Chemotactic Cytokines

1. Front Matter

   Pages i-xiii

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2. Granulocyte and Monocyte Chemotactic Factors: Stimuli and Producer Cells

   • Jo Van Damme

   Pages 1-9

3. Activation of Human Neutrophils by NAP-1 and Other Chemotactic Agonists

   • Marco Baggiolini, Beatrice Dewald, Alfred Walz

   Pages 11-21

4. Induction and Regulation of Interleukin-8 Gene Expression

   • Robert M. Strieter, Theodore Standiford, Stephen W. Chensue, Keita Kasahara, Steven L. Kunkel

   Pages 23-30

5. Regulation of Human Interleukin 8 Gene Expression and Binding of Several Other Members of the Intercrine Family to Receptors for Interleukin-8

   • Naofumi Mukaida, Atsushi Hishinuma, Claus O. C. Zachariae, Joost J. Oppenheim, Kouji Matsushima

   Pages 31-38

6. Formation and Biological Properties of Neutrophil Activating Peptide 2 (NAP-2)

   • Alfred Walz, Roland Zwahlen, Marco Baggiolini

   Pages 39-46

7. Human Monocyte Chemoattractant Protein-1 (MCP-1)

   • Teizo Yoshimura, Edward J. Leonard

   Pages 47-56

8. Biological Aspects of Monocyte Chemoattractant Protein-1 (MCP-1)

   • Edward J. Leonard, Alison Skeel, Teizo Yoshimura

   Pages 57-64

9. Stimulus Specific Induction of Monocyte Chemotactic Protein-1 (MCP-1) Gene Expression

   • Steven L. Kunkel, Theodore Standiford, Keita Kasahara, Robert M. Strieter

   Pages 65-71

10. GRO: A Novel Chemotactic Cytokine

    • Ruth Sager, Stephen Haskill, Anthony Anisowicz, Douglas Trask, Marilyn C. Pike

    Pages 73-77

11. PDGF and the Small Inducible Gene (SIG) Family: Roles in the Inflammatory Response

    • Rodney S. Kawahara, Zheng-Wen Deng, Thomas F. Deuel

    Pages 79-87

12. Human Neutrophil Granule Cationic Protein CAP37 is a Specific Macrophage Chemotaxin that Shares Homology with Inflammatory Proteinases

    • John G. Morgan, H. Anne Pereira, Teresa Sukiennicki, John K. Spitznagel, James W. Larrick

    Pages 89-96

13. Biochemical and Biological Characterization of NAP-1/ IL-8-Related Cytokines in Lesional Psoriatic Scale

    • Jens-M. Schröder

    Pages 97-107

14. Chemotactic Cytokines in Inflammatory Skin Disease

    • Richard Camp, Kevin Bacon, Nicholas Fincham, Kay Mistry, Janet Ross, Frances Lawlor et al.

    Pages 109-118

15. Interleukin-8 —A Mediator of Inflammatory Lung Disease?

    • Diana Smith, Lisa Burrows, John Westwick

    Pages 119-126

16. Some Aspects of NAP-1 Pathophysiology: Lung Damage Caused by a Blood-Borne Cytokine

    • Antal Rot

    Pages 127-135

17. Human Mesangial Cell-Derived Interleukin 8 and Interleukin 6: Modulation by an Interleukin 1 Receptor Antagonist

    • Zarin Brown, Lynette Fairbanks, Robert M. Strieter, Guy H. Neild, Steven L. Kunkel, John Westwick

    Pages 137-145

18. NAP-1/IL-8 in Rheumatoid Arthritis

    • Ivan J. D. Lindley, Miroslav Ceska, Peter Peichl

    Pages 147-156

19. Abstracts

    • J. G. Morgan, H. A. Pereira, T. Sukiennicki, J. K. Spitznagel, J. W. Larrick, D. R. Forsdyke et al.

    Pages 157-179

20. Back Matter

    Pages 181-186

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The existence of a new family of chemotactic cytokines was realised in 1987 following the isolation and structural determination by several groups of a peptide consisting of 72 amino acids which was a potent activator of neutrophils and a chemotactic agent for lymphocytes. The first symposium of this series was held at the Royal College of Surgeons of England in December 1988, entitled Novel Neutrophil Stimulating Peptides, and brought together the majority of the laboratories which had published in this area, see Immunology Today 10: 146-147(1989). Since the first symposium there has been a dramatic increase in our knowledge of the biology of this family of structurally related peptides. The Second International Symposium on Chemotactic Cytokines was held at the Royal College of Surgeons of England in June 1990. The aim of this symposium was to provide both a forum for discussion and to determine whether this knowledge can be utilised in the design of novel therapeutic strategies for the treatment of inflammatory disorders. Although the majority of studies have been concerned with the regulation of these peptides at the molecular and cellular level, there is now evidence to suggest that specific members of this superfamily have a role in the pathogenesis of a number of diverse diseases including arthritis, psoriasis, atherosclerosis, wound repair, inflammatory lung diseases and glomerulonephritis.

• Amino acid
• Calcium
• gene expression
• interferon
• pathophysiology
• physiology

• The University of Bath, Avon, UK

  J. Westwick

• Sandoz Research Institute, Vienna, Austria

  I. J. D. Lindley

• University of Michigan, Ann Arbor, USA

  S. L. Kunkel

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