Skip to main content
SpringerLink
Log in

MHC Molecules: Expression, Assembly and Function

  • Book
  • © 1996

Overview

Authors:
  1. Robert G. Urban

    1. Harvard University, Cambridge, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

  2. Roman M. Chicz

    1. Harvard University, Cambridge, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 16.99 USD 59.99
Discount applied Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Major Histocompatibility Antigens: An Introduction

    • Roman M. Chicz, Robert G. Urban
    Pages 1-8

  3. The Major Histocompatibility Complex Genes and their Transcriptional Regulation

    • Sarki A. Abdulkadir, Vincenzo Casolaro, Lisa S. Schwiebert, Zhimin Song, Santa Jeremy Ono
    Pages 9-34

  4. TAP Peptide Transporters and Antigen Presentation

    • Frank Momburg, Günter J. Hämmerling, Jacques J. Neefjes
    Pages 35-63

  5. Molecular Chaperones in MHC Class I and Class II Biosynthesis and Assembly

    • Sumati Rajagopalan
    Pages 65-71

  6. Polypeptide Release from Lysosomes

    • Lois Isenman
    Pages 73-82

  7. Intracellular Trafficking of MHC Class II Molecules

    • Alexander Y. Rudensky
    Pages 83-96

  8. The Role of HLA-DM in Class II Antigen Presentation

    • Tom Cotner, Donald Pious
    Pages 97-111

  9. Crystallographic Analysis of Peptide Binding by Class I and Class II Major Histocompatibility Antigens

    • Edward J. Collins
    Pages 113-134

  10. HLA and Disease: Molecular Basis

    • Joan C. Gorga, Dimitri Monos
    Pages 135-162

  11. Epitope Prediction Algorithms for Class I MHC Molecules

    • Kenneth C. Parker
    Pages 163-180

  12. Options for TCR Interactions: TCR Agonists, Antagonists and Partial Agonists

    • Stephen C. Jameson, Kristin A. Hogquist
    Pages 181-190

  13. Role of Ligand Density in T Cell Reactions

    • Theodore J. Tsomides
    Pages 191-206

  14. Cooperative Recognition of MHC Class II:Peptide Complexes by the T Cell Receptor and CD4

    • Dario A. A. Vignali
    Pages 207-228

  15. Receptors for MHC Class I Molecules in Human Natural Killer Cells

    • Marco Colonna
    Pages 229-241

  16. The MHC in Host-Pathogen Evolution

    • Miles P. Davenport, Adrian V. S. Hill
    Pages 243-260

  17. Peptide-Mediated Regulation of Allergic Diseases

    • Charlotte Hetzel, Gerard F. Hoyne, Nanna M. Kristensen, Timothy Bourne, Daphne Tsitoura, Jonathan R. Lamb
    Pages 261-279

  18. Genetic Modulation of Antigen Presentation

    • Mary Lynne Hedley
    Pages 281-294

  19. Back Matter

    Pages 295-298
    Download chapter PDF
Back to top

Keywords

About this book

3 nant expression systems have been used to make MHC molecules con­ taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesized. Briefly, the entire sequence of the tar­ get protein is chemically synthesized using overlapping peptides which are then screened for biological activity using standard T cell presen­ tation assays. Despite its limitations, this method was used to identify the first immunodominant epitopes reported in the literature and con­ tinues to be used successfully today.

Authors and Affiliations

  • Harvard University, Cambridge, USA

    Robert G. Urban, Roman M. Chicz

Bibliographic Information

  • Book Title: MHC Molecules: Expression, Assembly and Function

  • Authors: Robert G. Urban, Roman M. Chicz

  • DOI: https://doi.org/10.1007/978-1-4684-6462-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: R.G. Landes Company and Chapman & Hall 1996

  • eBook ISBN: 978-1-4684-6462-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Illustrations: 52 b/w illustrations, 37 illustrations in colour

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

Publish with us

Policies and ethics

Back to top

Search

Navigation