Clinical Aspects of Neutron Capture Therapy

1. Front Matter

   Pages i-xiii

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2. Dose Rate and Therapeutic Gain

   1. Dose Rate and Therapeutic Gain

      • R. G. Fairchild

      Pages 1-7

3. Swine Skin: A Model to Evaluate Dose Recovery from Different Radiations

   1. Swine Skin: A Model to Evaluate Dose Recovery from Different Radiations

      • J. O. Archambeau

      Pages 9-20

4. Neutron Capture Therapy in Support of Other Radiation Treatment

   1. Neutron Capture Therapy in Support of Other Radiation Treatment

      • Borje Larsson

      Pages 21-26

5. Research on Neutron Capture Therapy in the USSR

   1. Research on Neutron Capture Therapy in the USSR

      • Yuri Ryabukhin

      Pages 27-38

6. BNCT Project in Czechoslovakia

   1. BNCT Project in Czechoslovakia

      • J. Burian, I. Janku, J. Kvitek, V. Mares, Z. Prouza, F. Spurny et al.

      Pages 39-48

7. Proposed Clinical Trial Studying the Pharmacokinetics of B.S.H.

   1. Proposed Clinical Trial Studying the Pharmacokinetics of B.S.H.

      • William Frederic James Harkness

      Pages 49-51

8. Fractionation in Boron Neutron Capture Therapy

   1. Fractionation in Boron Neutron Capture Therapy

      • K. R. Durrant, J. Hopewell

      Pages 53-61

9. Dose Fractionation in Neutron Capture Therapy for Malignant Melanoma

   1. Dose Fractionation in Neutron Capture Therapy for Malignant Melanoma

      • B. J. Allen, J. K. Brown

      Pages 63-67

10. Thermal Neutron Capture Therapy: The Japanese-Australian Clinical Trial for Malignant Melanoma

    1. Thermal Neutron Capture Therapy: The Japanese-Australian Clinical Trial for Malignant Melanoma

       • B. J. Allen, A. S. Coates, W. H. McCarthy, H. Mameghan, Y. Mishima, M. Ichihashi

       Pages 69-73

11. BNCT and Dose Fractionation

    1. BNCT and Dose Fractionation

       • John L. Russell Jr.

       Pages 75-79

12. Some Thoughts on Tolerance, dose, and Fractionation in Boron Neutron Capture Therapy

    1. Some Thoughts on Tolerance, Dose, and Fractionation in Boron Neutron Capture Therapy

       • Reinhard Gahbauer, Joseph Goodman, Thomas Blue

       Pages 81-85

13. Delayed Effects of Neutron Irradiation on Central Nervous System Microvasculature in the Rat

    1. Delayed Effects of Neutron Irradiation on Central Nervous System Microvasculature in the Rat

       • J. H. Goodman, J. M. McGregor, N. R. Clendenon, W. A. Gordon, A. J. Yates, R. A. Gahbauer et al.

       Pages 87-93

14. Pre-Clinical Studies on Boron Neutron Capture Therapy

    1. Pre-Clinical Studies on Boron Neutron Capture Therapy

       • Rolf F. Barth, Albert H. Soloway, Fazlul Alam, Nancy R. Clendenon, Thomas E. Blue, Naoki Mafune et al.

       Pages 95-105

15. Boron Compounds for Neutron Capture Therapy

    1. Boron Compounds for Neutron Capture Therapy

       • F. Alam, A. H. Soloway, B. V. Bapat, R. F. Barth, D. M. Adams

       Pages 107-111

16. Fractionation Considerations for Boron Neutron Capture Therapy: The Perspective of a Clinician

    1. Fractionation Considerations for Boron Neutron Capture Therapy: The Perspective of a Clinician

       • Allen G. Meek

       Pages 113-114

17. Vascular Factors Affecting Drug Delivery to Brain Tumors

    1. Vascular Factors Affecting Drug Delivery to Brain Tumors

       • George Tyson, Joseph Fenstermacher, Raphael Davis

       Pages 115-120

18. Clinical Considerations in the Use of Thermal and Epithermal Neutron Beams for Neutron Capture Therapy

    1. Clinical Considerations in the Use of Thermal and Epithermal Neutron Beams for Neutron Capture Therapy

       • Robert G. A. Zamenhof, Hywel Madoc-Jones, Otto K. Harling, John A. Bernard Jr.

       Pages 121-134

19. A Proposed Protocol for Clinical Trials of Boron Neutron Capture Therapy in Glioblastoma Multiforme

    1. A Proposed Protocol for Clinical Trials of Boron Neutron Capture Therapy in Glioblastoma Multiforme

       • Ronald V. Dorn III, John H. Spickard, Merle L. Griebenow

       Pages 135-144

20. The Effect of Ionizing Radiation on the Blood-Brain-Barrier (BBB): Considerations for the Application of Boron Neutron Capture Therapy (BNCT) of Brain Tumors

    1. The Effect of Ionizing Radiation on the Blood-Brain-Barrier (BBB): Considerations for the Application of Boron Neutron Capture Therapy (BNCT) of Brain Tumors

       • Ronald V. Dorn III, John H. Spickard, Merle L. Griebenow

       Pages 145-152

Since Locher first suggested Boron Neutron Capture Therapy (BNCT) in 1936, this theoretically ideal system has intrigued investigators. Unfortunately, the first clinical trials between 1951-1961 were not successful. However, they served to implant firmly the seed of BNCT, the growth of which has been carefully nurtured at a number of locations world-wide. This fact is attested to by the ongoing clinical trials in Japan as well as by the presence of researchers from active groups in the ten countries represented at this Workshop. In 1983 and 1985, the first and second international biannual symposia on BNCT were held, in response to a resurgence of interest in this field. In 1986, the DOE sponsored a workshop on NCT, in large part directed toward evaluating the national effort and the various neutron sources available within the United States. It now seems likely, because of various factors including improved neutron beams and boron delivery systems which have made the modality more attractive, that clinical trials will be initiated in the United States within the next few years. This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project. Our purpose is to facilitate our endeavor to incorporate the best procedures and techniques in the upcoming clinical trials.

• Tumor
• brain
• clinical trial
• diagnosis
• growth
• implant
• magnetic resonance
• magnetic resonance imaging
• magnetic resonance imaging (MRI)
• radiation
• research
• therapy
• Diagnostic Radiology

• Brookhaven National Laboratory, Upton, USA

  Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito

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