Risk Assessment and Decision Making Using Test Results

1. Front Matter

   Pages i-viii

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2. Basics of the CPBS Approach to Risk Assessment and Decision Making

   1. Front Matter

      Pages 1-1

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   2. The Carcinogenicity Prediction and Battery Selection Approach

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 3-14

   3. Fundamental Basics of the CPBS Approach

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 15-63

3. Carcinogenicity Prediction and Battery Selection Methodology

   1. Front Matter

      Pages 65-66

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   2. Preliminary Analysis

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 67-123

   3. Battery Selection

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 125-164

   4. Risk Assessment Using Test Results

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 165-173

   5. Applications of CPBS to Cancer Hazard Identification

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 175-202

4. Epilogue

   1. Epilogue

      • Julia Pet-Edwards, Yacov Y. Haimes, Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

      Pages 203-205

5. Back Matter

   Pages 207-211

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The difficulties associated with making risk assessments on the basis of experimental results are familiar to practitioners in many fields­ engineering, epidemiology, chemistry, etc. These difficulties are particularly common in problems that have dynamic and stochastic characteristics driven by multiple purposes and goals, with complex interconnections and inter­ dependencies. Acquiring an appropriate data base, processing and analyzing model results, and transmitting these results at an appropriate technical, social, political, and institutional level are additional difficulties that must be addressed. This book is grounded on the premise that risks are best assessed on the basis of experimental results and sound mathematical analyses, coupled with the knowledge of experts. The carcinogenicity prediction and battery selection (ePBS) approach described herein provides a systematic mechan­ ism-a synthesis of systems and statistical and decision analyses-to aid researchers and decision makers in the critical field of carcinogenicity prediction in selecting an appropriate battery of tests to use and in translating experimental results into information that can be used as an aid to decision making.

• battery
• chemistry
• decision making
• engine
• information
• interconnect
• model
• processing
• research
• risk
• risk assessment
• sound
• ecotoxicology

• University of Virginia, Charlottesville, USA

  Julia Pet-Edwards, Yacov Y. Haimes

• Case Western Reserve University, Cleveland, USA

  Vira Chankong, Herbert S. Rosenkranz, Fanny K. Ennever

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