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Animal Models of Depression

  • Book
  • © 1989

Overview

Editors:
  1. George F. Koob

    1. Department of Neuropharmacology, Research Institute of the Scripps Clinic, La Jolla, USA

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  2. Cindy L. Ehlers

    1. Department of Neuropharmacology, Research Institute of the Scripps Clinic, La Jolla, USA

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  3. David J. Kupfer

    1. Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, USA

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiii
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  3. Developmental Models

    1. Front Matter

      Pages 55-55
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    2. The HPA System and Neuroendocrine Models of Depression

      • Ned H. Kalin
      Pages 57-73

    3. The Use of an Animal Model to Study Post-Stroke Depression

      • Robert G. Robinson
      Pages 74-98

    4. Social Zeitgebers: A Peer Separation Model of Depression in Rats

      • Cindy L. Ehlers, Tamara L. Wall, Stephan P. Wyss, R. Ian Chaplin
      Pages 99-110

    5. Electrophysiology of the Locus Coeruleus: Implications for Stress-Induced Depression

      • Jay M. Weiss, Peter E. Simson
      Pages 111-134

    6. Motor Activity and Antidepressant Drugs: A Proposed Approach to Categorizing Depression Syndromes and Their Animal Models

      • Martin H. Teicher, Natacha I. Barber, Janet M. Lawrence, Ross J. Baldessarini
      Pages 135-161

    7. Anhedonia as an Animal Model of Depression

      • George F. Koob
      Pages 162-183

  4. Pharmacologic Models

    1. Front Matter

      Pages 185-185
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    2. Models of Depression Used in the Pharmaceutical Industry

      • James L. Howard, Robert M. Ferris, Barrett R. Cooper, Francis E. Soroko, Ching M. Wang, Gerald T. Pollard
      Pages 187-203

    3. Pharmacological, Biochemical, and Behavioral Analyses of Depression: Animal Models

      • Robert M. Zacharko, Hymie Anisman
      Pages 204-238

    4. Pharmacological Probes in Primate Social Behavior

      • R. Francis Schlemmer Jr., Jennifer E. Young, John M. Davis
      Pages 239-260

    5. The Neuropharmacology of Serotonin and Sleep: an Evaluation

      • John D. Fernstrom, Ross H. Pastel
      Pages 261-280

    6. Epilogue

      • Floyd E. Bloom
      Pages 281-284

  5. Back Matter

    Pages 285-295
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Keywords

About this book

Animal models represent experimental investigations developed in one species for the purpose of studying phenomena in another species and provide numerous advantages for preclinical research. They allow scientists greater control and isolation of important experimental variables. Animal models are safe, reproducible strategies by which to evaluate and design new pharma­ cological treatment strategies, while also allowing direct central nervous system intervention to alter the course of the aberrant behavior. Animal models have been developed for a number of mental illnesses; in this particular domain, they hold the promise to shed light on the still obscure etiologies of these illnesses and ultimately to facilitate the development and testing of "cures. " Yet, true models of mental illness are difficult to develop, because mental illness may be a uniquely human phenomenon. It was based on these considerations that the MacArthur Foundation Research Network on the Psychobiology of Depression set out to sponsor a conference to review the status, problems, promises, and relevance of animal models to the clinical conditions of affective disorders. The conference was held in September 1986 and included participants from both within the Network as well as scientists and scholars from various disciplines relevant to the concerns of the conference. After the conference was held, it became clear to the organizers that the material presented could be helpful to a broader field of investigators, since a significant portion of the information has not been presented elsewhere or in the unified context of a monograph.

Editors and Affiliations

  • Department of Neuropharmacology, Research Institute of the Scripps Clinic, La Jolla, USA

    George F. Koob, Cindy L. Ehlers

  • Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, USA

    David J. Kupfer

Bibliographic Information

  • Book Title: Animal Models of Depression

  • Editors: George F. Koob, Cindy L. Ehlers, David J. Kupfer

  • DOI: https://doi.org/10.1007/978-1-4684-6762-8

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Boston 1989

  • Softcover ISBN: 978-1-4684-6764-2Published: 13 March 2012

  • eBook ISBN: 978-1-4684-6762-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 298

  • Topics: Medicine/Public Health, general, Popular Science in Psychology, Life Sciences, general

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