The Pathobiology of Neoplasia

1. Front Matter

   Pages i-xxii

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2. Introduction Chronology of Significant Events in the Study of Neoplasia

   • Alphonse E. Sirica

   Pages 1-24

3. Classification of Neoplasms

   • Alphonse E. Sirica

   Pages 25-38

4. Chemical Carcinogenesis in Experimental Animals and Humans

   • Elizabeth K. Weisburger

   Pages 39-56

5. DNA Adducts and Carcinogenesis

   • Frederick A. Beland, Miriam C. Poirier

   Pages 57-80

6. Oncogenic Viruses

   • Mario R. Escobar

   Pages 81-109

7. Radiation Carcinogenesis

   • R. Timothy Mulcahy

   Pages 111-129

8. The Multistage Concept of Carcinogenesis

   • Carl Peraino, Carol A. Jones

   Pages 131-148

9. Organ and Species Specificity in Chemical Carcinogenesis and Tumor Promotion

   • Bhalchandra A. Diwan, Jerry M. Rice

   Pages 149-171

10. DNA Repair Mechanisms and Carcinogenesis

    • Steven L. Dresler

    Pages 173-197

11. Preneoplasia and Precancerous Lesions

    • Alphonse E. Sirica

    Pages 199-215

12. Tumor Progression and the Clonal Evolution of Neoplasia

    • Alphonse E. Sirica

    Pages 217-229

13. Cytogenetics and Human Neoplasia

    • Frederick Hecht, Barbara K. Hecht, Avery A. Sandberg

    Pages 231-246

14. Genetics of Susceptibility to Mouse Skin Tumor Promotion

    • John DiGiovanni

    Pages 247-274

15. Oncogenes

    • Eric H. Westin

    Pages 275-290

16. Activation of Oncogenes by Chemical Carcinogens

    • Marshall W. Anderson, Steven H. Reynolds

    Pages 291-304

17. Alterations in Biochemical Control Mechanisms of Neoplastic Cells

    • Charles E. Wenner, Anthony Cutry

    Pages 305-322

18. Membrane Alterations in Neoplasia

    • D. James Morré

    Pages 323-344

19. Growth Factors and Neoplasia

    • George K. Michalopoulos

    Pages 345-370

20. Biochemical Mechanisms of Action of the Phorbol Ester Class of Tumor Promoters

    • Arco Y. Jeng, Peter M. Blumberg

    Pages 371-383

This book is directed primarily to advanced graduate and medical students, postdoctoral trainees, and established investigators having basic research interests in neoplasia. Its content is based in part on the lecture outlines and selected histopathology laboratory components of an advanced course entitled The Pathobiology of Experimental Animal and Human Neoplasia, developed by me for the Experimental Pathology Curriculum of the Department of Pathology at the Medical College of Virginia. In this regard, an effort has been made to integrate pathology with carcinogenesis, genetics, biochemistry, and cellular and molecular biology in order to present a comprehensive and current view of the neoplastic process. For focus, emphasis is mainly being placed on the neoplastic cells themselves, and not on associated host-mediated responses. It ishoped that this book will accomplish its purpose of providing students and researchers who already possess strong but diverse basic science backgrounds with unifying concepts in tumor pathobiology, so as to stimulate new research aimed at furthering our understanding of neoplastic disease. I wish to express my appreciation and heartfelt thanks to the authors, whose individual ranges of expertise and research experience clearly bring to their respective chapters unique perspectives that easily transcend any redundancy that may be present. In addition, I am grateful to Drs. George Vennart, Saul Kay, and Fred Meier, and to Ms. Connie Wilkerson of the Department of Pathology at MCV, for their helpful comments and their review of some of the material.

• carcinogenesis
• genetics
• histopathology
• molecular biology
• pathology
• tumor

• Department of Pathology, Medical of College of Virginia, Virginia Commonwealth University, Richmond, USA

  Alphonse E. Sirica

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