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Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

  • Book
  • © 1991

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Editors:
  1. Mohan K. Raizada

    1. University of Florida, Gainesville, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Derek LeRoith

    1. National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 293)

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Table of contents (44 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Insulin-Like Growth Factors I and II

    1. Structural and Regulatory Aspects of the Human Genes Encoding IGF-I and -II

      • J. S. Sussenbach, P. H. Steenbergh, E. Jansen, P. Holthuizen, D. Meinsma, M. A. van Dijk et al.
      Pages 1-14

    2. Structural and Functional Characterization of IGF-I RNA 3’ Variants

      • P. Kay Lund, Eileen C. Hoyt, Judson J. Van Wyk
      Pages 15-21

    3. Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins

      • Margaret A. Cascieri, Gary G. Chicchi, Marvin L. Bayne
      Pages 23-30

    4. Insulin-Like Growth Factor II: Complexity of Biosynthesis and Receptor Binding

      • Steen Gammeltoft, Jan Christiansen, Finn C. Nielsen, Sten Verland
      Pages 31-44

    5. Development of a Specific Radioimmuno Assay for E Domain Containing Forms of Insulin-Like Growth Factor II

      • James F. Perdue, Linda K. Gowan, W. Robert Hudgins, Joan Scheuermann, Beverly Foster, Sharron Northcutt Brown
      Pages 45-56

    6. The Role of the IGFs in Myogenic Differentiation

      • K. A. Magri, D. Z. Ewton, J. R. Florini
      Pages 57-76

    7. Extinction of Human Insulin-Like Growth Factor II Expression in Somatic Cell Hybrids

      • Raffaele Zarrilli, Vittorio Colantuoni, Raffaella Faraonio, Stefano Casola, Elena Rossi, Carmelo B. Bruni
      Pages 77-83

    8. The Growth Hormone-Insulin-Like Growth Factor I Axis: Studies in Man during Growth

      • Thomas J. Merimee, Suzanne Quinn, Betty Russell, William Riley
      Pages 85-96

    9. Recombinant Human Insulin-Like Growth Factor I: Effects in Normal Subjects and Implications for Use in Patients

      • Hans-Peter Guler, Katharina Wettstein, Werner Schurr, Jurgen Zapf, E. Rudolf Froesch
      Pages 97-104

    10. Single sc Administration of Insulin-Like Growth Factor I (IGF-I) in Normal Men

      • Naomi Hizuka, Kazue Takano, Kumiko Asakawa, Izumi Fukuda, Izumi Sukegawa, Kazuo Shizume et al.
      Pages 105-112

  3. Insulin-Like Growth Factor Binding Proteins

    1. Insulin-Like Growth Factor Binding Protein Control Secretion and Mechanisms of Action

      • David R. Clemmons
      Pages 113-123

    2. Regulation and Actions of Insulin-Like Growth Factor Binding Protein-3

      • Robert C. Baxter, Janet L. Martin
      Pages 125-135

    3. Regulation of Gene Expression of Rat Insulin-Like Growth Factor Binding Proteins 1 and 2

      • Matthew M. Rechler, Alexandra L. Brown, Guck T. Ooi, Craig C. Orlowski, Lucy Y.-H. Tseng, Yvonne W.-H. Yang
      Pages 137-148

    4. Hormonal Regulation of Insulin-Like Growth Factor Binding Protein-1 Expression in the Rat

      • Liam J. Murphy, Jiangming Luo, Charita Seneviratne
      Pages 149-160

    5. Cerebrospinal IGF Binding Proteins : Isolation and Characterization

      • Michel Binoux, Monireh Roghani, Paul Hossenlopp, Odile Whitechurch
      Pages 161-170

    6. The Effect of Quantity and Nutritional Quality of Dietary Proteins on Plasma Concentration of Insulin-Like Growth Factor Binding Proteins (IGFBP) and the Saturability of IGFBP with Endogenous IGF-I

      • Hisanori Kato, Tsutomu Umezawa, Yutaka Miura, Tadashi Noguchi
      Pages 171-178

    7. Presence of Insulin-Like Growth Factors and Their Binding Proteins in Rat Milk

      • Anthony F. Philipps, Jean M. Wilson, Radhakrishna Rao, David M. McCracken, Otakar Koldovsky
      Pages 179-186

  4. Receptors for Insulin, IGF-I and II

    1. Molecular Heterogeneity of Insulin Receptors in Rat Tissues

      • Barry J. Goldstein, Alana L. Dudley
      Pages 187-195

    2. Mutations in the Insulin Receptor Gene in Patients with Genetic Syndromes of Insulin Resistance

      • Simeon I. Taylor, Domenico Accili, Alessandro Cama, Hiroko Kadowaki, Takashi Kadowaki, Eiichi Imano et al.
      Pages 197-213
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Keywords

About this book

This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.

Editors and Affiliations

  • University of Florida, Gainesville, USA

    Mohan K. Raizada

  • National Institutes of Health, Bethesda, USA

    Derek LeRoith

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