Advances in Perinatal Thyroidology

1. Front Matter

   Pages i-x

   PDF

2. Session I

   1. Mechanism of Thyroid Hormone Action

      • Leslie J. DeGroot

      Pages 1-10

   2. Thyroid System Ontogeny in the Sheep: A Model for Precocial Mammalian Species

      • Delbert A. Fisher

      Pages 11-26

   3. Pathologic Studies of Fetal Thyroid Development

      • Douglas R. Shanklin

      Pages 27-46

   4. Thyroid Hormone Control of Brain and Motor Development: Molecular, Neuroanatomical, and Behavioral Studies

      • S. A. Stein, P. M. Adams, D. R. Shanklin, G. A. Mihailoff, M. B. Palnitkar

      Pages 47-105

   5. The Thyroidectomized Pregnant Rat — An Animal Model to Study Fetal Effects of Maternal Hypothyroidism

      • Susan P. Porterfield, Chester E. Hendrich

      Pages 107-132

3. Session II

   1. Maternal Thyroid Hormones during Pregnancy: Effects on the Fetus in Congenital Hypothyroidism and in Iodine Deficiency

      • Gabriella Morreale de Escobar, María Jesus Obregón, Rosa Calvo, Francisco Escobar del Rey

      Pages 133-156

   2. Thyroid Function and Hyperfunction in the Pregnant Woman

      • Gerard N. Burrow

      Pages 157-166

   3. Postpartum Thyroid Disease

      • Nobuyuki Amino

      Pages 167-180

4. Session III

   1. Transfer and Metabolism of Thyroid-Related Substances in the Placenta

      • Charles H. Emerson, Lewis E. Braverman

      Pages 181-196

   2. Regulation of Thyroid Function in Pregnancy: Maternal and Neonatal Repercussions

      • Daniel Glinoer

      Pages 197-201

   3. Congenital Hypothyroidism: New Insight Regarding Etiology

      • Jean H. Dussault

      Pages 203-208

   4. Maternally Transferred Thyroid Disease in the Infant: Recognition and Treatment

      • Thomas P. Foley Jr.

      Pages 209-226

   5. Thyroid Function in the Preterm Infant

      • Frank B. Diamond Jr., Allen W. Root

      Pages 227-241

   6. Use of TRH in the Fetus to Advance Lung Maturity

      • William F. O’Brien

      Pages 243-250

5. Session IV

   1. Diverse Abnormalities of the c-erbAβ Thyroid Hormone Receptor Gene in Generalized Thyroid Hormone Resistance

      • Stephen J. Usala, Barry B. Bercu, Samuel Refetoff

      Pages 251-258

6. Back Matter

   Pages 259-270

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Perinatal problems in thyroid gland physiology are common but complicated and present a diagnostic dilemma for the primary clinician. In December 1990, an international group of basic and clinical investigators gathered in Longboat Key, Florida to address these issues. The participants included internists, obstetricians, pedia­ tricians, neurologists, pathologists and basic scientists in cellular metabolism, endocrine physiology, and molecular biology. The presentations contained within this book bring together their most current and vital research related to the field of perinatal thyroidology. This book is based on the dynamic and fruitful exchange of the participants at the symposium. We are indebted to these individuals whose valuable insights and efforts are contained within this text. Barry B. Bercu Dorothy I. Shulman vii CONTENTS Session I Mechanism of Thyroid Hormone Action 1 Leslie J. DeGroot Thyroid System Ontogeny in the Sheep: A Model for Precocial Mammalian Species • . . • • 11 Delbert A. Fisher Pathologic Studies of Fetal Thyroid 27 Development • • • • • • • Douglas R. Shanklin Thyroid Hormone Control of Brain and Motor Development: Molecular, Neuroanatomical, 47 and Behavioral Studies • • • • • • • S. A. Stein, P. M. Adams, D. R. Shanklin, G. A. Mihailoff, and M. B. Palnitkar The Thyroidectomized Pregnant Rat: An Animal Model to Study Fetal Effects of Maternal Hypothyroidism 107 Susan P. Porterfield and Chester E.

• Internist
• genes
• hormone resistance
• metabolism
• ontogeny
• physiology
• thyroid hormone
• diabetes

• College of Medicine, University of South Florida, Tampa, USA

  Barry B. Bercu, Dorothy I. Shulman

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