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Advances in Molecular Biology and Targeted Treatment for AIDS

  • Book
  • © 1991

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Editors:
  1. Ajit Kumar

    1. The George Washington University Medical Center, USA

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Viral DNA Replication and Integration

    1. Mechanistic Analysis of HIV-1 Reverse Transcriptase

      • John Abbotts, Samuel H. Wilson
      Pages 1-19

    2. Analyses of HIV Integration Components

      • Kathryn S. Jones, Joseph Kulkosky, Anna Marie Skalka
      Pages 21-26

    3. DNA Cleaving Activity of Purified Human Immunodeficiency Virus Integration Protein

      • Paula A. Sherman, James A. Fyfe
      Pages 27-33

    4. A Thermodynamic Analysis of the Binding of Nucleic Acid to HIV-1 Reverse Transcriptase

      • George R. Painter, Lois L. Wright, C. Webster Andrews, Nancy Cheng, Sam Hopkins, Phillip A. Furman
      Pages 35-50

    5. Rous Sarcoma Virus Gag Gene Sequences Affect Viral RNA Splicing and Stability

      • Mark T. McNally, George F. Barker, Karen Beemon
      Pages 51-54

    6. Ribonuclease H and Primer tRNA Binding Activities of HIV Reverse Transcriptase as Therapeutic Targets

      • Stuart F. J. Le Grice, Oktavian Schatz, Jean-Luc Darlix
      Pages 55-68

  3. Role of Viral Regulatory Genes

    1. Human-Specific Factors are Required for Tat-Mediated Trans-Activation of the HIV-1 and HIV-2 LTRs

      • Michael Newstein, Peter R. Shank
      Pages 69-77

    2. Role of the TAR Element in Regulating HIV Gene Expression

      • Richard Gaynor
      Pages 79-91

    3. Regulation of HIV-1 Gene Expression by the Tat Protein and the TAR Region

      • Michael F. Laspia, Shobha Gunnery, Mark Kessler, Andrew P. Rice, Michael B. Mathews
      Pages 93-105

    4. HIV-1 Tat: A Transcriptional Activator that Recognizes a Structured RNA Target

      • Ben Berkhout, Kuan-Teh Jeang
      Pages 107-121

    5. HIV-1 Tat trans-activates in the Absence of its Target

      • Mark J. Selby, B. Matija Peterlin
      Pages 123-131

    6. Trans-Activation Requires the Binding of the HIV-1 Tat Protein to Tar RNA

      • Colin Dingwall, Ingemar Ernberg, Michael J. Gait, Shaun Heaphy, Jonathan Karn, Michael Skinner
      Pages 133-143

    7. The HIV-1 Tat Transactivator Contains an Arginine-Glycine-Aspartyl (RGD) Cell Adhesion Site

      • David A. Brake, Christine Debouck
      Pages 145-150

    8. Inhibition of HIV-1 Replication by Mutant Tat Peptides

      • Paul M. Loewenstein, Masaho Ishino, Na’eem Abdullah, Maurice Green
      Pages 151-172

    9. RNA — Protein Interactions Required for Rev Mediated Regulation of HIV Gene Expression

      • Craig A. Rosen, Alan W. Cochrane, Patrick J. Dillon, Henrik S. Olsen
      Pages 173-181

    10. A 5’ Splice Site is Essential for REV and REX Regulation of HIV Envelope Protein mRNA Expression

      • Xiaobin Lu, Nancy Lewis, David Rekosh, Marie-Louise Hammarskjöld
      Pages 183-188

    11. Molecular Functional Studies of HIV-1 REV and NEF Proteins

      • Sundararajan Venkatesan, Steven M. Holland, Nafees Ahmad, Paul Wingfield, Ratan K. Maitra, H. Clifford Lane
      Pages 189-201

    12. Structure and Function of HIV and SIV Nef Proteins

      • Lee Ratner, Thomas M. J. Niederman, Homer Lozeron, Martin Bryant
      Pages 203-216

    13. Functional Analysis of the HIV-1 Gene Products vif and vpu

      • Klaus Strebel, Malcolm A. Martin
      Pages 217-223
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Keywords

About this book

Since the discovery of HIV-l as the etiologic agent of acquired immunodeficiency syndrome (AIDS) in the early 1980s, remarkable progress has been made in both the basic understanding of the biological processes leading to AIDS and an accelerated effort in finding new treatments. As is often the case in rapidly advancing fields, most of the scientific discussions are best handled in specialized groups. The effort to organize a meeting on advances in molecular biology and targeted treatment for AIDS was an experiment of sorts to gather experts in selected areas of overlapping interests where advances in basic biology and its application in the development of new drugs could be discussed. Of necessity, the scope of the meeting had to be limited to maintain a certain focus. Important areas of rapid development in AIDS research, such as the vaccine development, epidemiology, animal models, etc. , had to be left out for more specialized meetings. The result, from all accounts, appeared to be quite a successful gathering, which provided a forum for informal discussions among scientists from industry and academic institutions. A remarkable feature of the AIDS virus is its genetic complexity and how some of its seemingly "extra genes" manage to regulate the normal functions of the host and most importantly its immune system.

Editors and Affiliations

  • The George Washington University Medical Center, USA

    Ajit Kumar

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