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The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy

  • Book
  • © 1988

Overview

Editors:
  1. Youcef Rustum

    1. Roswell Park Memorial Institute, Buffalo, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. John J. McGuire

    1. Roswell Park Memorial Institute, Buffalo, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 244)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Determinants of Response to Fluoropyrimidines in Combination with CF

    1. Overview: Rational Basis for Development of Fluoropyrimidine/5-Formyltetrahydrofolate Combination Chemotherapy

      • F. M. Huennekens, Y. D. Montejano, K. S. Vitols
      Pages 1-11

    2. The Natural and Unnatural Diastereomers of Leucovorin: Aspects of their Cellular Pharmacology

      • Richard Bertrand, Jacques Jolivet
      Pages 13-24

    3. Distribution and Metabolism of Calcium Leucovorin in Normal and Tumor Tissue

      • Robert J. Mullin, Barry R. Keith, David S. Duch
      Pages 25-38

    4. Role of Dosf, Schedule and Route of Administration of 5-Formyltetra-Hydrofolate: Preclinical and Clinical Investigations

      • Y. M. Rustum, L. Liu, Z. Zhang
      Pages 39-52

    5. Pharmacokinetic Analysis of (6S)-5-Formyltetrahydrofolate (1-CF), (6R)-5-Formyltetrahydrofolate (d-CF) and 5-Methyltetrahydrofolate (5-CH3-THF) in Patients Receiving Constant i.v. Infusion of High-Dose (6R,S)-5-Formyltetrahydrofolate (Leucovorin)

      • J. A. Straw, E. M. Newman
      Pages 53-58

  3. Evidence for Thymidylate Synthase as the Critical Site of Action of Fluoropyrimidines in Combination with CF

    1. The Role of Thymidylate Synthase in the Response to Fluoropyrimidine-Folinic Acid Combinations

      • Sondra H. Berger, Stephen T. Davis, Karen W. Barbour, Franklin G. Berger
      Pages 59-69

    2. Tumor Cell Responses to Inhibition of Thymidylate Synthase

      • Richard G. Moran, Khandan Keyomarsi, Ramesh Patel
      Pages 71-83

    3. Selectivity of CF and 5-Fluorouracil: Critical Role of Polyglutamylation

      • Janet A. Houghton, Larry G. Williams, Siebold S. N. deGraaf, Saeed Radparvar, Irving W. Wainer, John R. Rodman et al.
      Pages 85-95

    4. Methods for Thymidylate Synthase Pharmacodynamics: Serial Biopsy, Free and Total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu Assays

      • Colin Paul Spears, Bengt G. Gustavsson
      Pages 97-106

    5. The Treatment of Metastatic Breast Cancer with 5-Fluorouracil and Leucovorin

      • C. J. Allegra, G. F. Egan, J. C. Drake, S. M. Steinberg, S. M. Swain
      Pages 107-112

    6. Thymidylate Synthase and Fluorouracil

      • Kathryn M. Ivanetich, Daniel V. Santi
      Pages 113-125

    7. Mechanisms for Cisplatin-FUra Synergism and Cisplatin Resistance in Human Ovarian Carcinoma Cells both in vitro and in vivo

      • K. J. Scanlon, Y. Lu, M. Kashani-Sabet, J. x. Ma, E. Newman
      Pages 127-135

  4. Summation of Session 1 and 2

    1. Summation of Session 1

      • John J. McGuire
      Pages 137-137

    2. Summation of Session II

      • Peter V. Danenberg
      Pages 139-141

  5. Therapeutic Efficacy and Toxicity of Fluoropyrimidines in Combination with CF

    1. The Roswell Park Memorial Institute and Gastrointestinal Tumor Study Group Phase III Experience with the Modulation of 5-Fluorouracil by Leucovorin in Metastatic Colorectal Adenocarcinoma

      • Nicholas J. Petrelli, Youcef M. Rustum, Howard Bruckner, Donald Stablein
      Pages 143-155

    2. Mount Sinai Clinical Experience with Leucovorin and 5-Fluorouracil

      • Howard W. Bruckner
      Pages 157-166

    3. High-Dose Weekly Oral Leucovorin and 5-Fluorouracil in Previously Untreated Patients with Advanced Colorectal Carcinoma: A Phase I Study

      • John D. Hines, David J. Adelstein, Jeffrey L. Spiess, Susan Gear Carter, Joan E. Trey
      Pages 167-172

    4. A Controlled Clinical Trial Including Folinic Acid at Two Distinct Dose Levels in Combination with 5-Fluorouracil (5FU) for the Treatment of Advanced Colorectal Cancer: Experience of the Mayo Clinic and North Central Cancer Treatment Group

      • Michael J. O’Connell
      Pages 173-184

    5. 5-Fluorouracil (FUra) and Folinic Acid (FA) Therapy in Patients with Colorectal Cancer

      • Charles Erlichman
      Pages 185-192
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Keywords

Editors and Affiliations

  • Roswell Park Memorial Institute, Buffalo, USA

    Youcef Rustum, John J. McGuire

Bibliographic Information

  • Book Title: The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy

  • Editors: Youcef Rustum, John J. McGuire

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5607-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1988

  • Softcover ISBN: 978-1-4684-5609-7Published: 29 April 2012

  • eBook ISBN: 978-1-4684-5607-3Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 336

  • Topics: Oncology

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