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Novel Approaches to the Treatment of Alzheimer’s Disease

  • Book
  • © 1989

Overview

Editors:
  1. Edwin M. Meyer

    1. University of Florida, Gainesville, USA

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  2. James W. Simpkins

    1. University of Florida, Gainesville, USA

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  3. Jyunji Yamamoto

    1. Taiho Pharmaceuticals, Ltd., Tokushima, Japan

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Part of the book series: Advances in Behavioral Biology (ABBI, volume 36)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Drugs That Act at Cholinergic Receptors

    1. A Functionalized Congener Approach to Muscarinic Ligands

      • Kenneth A. Jacobson, Barton J. Bradbury, Jesse Baumgold
      Pages 1-9

    2. AF102B: A Novel M1 Agonist as a Rational Treatment Strategy in Alzheimer’s Disease

      • Abraham Fisher, Rachel Brandeis, Ishai Karton, Zipora Pittel, Shlomit Dachir, Michal Sapir et al.
      Pages 11-16

    3. Muscarinic Receptors, Phosphoinositide Hydrolysis, and Neuronal Plasticity in the Hippocampus

      • Fulton T. Crews, Norbert J. Pontzer, L. Judson Chandler
      Pages 17-24

    4. Effects of Cholinergic Drugs on Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied by Brain Dialysis

      • Katsuo Toide, Takashi Arima
      Pages 25-38

    5. Delayed Matching-to-Sample in Monkeys as a Model for Learning and Memory Deficits: Role of Brain Nicotinic Receptors

      • William J. Jackson, Karey Elrod, Jerry J. Buccafusco
      Pages 39-52

    6. Muscarinic and Nicotinic Receptors in Alzheimer’s Disease: Rationale for Cholinergic Drug Treatment

      • Paul A. Lapchak, Dalia M. Araujo, Remi Quirion
      Pages 53-61

  3. CNS-Active Neurotrophic Factors

    1. Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseases

      • Franz Hefti
      Pages 63-70

    2. The Use of Reaggregating Cell Cultures And Immortalized Central Nervous System Cells to Study Cholinergic Trophic Mechanisms

      • B. H. Wainer, H. J. Lee, J. D. Roback, D. N. Hammond
      Pages 71-94

    3. Approaches to Gene Therapy in the CNS: Intracerebral Grafting of Fibroblasts Genetically Modified to Secrete Nerve Growth Factor

      • Michael B. Rosenberg, Mark H. Tuszynski, Kazunari Yoshida, Theodore Friedmann, Fred H. Gage
      Pages 95-101

    4. Exogenous Nerve Growth Factor Stimulates Choline Acetyltransferase Activity in Basal Forebrain of Axotomized and Aged Rats

      • Lawrence R. Williams, Karen S. Jodelis, Melody R. Donald, Henry K. Yip
      Pages 103-115

    5. Neuronotrophic Factors, Gangliosides and Their Interaction: Implications in the Regulation of Nervous System Plasticity

      • Stephen D. Skaper, Alberta Leon, Gino Toffano
      Pages 117-126

    6. Suppression of Active Neuronal Death by Immune Interferon

      • Eugene M. Johnson Jr., David P. Martin, Beth K. Levy, Jason Y. Chang
      Pages 127-132

    7. Basic Fibroblast Growth Factor, an Example of a Multifunctional Trophic Factor with Neurotrophic Activity

      • Patricia Ann Walicke
      Pages 133-151

    8. Growth Factor and Lymphokine Effects on Brain Cholinergic Systems

      • Dalia M. Araujo, Paul A. Lapchak, Jean-Guy Chabot, Remi Quirion
      Pages 153-163

    9. Metabolic Support of Neural Plasticity: Implications for the Treatment of Alzheimer’s Disease

      • James E. Black, William T. Greenough
      Pages 165-171

  4. Additional Novel Treatment Strategies: Improved Brain Delivery, Hormones, and Immunology

    1. Brain-Enhanced Delivery of Anti-Dementia Drugs

      • Marcus E. Brewster, Cynthia Robledo-Luiggi, Akio Miyakeb, Emil Pop, Nicholas Bodor
      Pages 173-183

    2. Development of a Pyrrolidinone Derivative (Cyclic GABA) for Modulating Brain Glutamate Transmission

      • Kenji Matsuyama, Choichiro Miyazaki, Masataka Ichikawa
      Pages 185-196

    3. A Brain-Enhanced Chemical Delivery System for Gonadal Steroids: Implications for Neurodegenerative Diseases

      • James W. Simpkins, Mohamad H. Rahimy, Nicholas Bodor
      Pages 197-212

    4. Immunologic Approach to Therapy in Alzheimer’s Disease

      • Vijendra K. Singh, Reed P. Warren
      Pages 213-220
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Keywords

About this book

Alzheimer's disease afflicts up to 1 in 5 people over the age of 65 years and causes untold suffering of the patient and their family. The cause of this disease is unknown; indeed, evidence increasingly suggests that there may be multiple Alzheimer-type syndromes with different etiologies, analogous to different types of psychosis. Currently there are no means to prevent the disease, slow its progress or reverse its neurodegenerative consequences. With few exceptions, clinical trials of a variety of compounds have resulted in patient responses that are disappointing with respect to both the proportion of responders and the magnitude of the responses. Novel approaches to the treatment of Alzheimer's disease are clearly warranted. For this reason, we organized the First Suncoast Workshop on the Neurobiology of Aging in St. Petersburg, Florida, which took place from February 26-March 1, 1989. This workshop focused on novel treatments and models for Alzheimer's disease and represented a cooperative venture among academia, government and industry, both in its participants and sponsorship. The Center for the Neurobiology of Aging at the University of Florida, the National Institute on Aging and Taiho Pharmaceutical Corporation in Japan sponsored the workshop in which scientists from the North America, Europe, Japan and other parts of Asia participated.

Editors and Affiliations

  • University of Florida, Gainesville, USA

    Edwin M. Meyer, James W. Simpkins

  • Taiho Pharmaceuticals, Ltd., Tokushima, Japan

    Jyunji Yamamoto

Bibliographic Information

  • Book Title: Novel Approaches to the Treatment of Alzheimer’s Disease

  • Editors: Edwin M. Meyer, James W. Simpkins, Jyunji Yamamoto

  • Series Title: Advances in Behavioral Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5727-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4684-5729-2Published: 25 November 2012

  • eBook ISBN: 978-1-4684-5727-8Published: 09 March 2013

  • Series ISSN: 0099-6246

  • Edition Number: 1

  • Number of Pages: XIV, 386

  • Number of Illustrations: 137 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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