Kindling 4

1. Front Matter

   Pages i-xiii

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2. Kindling as a Model of Long-Lasting Plasticity: New Perspectives in the Search for Molecular Mechanisms

   • Gildas Le Gal La Salle

   Pages 1-9

3. Spontaneous Electrographic Seizures in the Hippocampal Slice: An In Vitro Model for the Study of the Transition from Interictal Bursting to Ictal Activity

   • Darrell V. Lewis, Wilkie A. Wilson

   Pages 11-19

4. Is the Pyriform Cortex Important for Limbic Kindling?

   • Dan C. McIntyre, Mary Ellen Kelly

   Pages 21-31

5. Metabolic Maps of Kindling: A Sequential Double-Label Deoxyglucose Study

   • Kenji Ono, Hiroshi Baba, Shuhei Nishimura, Juhn A. Wada

   Pages 33-44

6. Seizure Mechanisms in the Piriform Cortex

   • Jeffrey S. Stripling, Doris K. Patneau

   Pages 45-59

7. Double-Label Quantitative Autoradiographic Studies of Anaerobic Glucose Metabolism in Limbic Seizures

   • Robert F. Ackermann, James L. Lear

   Pages 61-73

8. Alterations of Synaptic Ultrastructure Induced by Hippocampal Kindling

   • Yuri Geinisman, Frank Morrell, Leyla deToledo-Morrell

   Pages 75-92

9. Forebrain and Brainstem Mechanisms Governing Kindled Seizure Development: A Hypothesis

   • James L. Burchfiel, Craig D. Applegate

   Pages 93-112

10. Genetic Contributions to Kindling: An Experimental Approach

    • Craig D. Applegate, James L. Burchfiel, Paul E. Neumann

    Pages 113-126

11. The GABA Hypothesis of Kindling

    • W. McIntyre Burnham, Georgia A. Cottrell

    Pages 127-139

12. Noradrenaline and Kindling Revisited

    • Michael E. Corcoran, Gerald K. Weiss

    Pages 141-156

13. Mechanisms of Kindling in Developing Animals

    • Ellen F. Sperber, Kurt Haas, Solomon L. Moshé

    Pages 157-168

14. The Kindling Process and Vulnerability to Status Epilepticus

    • Gary G. Buterbaugh, Gail M. Hudson

    Pages 169-183

15. Frequency- and Time-Domain EEG Topographic Analysis of the Amygdala Kindling Evolution in the Cat

    • Augusto Fernández-Guardiola, Rodrigo Fernández-Mas, Adrián Martínez, Luisa Rocha, Rafael Gutiérrez

    Pages 185-196

16. N-Methyl-D-Aspartate (NMDA) Receptors and the Kindling Model

    • James O. McNamara, Douglas W. Bonhaus, J. Victor Nadler, Geng-Chang Yeh

    Pages 197-208

17. Does Electrical and Excitatory Amino Acid Kindling Share a Common Neurobiological Mechanism?

    • Norio Mori, Juhn A. Wada

    Pages 209-225

18. Involvement of Excitatory Amino Acids in the Mechanisms of Kindling

    • Gérard Rondouin, Mireille Lerner-Natoli, Robert Chicheportiche, Jean-Marc Kamenka

    Pages 227-239

19. Kindling and Excitatory Amino Acids

    • Mitsumoto Sato, Kiyoshi Morimoto, Kazufumi Akiyama, Motoi Okamoto

    Pages 241-251

20. Effect of Selective Lesions within the Substantia Nigra on the Anticonvulsant Effect of Antiepileptic Drugs in Fully-Kindled Rats

    • Wolfgang Löscher, Ulrich Wahnschaffe, Dagmar Hönack, Chris Rundfeldt

    Pages 253-266

This is the proceedings of the fourth in a series of inter­ national gatherings on kindling held on the University of British Columbia campus, June 15-17, 1989. Since the last gath­ ering in 1985, kindling continues to attract an ever-increasing number of investigators as reflected by the phenomenal increase in the number of kindling-related research reports. No other acute or chronic model has been exploited so extensively using electrophysiological, pharmacological, biochemical and behav­ ioural approaches involving a variety of brain sites and ani­ mal species. The continuing search, during the past few years, for the mechanism underlying the enduring change induced by kindling is beginning to shed some light on aspects of its molecular basis and to suggest the future direction of research. The late Graham Goddard, the original kindler, would have been delighted with this development. We were all shocked and saddened by his tragic death, but his spirit is very much alive among all of us who gathered together to share new information and collectively reassess the present state of knowledge at this symposium. I must say that we miss him very, very much. We know he is happy in his heaven knowing that he accomplished more in a short lifetime than most and that his love for mankind, and life's challenges, remain as a legacy, and goal, for us all.

• Aspartat
• adenosine
• amino acid
• anatomy
• brain
• brainstem
• cortex
• development
• electroencephalography (EEG)
• epilepsy
• evolution
• forebrain
• metabolism
• pharmacology
• receptor

• Neurosciences and Neurology, University of British Columbia, Vancouver, Canada

  Juhn A. Wada

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