Overview
- Editors:
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Steven Specter
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Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa, USA
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Mauro Bendinelli
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Department of Biomedicine, University of Pisa, Pisa, Italy
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Herman Friedman
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Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa, USA
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Table of contents (22 chapters)
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Front Matter
Pages i-xxii
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- Steven Specter, Herman Friedman, Mauro Bendinelli
Pages 1-18
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- Giuseppe Barbanti-Brodano
Pages 41-57
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- Warren A. Andiman, Marie F. Robert
Pages 59-72
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- David T. Purtilo, Helen L. Grierson
Pages 125-140
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- Lorne A. Babiuk, M. J. P. Lawman, P. Griebel
Pages 141-171
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- Carlo Garzelli, Takashi Onodera
Pages 193-200
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- Jagdev M. Sharma, J. M. Dupuy, L. Lamontagne
Pages 201-216
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- Carlo Garzelli, Fulvio Basolo, Donatella Matteucci, Bellur S. Prabhakar, Antonio Toniolo
Pages 217-234
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- Kathryn E. Wright, William E. Rawls
Pages 235-251
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- Man-Sun Sy, Robert Finberg
Pages 285-301
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- Norbert J. Roberts Jr., Frank Domurat
Pages 303-326
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- Raija Vainionpää, Timo Hyypiä
Pages 327-343
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- Paolo Casali, Minoru Nakamura, Michael B. McChesney
Pages 345-373
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- Robert W. Storms, Henry R. Bose Jr.
Pages 375-393
About this book
It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.
