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Mechanisms of Lymphocyte Activation and Immune Regulation III

Developmental Biology of Lymphocytes

  • Book
  • © 1991

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Editors:
  1. Sudhir Gupta

    1. Department of Medicine, University of California, Irvine, USA

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  2. William E. Paul

    1. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

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  3. Max D. Cooper

    1. The Howard Hughes Medical Institute, University of Alabama, Birmingham, USA

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  4. Ellen V. Rothenberg

    1. Department of Biology, California Institute of Technology, Pasadena, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 292)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-ix
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  2. Phylogeny of Lymphocytes

    1. Immunoglobulin Genes and B Cell Development in Amphibians

      • L. Du Pasquier, J. Schwager
      Pages 1-9

    2. Evolutionary Development of Immunoglobulin Gene Diversity

      • G. W. Litman, C. T. Amemiya, F. A. Harding, R. N. Haire, K. R. Hinds, R. T. Litman et al.
      Pages 11-17

    3. Studies on the Ontogeny of the Immune Function in Birds

      • Nicole Le Douarin
      Pages 19-30

  3. Developmental Biology of T Lymphocytes

    1. Kinetics of Negative and Positive Selection in the Thymus

      • Pawel Kisielow, Harald von Boehmer
      Pages 31-42

    2. Life and Death of a T Cell

      • Dennis Y. Loh
      Pages 43-45

    3. First Wave Fetal Thymocytes Expressing V3Jγ1Cγ1-Vδ1Jδ2Cδ T Cell Receptors are not Required For αβ T Cell Receptor Rearrangement and Expression

      • David A. Ferrick, Donald Gajewski, Tak W. Mak
      Pages 47-51

    4. Diversity, Development, Ligands, and Probable Functions of γδ T Cells

      • Susumu Tonegawa, Anton Berns, Marc Bonneville, Andrew G. Farr, Isao Ishida, Kouich Ito et al.
      Pages 53-61

    5. γδ T Cells in Murine Epithelia: Origin, Repertoire, and Function

      • James P. Allison, David M. Asarnow, Mark Bonyhadi, Amy Carbone, Wendy L. Havran, Diphankar Nandi et al.
      Pages 63-69

    6. Acquisition of Mature Functional Responsiveness in T Cells: Programming for Function via Signaling

      • Ellen V. Rothenberg, Dan Chen, Rochelle A. Diamond, Mariam Dohadwala, Thomas J. Novak, Patricia M. White et al.
      Pages 71-83

    7. Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens

      • Christopher E. Rudd, Elizabeth K. Barber, Kristine E. Burgess, Julie Y. Hahn, Andreani D. Odysseos, Man Sun Sy et al.
      Pages 85-96

    8. Characterization of Triple Negative Clones Isolated from Post-Natal Human Thymus

      • Toshiyuki Hori, Hergen Spits
      Pages 97-104

    9. Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Th1 Clones in the Absence of Accessory Cells

      • Yang Liu, Charles A. Janeway Jr.
      Pages 105-113

    10. Identification of a Novel Thymocyte Growth Factor Derived from B Cell Lymphomas

      • Takashi Suda, Ian MacNeil, Melissa Fischer, Kevin W. Moore, Albert Zlotnik
      Pages 115-120

    11. Expression of Receptors for Interleukin 4 and Interleukin 7 on Human T Cells

      • Richard J. Armitage, Steven F. Ziegler, M. Patricia Beckmann, Rejean L. Idzerda, Linda S. Park, William C. Fanslow
      Pages 121-130

    12. Effects of Leukemia Inhibitory Factor (LIF) on Gene Transfer Efficiency into Murine Hematolymphoid Progenitors

      • Frederick A. Fletcher, Kateri A. Moore, Douglas E. Williams, Dirk Anderson, Charles Maliszewski, John W. Belmont
      Pages 131-138

  4. Mechanism of Tolerance Inductions

    1. Thymic Mechanisms for Inducing Tolerance to Mls

      • Fred Ramsdell, Tracy Lantz, Frances Hausman, B. J. Fowlkes
      Pages 139-147

    2. Cells Inducing Tolerance to Mls and H-2 Antigens

      • Susan R. Webb, Jonathan Sprent
      Pages 149-157

    3. Multiple Mechanisms of T Cell Tolerance to Mls-la

      • Marcia A. Blackman, John W. Kappler, Philippa Marrack
      Pages 159-165

    4. Induction and Maintenance of Anergy in Mature T Cells

      • Marc K. Jenkins, Daniel Mueller, Ronald H. Schwartz, Simon Carding, Kim Bottomley, Miguel J. Stadecker et al.
      Pages 167-176
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Keywords

About this book

Recent advances in the understanding of the major events that shape the immune recog­ nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec­ tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.

Editors and Affiliations

  • Department of Medicine, University of California, Irvine, USA

    Sudhir Gupta

  • Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

    William E. Paul

  • The Howard Hughes Medical Institute, University of Alabama, Birmingham, USA

    Max D. Cooper

  • Department of Biology, California Institute of Technology, Pasadena, USA

    Ellen V. Rothenberg

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