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Antioxidants in Therapy and Preventive Medicine

  • Book
  • © 1990

Overview

Editors:
  1. Ingrid Emerit

    1. Centre National de la Recherche Scientifique, University of Paris, Paris, France
      Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, Paris, France

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  2. Lester Packer

    1. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Christian Auclair

    1. Institut Gustave-Roussy, Villejuif, France

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 264)

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Table of contents (85 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Superoxide Dismutase

    1. Extracellular-Superoxide Dismutase, Distribution in the Body and Therapeutic Applications

      • Stefan L. Marklund, Kurt Karlsson
      Pages 1-4

    2. Targeting Sod by Gene and Protein Engineering and Inhibition of Oxidative Stress in Various Diseases

      • Masayasu Inoue, Nobukazu Watanabe
      Pages 5-12

    3. The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury

      • K. Grabitz, E. Freye, R. Prior, R. Kolvenbach, W. Sandmann
      Pages 13-16

    4. Sod in Rat Models of Shock and Organ Failure

      • Heinz Redl, Camille Lieners, Soheyl Bahrami, Günther Schlag, Ignaz P. T. van Bebber, R. Jan A. Goris
      Pages 17-27

    5. The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase

      • Marc Fontecave, Peter Reichard
      Pages 29-35

    6. Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed During DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition

      • Enrique Cadenas, Lars Ernster
      Pages 37-44

  3. Copper Complexes and Other Sod Mimicks

    1. Superoxide Scavengers and SOD or SOD Mimics

      • Gidon Czapski, Sara Goldstein
      Pages 45-50

    2. Reactivity of Active Centre Analogues of Cu2Zn2Superoxide Dismutase

      • Ulrich Weser, Ralf Miesel, Margot Linss
      Pages 51-57

    3. SOD Mimicking Properties of Copper (II) Complexes: Health Side Effects

      • Gérard Lapluye
      Pages 59-68

    4. Radiation Recovery Agents: Cu(II), Mn(II), Zn(II), OR Fe(III) 3,5-Diisopropylsalicylate Complexes Facilitate Recovery from Ionizing Radiation Induced Radical Mediated Tissue Damage

      • John J. R. Sorenson, Lee S. F. Soderberg, Max L. Baker, John B. Barnett, Louis W. Chang, Hamid Salari et al.
      Pages 69-77

    5. Effects of Glycyl-Histidyl-Lysyl Chelated Cu(II) on Ferritin Dependent Lipid Peroxidation

      • D. M. Miller, D. DeSilva, L. Pickart, S. D. Aust
      Pages 79-84

    6. SOD-Like Activity of 5-Membered Ring Nitroxide Spin Labels

      • Amram Samuni, Ahn Min, C. Murali Krishna, James B. Mitchell, Angelo Russo
      Pages 85-92

  4. Antioxidant Vitamins

    1. Vitamin E in Biological Systems

      • Lester Packer, Sharon Landvik
      Pages 93-103

    2. The Role of Vitamin E in the Hepatotoxicity by Glutathione Depleting Agents

      • Alessandro F. Casini, Emilia Maellaro, Barbara Del Bello, Mario Comporti
      Pages 105-110

    3. Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase

      • Aalt Bast, Guido R. M. M. Haenen
      Pages 111-116

    4. Quenching of Singlet Molecular Oxygen by Tocopherols

      • Stephan Kaiser, Paolo Di Mascio, Michael E. Murphy, Helmut Sies
      Pages 117-124

    5. Antioxidant Properties of Vitamin E and Membrane Permeability in Human Fibroblast Cultures

      • Marc Conti, Martine Couturier, Frédérique Lemonnier, Alain Lemonnier
      Pages 125-128

    6. Vitamin E and Tumor Growth

      • Mariette Gerber, Sylvia Richardson, François Favier, André Crastes De Paulet
      Pages 129-132

    7. Abnormal Susceptibility to Lipid Peroxidation of Plasma LDL and Its Prevention by α-Tocopherol During Experimental Cholestasis in the Rat

      • L. G. Alcindor, H. Antebi, M. Fadel-Khadra, M-C. Piot, Y. Giudicelli, R. Nordmann
      Pages 133-137
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Keywords

About this book

Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.

Editors and Affiliations

  • Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  • Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, Paris, France

    Ingrid Emerit

  • Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, USA

    Lester Packer

  • Institut Gustave-Roussy, Villejuif, France

    Christian Auclair

Bibliographic Information

  • Book Title: Antioxidants in Therapy and Preventive Medicine

  • Editors: Ingrid Emerit, Lester Packer, Christian Auclair

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5730-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1990

  • Softcover ISBN: 978-1-4684-5732-2Published: 03 April 2012

  • eBook ISBN: 978-1-4684-5730-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 608

  • Topics: Pharmacology/Toxicology, Nuclear Medicine, Ultrasound, Biochemistry, general

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