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Biologically Based Methods for Cancer Risk Assessment

  • Book
  • © 1989

Overview

Editors:
  1. Curtis C. Travis

    1. Office of Risk Analysis, Oak Ridge National Laboratory, Oak Ridge, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 159)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    1. Research Needs for Biologically Based Risk Assessment

      • Curtis C. Travis
      Pages 1-7

  4. Interspecies Extrapolation of Pharmacokinetics

    1. Interspecies Extrapolation

      • Curtis C. Travis
      Pages 63-78

    2. Comparative Carcinogenesis : Is There a Theoretical Approach to Inter-Species Similarity ?

      • P. Tautu
      Pages 79-109

    3. Biological Basis for Interspecies Extrapolations of Halogenated Solvents and of 1,3-Butadiene

      • Hermann M. Bolt, Reinhold J. Laib
      Pages 111-122

    4. Species-Specific Inhalation Pharmacokinetics of 2-Nitropropane, Methyl Ethyl Ketone, and n-Hexane

      • Winfried Kessler, Barbara Denk, Johannes G. Filser
      Pages 123-139

  5. Promotion as a Factor in Carcinogenesis

    1. Overview of Promotion as a Mechanism in Carcinogenesis

      • Monique Castagna, Isabelle Martelly
      Pages 141-153

    2. Hepatocarcinogenesis by Non-Genotoxic Compounds

      • R. Schulte-Hermann, W. Parzefall, W. Bursch, I. Timmermann-Trosiener
      Pages 155-163

    3. The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessment from Exposure to Chemicals

      • J. E. Trosko, C. C. Chang
      Pages 165-179

    4. Comparative Analyses of the Timing and Magnitude of Genotoxic and Nongenotoxic Cellular Effects in Urinary Bladder Carcinogenesis

      • Leon B. Ellwein, Samuel M. Cohen
      Pages 181-192

    5. Alterations in Gene Expression in Mouse Hepatocarcinogenesis

      • Tommaso A. Dragani, Giacomo Manenti, Marina R. M. Sacchi, Bruno Colombo, Giuseppe Della Porta
      Pages 193-207

  6. Screening for Carcinogenesis

    1. Medium-Term Bioassay Models for Environmental Carcinogens — Two-Step Liver and Multi-Organ Carcinogenesis Protocols

      • Nobuyuki Ito, Hiroyuki Tsuda, Ryohei Hasegawa, Masae Tatematsu, Katsumi Imaida, Makoto Asamoto
      Pages 209-230

    2. The Use of ALDH Induction as a Carcinogenic Risk Marker in Comparison with Typical in Vitro Mutagenicity System

      • V. Vasiliou, K. Athanasiou, M. Marselos
      Pages 231-240

    3. Expression of Inducible Cytochrome P-450 mRNAs During Promotion of Experimental Chemical Hepatocarcinogenesis

      • Maria Celeste Lechner
      Pages 241-254

    4. An in Vitro Approach for Interspecies Extrapolation Using Animal and Human Airway Epithelial Cell Culture

      • M. Emura, M. Riebe, U. Mohr, J. Jacob, G. Grimmer, J. Wen et al.
      Pages 255-273
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Keywords

About this book

"Biologically Based Methods for Cancer Risk Assessment", an Advanced Research Workshop, (ARW) sponsored by the North Atlantic Treaty Organization (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation of such methods represents one of the most challenging areas for risk assessment. The workshop included an international group of invited experts in the field and provided for a dynamic exchange of ideas and accomplishments. Some of the major topics discussed were: * Inventory of available pharmacokinetic and pharmacodynamic methods for cancer risk assessment. * Identification of methodology gaps and research needs in biologically based methods in cancer risk assessment. * Development of a general framework to guide future cancer risk assessment research. This book is a compilation of the papers presented at the workshop and is intended to provide guidance for future research to reduce uncertainties in the cancer risk assessment process. The primary sponsorship of this ARW by NATO and the advice and cooperation of Dr. C. Sinclair of the Scientific affairs Division are gratefully acknowledged. Acknowledgement is also given to the National Science Foundation for its support. The organization of the ARW and the preparation of this book have required considerable help from many other sources.

Editors and Affiliations

  • Office of Risk Analysis, Oak Ridge National Laboratory, Oak Ridge, USA

    Curtis C. Travis

Bibliographic Information

  • Book Title: Biologically Based Methods for Cancer Risk Assessment

  • Editors: Curtis C. Travis

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5625-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4684-5627-1Published: 30 April 2013

  • eBook ISBN: 978-1-4684-5625-7Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: IX, 355

  • Number of Illustrations: 54 b/w illustrations

  • Topics: Oncology

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