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Protein Design and the Development of New Therapeutics and Vaccines

  • Book
  • © 1990

Overview

Editors:
  1. Jerry B. Hook

    1. Smithkline Beecham Pharmaceuticals, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. George Poste

    1. Smithkline Beecham Pharmaceuticals, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Judy Schatz
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: New Horizons in Therapeutics (NHTH)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Advances in the Structural Analysis of Proteins

    1. Front Matter

      Pages 1-1
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    2. Dynamic Processes in Proteins by X-Ray Diffraction

      • Dagmar Ringe, Steven C. Almo, Gregory K. Farber, Janos Hajdu, P. Lynne Howell, Gregory A. Petsko et al.
      Pages 3-21

    3. Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins

      • Klaus Biemann
      Pages 23-46

  3. Protein Folding and Stability

    1. Front Matter

      Pages 47-47
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    2. Protein Folding and Stability

      • Robert L. Baldwin
      Pages 49-57

    3. Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo

      • Jonathan King, Ben Fane, Cameron Haase-Pettingell, Anna Mitraki, Robert Villafane
      Pages 59-78

    4. Unfolding and Inactivation

      • Ronald Wetzel, L. Jeanne Perry, Michael G. Mulkerrin, L. Michael Randall
      Pages 79-115

  4. Principles of Receptor Design and Regulation

    1. Front Matter

      Pages 117-117
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    2. Protein—Tyrosine Kinases and Their Substrates

      • Tony Hunter, Kathleen L. Gould, Richard A. Lindberg, Jill Meisenhelder, David S. Middlemas, David P. Thompson
      Pages 119-139

  5. The Guanine Nucleotide Binding Protein Family

    1. Front Matter

      Pages 141-141
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    2. G Proteins

      • Eva J. Neer
      Pages 143-153

    3. Model of Signal Transduction by G Proteins

      • Lutz Birnbaumer, Atsuko Yatani, Ravi Iyengar, John D. Hildebrandt, Juan Codina, Arthur M. Brown
      Pages 155-178

    4. Structural Homologies in G-Binding Proteins

      • Brian F. C. Clark, Michael Jensen, Morten Kjeldgaard, Søren Thirup
      Pages 179-206

  6. Modeling and Structure Prediction in Macromolecules

    1. Front Matter

      Pages 207-207
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    2. Knowledge-Based Protein Modeling and the Design of Novel Molecules

      • Tom L. Blundell, Mark S. Johnson, John P. Overington, Andrej Šali
      Pages 209-227

    3. Computer Simulation Methods as Applied to Site-Specific Mutations

      • Peter Kollman
      Pages 229-236

    4. Dihydrofolate Reductase

      • Stephen J. Benkovic, Carston R. Wagner
      Pages 237-249

  7. Protein Engineering and Enzyme Design

    1. Front Matter

      Pages 251-251
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    2. Chemical Approaches to Protein Engineering

      • Robin E. Offord
      Pages 253-282
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Keywords

Editors and Affiliations

  • Smithkline Beecham Pharmaceuticals, Philadelphia, USA

    Jerry B. Hook, George Poste

Bibliographic Information

  • Book Title: Protein Design and the Development of New Therapeutics and Vaccines

  • Editors: Jerry B. Hook, George Poste, Judy Schatz

  • Series Title: New Horizons in Therapeutics

  • DOI: https://doi.org/10.1007/978-1-4684-5739-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1990

  • Softcover ISBN: 978-1-4684-5741-4Published: 13 March 2012

  • eBook ISBN: 978-1-4684-5739-1Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XXII, 512

  • Number of Illustrations: 77 b/w illustrations

  • Topics: Pharmacology/Toxicology, Biochemistry, general

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