Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Structure and Function of the Aspartic Proteinases

Genetics, Structures, and Mechanisms

  • Book
  • © 1991

Overview

Editors:
  1. Ben M. Dunn

    1. University of Florida-College of Medicine, Gainesville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 306)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (77 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Mammalian Gastric Proteinases: Plenary Lectures

    1. Studies on Pepsin Mutagenesis and Recombinant Rhizopuspepsinogen

      • X. L. Lin, M. Fusek, Z. Chen, G. Koelsch, H. P. Han, J. A. Hartsuck et al.
      Pages 1-8

    2. Inhibitor Binding Induces Structural Changes in Porcine Pepsin

      • Cele Abad-Zapatero, T. J. Rydel, D. J. Neidhart, J. Luly, J. W. Erickson
      Pages 9-21

    3. Functional Implications of the Three-Dimensional Structure of Bovine Chymosin

      • Gary L. Gilliland, Maureen Toner Oliva, Jonathan Dill
      Pages 23-37

    4. Why Does Pepsin Have a Negative Charge at Very Low pH? An Analysis of Conserved Charged Residues in Aspartic Proteinases

      • Natalia S. Andreeva, Michael N. G. James
      Pages 39-45

    5. X-Ray Structural Studies of Mammalian Aspartic Proteinases

      • J. B. Cooper, M. P. Newman
      Pages 47-61

    6. Aspartic Protease Inhibitors from the Parasitic Nematode Ascaris

      • Mark R. Martzen, Brad A. McMullen, Kazuo Fujikawa, Robert J. Peanasky
      Pages 63-73

    7. Nonspecific Electrostatic Binding of Substrates and Inhibitors to Porcine Pepsin

      • Petr Kuzmič, Chong-Qing Sun, Zhi-Cheng Zhao, Daniel H. Rich
      Pages 75-86

  3. Mammalian Gastric Proteinases: Poster Reports

    1. Analysis of the Promoter of a Human Pepsinogen a Gene

      • P. H. S. Meijerink, J. P. Bebelman, G. Pals, F. Arwert, R. J. Planta, A. W. Eriksson et al.
      Pages 87-90

    2. Separation and Characterization of Human Pepsinogens and Pepsins by High-Resolution Discontinuous Electrophoresis

      • W. Wnuk, E. Loizeau
      Pages 91-94

    3. A Highly Informative Polymorphism of the Pepsinogen C Gene Detected by Polymerase Chain Reaction

      • R. Thomas Taggart, Takeshi Azuma, S. Wu, Graeme I. Bell, Anne M. Bowcock
      Pages 95-99

    4. Consequences of Intramolecular Ionic Interactions for the Activation Rate of Human Pepsinogens A and C as Revealed by Molecular Modelling

      • Ruud A. Bank, Robert B. Russell, Gerard Pals, Michael N. G. James
      Pages 101-105

    5. Characteristics and Composition of Pepsins from Atlantic Cod

      • Asbjorn Gildberg, Ragnar L. Olsen, Jon B. Bjarnason
      Pages 107-110

    6. Reduction of Non-Steroidal Anti-Inflammatory Drug Induced Gastric Damage in the Rat by Soluble Pepstatin Derivatives

      • C. J. Grinham, C. J. Campbell, C. E. Barker, A. Baxter
      Pages 111-113

    7. Production of Prochymosin in Lactococci

      • Guus Simons, Ger Rutten, Miranda Hornes, Monique Nijhuis, Martien van Asseldonk
      Pages 115-119

    8. Structure and Chromosomal Localization of the Human Prochymosin Pseudogene

      • Tönis Örd, Meelis Kolmer, Juhani Jänne, Richard Villems, Mart Saarma
      Pages 121-126

    9. Amino Acid Sequence of Lamb Preprochymosin and its Comparison to Other Chymosins

      • Jože Pungerčar, Borut Štrukelj, Franc Gubenšek, Vito Turk, Igor Kregar
      Pages 127-131

    10. Quantum-Chemical Study of the Catalytic Mechanism of Aspartic Proteinases

      • V. K. Antonov, S. L. Alexandrov
      Pages 133-137

    11. Effects of Viscosity and Solvent Deuterium Identify Multiple Partially Rate-Limiting Steps in the Kinetics of Porcine Pepsin

      • Karen L. Rebholz, Dexter B. Northrop
      Pages 139-142

    12. Structure-Function Database for Active Site Binding to the Aspartic Proteinases

      • Chetana Rao, Paula E. Scarborough, W. Todd Lowther, John Kay, Brian Batley, Stephen Rapundalo et al.
      Pages 143-147
Back to top

Keywords

About this book

In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.

Editors and Affiliations

  • University of Florida-College of Medicine, Gainesville, USA

    Ben M. Dunn

Bibliographic Information

  • Book Title: Structure and Function of the Aspartic Proteinases

  • Book Subtitle: Genetics, Structures, and Mechanisms

  • Editors: Ben M. Dunn

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-6012-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Softcover ISBN: 978-1-4684-6014-8Published: 29 March 2012

  • eBook ISBN: 978-1-4684-6012-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 608

  • Topics: Biochemistry, general, Human Genetics, Animal Anatomy / Morphology / Histology, Plant Sciences

Publish with us

Policies and ethics

Back to top

Search

Navigation