechanisms

    1. Front Matter

      Pages 49-49
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    2. Membrane Properties of Cat Betz Cells Studied In Vitro

      • W. E. Crill, P. C. Schwindt, W. J. Spain
      Pages 51-60

    3. Changes in Extracellular Ions Associated with Epileptiform Discharges

      • R. Pumain, U. Heinemann
      Pages 61-85

    4. Role of Neurotransmitters in the Genesis of Epileptiform Discharges

      • K. Krnjević
      Pages 86-101

    5. Excitant Amino Acids in Epilepsy

      • C. L. Faingold, B. S. Meldrum
      Pages 102-117

    6. Possible Epileptogenic Consequences of Misused GABAergic Relationships

      • J. Champagnat, C. Silva-Barrat, S. Brailowsky, Ch. Menini
      Pages 118-125

    7. Anticonvulsant Effects of Intracortical Chronic Infusion of GABA in Generalized Epilepsy

      • S. Brailowsky, C. Silva-Barrat, Ch. Ménini, D. Riche, R. Naquet
      Pages 126-136

    8. In Vitro Electrophysiology of a Genetic Model of Generalized Epilepsy

      • G. Kostopoulos, C. Psarropoulou
      Pages 137-157

  5. Thalamic and Cortical Mechanisms in Absence Attacks

    1. Front Matter

      Pages 159-159
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    2. Spindling, Incremental Thalamocortical Responses, and Spike-Wave Epilepsy

      • M. Steriade
      Pages 161-180

    3. Physiology of Thalamic Relay Neurons: Properties of Calcium Currents Involved in Burst-Firing

      • J. R. Huguenard, D. A. Coulter, D. A. Prince
      Pages 181-189

    4. Thalamocortical Relationships in Generalized Epilepsy with Bilaterally Synchronous Spike-and-Wave Discharge

      • P. Gloor, M. Avoli, G. Kostopoulos
      Pages 190-212

    5. Focal and Generalized Epileptiform Activity in the Cortex: In Search of Differences in Synaptic Mechanisms, Ionic Movements, and Long-Lasting Changes in Neuronal Excitability

      • M. Avoli, P. Gloor, G. Kostopoulos
      Pages 213-231

    6. Pharmacology of the Inhibitory Systems in Primary Generalized Epilepsy of “Petit Mal” Type

      • R. G. Fariello
      Pages 232-237
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Keywords

About this book

In recent years there has been intense interest in the basic mechanisms of epilepsy. Many symposia and monographs have been devoted to this topic. These reviews, however, have focused almost exclusively on studies performed in models of partial (or focal) epilepsy. It was natural that scientists interested in the fundamental mechanism of epileptogenesis at the cellular level were attracted to work on models in which the epileptogenic dysfunction could be confined to ever-smaller populations of neurons. Many of the most illuminating studies done in this field in the recent past have been carried out in vitro on brain slices or on dissociated neuronal cultures. Much valuable insight into the mechanisms of epileptogenesis has been obtained in this manner. One cannot, however, automatically assume that mechanisms elucidated in such exquisitely "focal" models are applicable to forms of epilepsy in which seizures from their very start involve the entire brain. One of the most difficult questions that arises in this context is how epileptogenic dysfunction, which can be understood in terms of mechanisms involving a few contiguous cells, can lead to what appears to be a simultaneous onset of seizure discharge in virtually all areas of the brain. Most of the workers who have made excellent contributions to the understanding of the cellular mechanisms involved in epileptogenesis have paid virtually no attention to this important problem.

Editors and Affiliations

  • Montreal Neurological Institute, Department of Neurophysiology, McGill University, Montreal, Canada

    Massimo Avoli, Pierre Gloor

  • Department of Physiology, University of Patras Medical School, Patras, Greece

    George Kostopoulos

  • Laboratoire de Physiologie Nerveuse, CNRS, Gif-sur-Yvette, France

    Robert Naquet

Bibliographic Information

  • Book Title: Generalized Epilepsy

  • Book Subtitle: Neurobiological Approaches

  • Editors: Massimo Avoli, Pierre Gloor, George Kostopoulos, Robert Naquet

  • DOI: https://doi.org/10.1007/978-1-4684-6767-3

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Boston, Inc. 1990

  • Softcover ISBN: 978-1-4684-6769-7Published: 26 March 2012

  • eBook ISBN: 978-1-4684-6767-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 482

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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